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1دورية أكاديمية
المؤلفون: Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
المصدر: eLife, Vol 10 (2021)
مصطلحات موضوعية: mTOR, DEPTOR, cryo-EM, partial inhibition, cancer, signal transduction, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Maren Heimhalt (3349772), Pallavi Mukherjee (11681018), Ryan A. Grainger (10509637), Robert Szabla (7464806), Christopher Brown (258061), Rebecca Turner (1388115), Murray S. Junop (253521), Paul J. Berti (2056342)
مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Plant Biology, Virology, Chemical Sciences not elsewhere classified, providing new avenues, crystal structures showed, 2 kcal mol, 08 mg ml, 77 ± 0, 21 ± 0, typical good inhibitor, screen inhibitor fragments, tfp semicarbazone prevented, shikimate biosynthetic pathway, active site relative, 7 kcal mol, growth inhibition occurred, 50 sub, dahp synthase inhibition, shikimate pathway, active site, growth inhibition, synthase catalyzes
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المؤلفون: Robert Szabla, Paul J. Berti, Christopher M. Brown, Murray S. Junop, Pallavi Mukherjee, Maren Heimhalt, Rebecca Turner, Ryan A. Grainger
المصدر: ACS Infectious Diseases. 7:3292-3302
مصطلحات موضوعية: Stereochemistry, DAHP synthase, 010402 general chemistry, 01 natural sciences, Phosphates, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Escherichia coli, Aromatic amino acids, Shikimate pathway, 3-Deoxy-7-Phosphoheptulonate Synthase, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, ATP synthase, Chemistry, Active site, Oxime, 0104 chemical sciences, Kinetics, Infectious Diseases, Enzyme, biology.protein, Growth inhibition
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc14e474bc5a16e6b2ed5d3f9a528b8dTest
https://doi.org/10.1021/acsinfecdis.1c00462Test -
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المؤلفون: Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
مصطلحات موضوعية: Chemistry, Bipartite graph, DEPTOR, PI3K/AKT/mTOR pathway, Cell biology, Partial inhibition
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c63a7d4c77d781be24fc078b87ff7f22Test
https://doi.org/10.7554/elife.68799.sa2Test -
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المؤلفون: Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
المساهمون: Heimhalt, Maren [0000-0001-9993-2884], Anandapadamanaban, Madhanagopal [0000-0002-4237-0048], McLaughlin, Stephen [0000-0001-9135-6253], Williams, Roger L [0000-0001-7754-4207], Apollo - University of Cambridge Repository
المصدر: eLife, Vol 10 (2021)
eLifeمصطلحات موضوعية: Models, Molecular, Protein Conformation, Structural Biology and Molecular Biophysics, PDZ Domains, mTORC1, Image Processing, Computer-Assisted, structural biology, Biology (General), biology, Chemistry, General Neuroscience, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, General Medicine, Recombinant Proteins, Cell biology, mTOR, Medicine, Phosphorylation, Signal transduction, biological phenomena, cell phenomena, and immunity, signal transduction, Research Article, Protein Binding, RHEB, QH301-705.5, Science, PDZ domain, chemical biology, Mechanistic Target of Rapamycin Complex 1, DEPTOR, General Biochemistry, Genetics and Molecular Biology, partial inhibition, Biochemistry and Chemical Biology, molecular biophysics, Escherichia coli, biochemistry, Humans, cancer, human, PI3K/AKT/mTOR pathway, Binding Sites, General Immunology and Microbiology, Cell growth, Cryoelectron Microscopy, Gene Expression Regulation, biology.protein, cryo-EM, Function (biology)
وصف الملف: text/xml; application/pdf; application/zip
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36120c04dfaa3fc5886b70680a712cTest
https://doi.org/10.1101/2021.04.28.441853Test -
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المؤلفون: Paul J. Berti, Shan Jiang, Maren Heimhalt
المصدر: Biochemistry. 57(48)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, Mutant, DAHP synthase, Biochemistry, Binding, Competitive, Metal, 03 medical and health sciences, chemistry.chemical_compound, Deprotonation, Catalytic Domain, Oximes, Side chain, Escherichia coli, 3-Deoxy-7-Phosphoheptulonate Synthase, Enzyme Inhibitors, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, Escherichia coli Proteins, Active site, Sugar Acids, Hydrogen-Ion Concentration, Oxime, Kinetics, 030104 developmental biology, Amino Acid Substitution, Metals, visual_art, visual_art.visual_art_medium, biology.protein, Mutagenesis, Site-Directed, Intracellular
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc18261603669e43233ff7a4ce96838Test
https://pubmed.ncbi.nlm.nih.gov/30398055Test -
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المؤلفون: Maren Heimhalt, Paul J. Berti, Murray S. Junop, Derek J. Wilson, Frederick To, Naresh Balachandran, Peter Liuni
المصدر: Biochemistry. 55(48)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, Dimer, DAHP synthase, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Protein Domains, Tetrahedral carbonyl addition compound, Oximes, Escherichia coli, Shikimate pathway, 3-Deoxy-7-Phosphoheptulonate Synthase, 030102 biochemistry & molecular biology, biology, ATP synthase, Molecular Structure, Escherichia coli Proteins, Deuterium Exchange Measurement, Sugar Acids, Oxime, Kinetics, 030104 developmental biology, chemistry, Erythrose, biology.protein, Biocatalysis, Protein Multimerization, Phosphoenolpyruvate carboxykinase, Algorithms, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d9d615b3844d9674bf4505bbd0540Test
https://pubmed.ncbi.nlm.nih.gov/27933795Test -
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المؤلفون: Maren Heimhalt
المساهمون: Berti, Paul J., Chemistry
المصدر: Maren Heimhalt
مصطلحات موضوعية: enzyme inhibitors, imine-based molecules, DAHPS, antibiotics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::621a6129042c94e484ac75d9bba8665dTest
http://hdl.handle.net/11375/22889Test