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1دورية أكاديمية
المؤلفون: Bindu Murthy, Qihong Zhao, Takafumi Ide, Manoj Chiney, Huynh Yen Thanh Bach, Vineet Goti, Coburn Hobar, Urvi Aras
المصدر: Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2053-8790Test
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المؤلفون: Mohamad Shebley, John P. Gibbs, Manoj Chiney, Sumit Bhatnagar, Jared Weddell
المصدر: Clinical and Translational Science, Vol 14, Iss 1, Pp 395-404 (2021)
Clinical and Translational Scienceمصطلحات موضوعية: Drug, Oncology, medicine.medical_specialty, Immunoconjugates, media_common.quotation_subject, Population, Antineoplastic Agents, Breast Neoplasms, Ado-Trastuzumab Emtansine, Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, Pharmacokinetics, Internal medicine, medicine, Humans, Potency, Tissue Distribution, Breast, General Pharmacology, Toxicology and Pharmaceutics, education, Cytotoxicity, media_common, education.field_of_study, biology, business.industry, Research, General Neuroscience, lcsh:Public aspects of medicine, lcsh:RM1-950, Dose fractionation, lcsh:RA1-1270, Articles, General Medicine, medicine.disease, Metastatic breast cancer, Tumor Burden, body regions, lcsh:Therapeutics. Pharmacology, Area Under Curve, biology.protein, Female, Antibody, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6284a8063769d0eae78addf5c7cd38bcTest
https://doaj.org/article/312cea22690440858ae4609ed1a38617Test -
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المؤلفون: Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine
المصدر: Journal of Medicinal Chemistry. 64:677-694
مصطلحات موضوعية: Cyclopropanes, TYK2 Kinase, Chemistry, Hydrogen bond, Drug discovery, Ligand, Stereochemistry, Plasma protein binding, Crystallography, X-Ray, Catalysis, Pyridazine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, Animals, Humans, Psoriasis, Molecular Medicine, Structure–activity relationship, Moiety, Oxazoles, Protein Kinase Inhibitors, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717944d40cbaa5837d6bde470301607Test
https://doi.org/10.1021/acs.jmedchem.0c01698Test -
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المؤلفون: Manoj Chiney, Mohamad Shebley, Juki Ng, John P. Gibbs
المصدر: Clinical Pharmacokinetics
مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Hydrocarbons, Fluorinated, Digoxin, media_common.quotation_subject, Endometriosis, Cmax, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacology (medical), Original Research Article, media_common, CYP3A4, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Disposition, Organic anion-transporting polypeptide, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Female, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbca4e35c3d4d7994bdc6b70035aa75Test
https://doi.org/10.1007/s40262-019-00833-6Test -
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المؤلفون: Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
المصدر: Journal of Medicinal Chemistry. 62:8953-8972
مصطلحات موضوعية: Nicotinamide, medicine.drug_class, Allosteric regulation, Carboxamide, Pyridazine, chemistry.chemical_compound, chemistry, Biochemistry, Tyrosine kinase 2, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Transferase, Tyrosine kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7ce72d9f5c30b5b21e9d4c5dd0ac4218Test
https://doi.org/10.1021/acs.jmedchem.9b00443Test -
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المؤلفون: Orlando F. Bueno, Bo Tong, Ahmed Salem, Manoj Chiney, Rajeev M. Menon
المصدر: Xenobiotica. 48:904-910
مصطلحات موضوعية: Adult, Digoxin, Health, Toxicology and Mutagenesis, Cmax, Antineoplastic Agents, Urine, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Therapeutic index, Pharmacokinetics, Humans, Medicine, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Sulfonamides, Cross-Over Studies, Venetoclax, business.industry, General Medicine, Middle Aged, Drug interaction, Bridged Bicyclo Compounds, Heterocyclic, Crossover study, chemistry, 030220 oncology & carcinogenesis, Female, business, Half-Life, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292490be75092050a66eae12e8688823Test
https://doi.org/10.1080/00498254.2017.1381779Test -
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المؤلفون: Y.-W. Chang, Victor Moreno, Mark J. Ratain, Emiliano Calvo, Patricia LoRusso, Monica Motwani, Sudhir Penugonda, M.J.A. de Jonge, Drew W. Rasco, Adam M. Petrich, Manoj Chiney
المصدر: Annals of Oncology. 30:v169-v170
مصطلحات موضوعية: medicine.medical_specialty, business.industry, Tumor cells, Hematology, First in human, Pleuritic pain, Oncology, Dose optimization, Family medicine, Partial response, Maximum tolerated dose, medicine, In patient, Previously treated, business, health care economics and organizations
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e9d114ecf0642a2a69cdb98cc1db950cTest
https://doi.org/10.1093/annonc/mdz244.019Test -
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المؤلفون: Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
المصدر: Journal of medicinal chemistry. 62(20)
مصطلحات موضوعية: Gene isoform, Allosteric regulation, Crystallography, X-Ray, 01 natural sciences, Autoimmune Diseases, 03 medical and health sciences, Mice, Allosteric Regulation, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Humans, Kinome, Protein Kinase Inhibitors, 030304 developmental biology, Autoimmune disease, TYK2 Kinase, 0303 health sciences, Kinase Family, Chemistry, medicine.disease, Highly selective, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Tyrosine kinase 2, Cancer research, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a281427643b3f6489276fb5c4ffe37Test
https://pubmed.ncbi.nlm.nih.gov/31603320Test -
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المؤلفون: Ryan, Moslin, Yanlei, Zhang, Stephen T, Wrobleski, Shuqun, Lin, Michael, Mertzman, Steven, Spergel, John S, Tokarski, Joann, Strnad, Kathleen, Gillooly, Kim W, McIntyre, Adriana, Zupa-Fernandez, Lihong, Cheng, Huadong, Sun, Charu, Chaudhry, Christine, Huang, Celia, D'Arienzo, Elizabeth, Heimrich, Xiaoxia, Yang, Jodi K, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dawn, Mulligan, Dianlin, Xie, Nelly, Aranibar, Manoj, Chiney, James R, Burke, Louis, Lombardo, Percy H, Carter, David S, Weinstein
المصدر: Journal of medicinal chemistry. 62(20)
مصطلحات موضوعية: Niacinamide, TYK2 Kinase, Mice, Structure-Activity Relationship, Allosteric Regulation, Nicotinic Acids, Animals, Humans, Ligands, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a6a5ff3f143a4460f1c63e1a663ab705Test
https://pubmed.ncbi.nlm.nih.gov/31314518Test -
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المؤلفون: Mark J. Ratain, Emiliano Calvo, Martin Dunbar, Drew W. Rasco, Maja J.A. de Jonge, Adam M. Petrich, Patricia LoRusso, Manoj Chiney, Toshihiko Doi, Jaimee Glasgow, Monica Motwani
المصدر: Journal of Clinical Oncology. 37:3013-3013
مصطلحات موضوعية: Agonist, Cancer Research, medicine.drug_class, business.industry, First in human, Ligand (biochemistry), Fusion protein, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Phase (matter), Apoptotic cell death, medicine, Receptor, business, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c46b2b36eeb62b8d33bd1d9932351f97Test
https://doi.org/10.1200/jco.2019.37.15_suppl.3013Test