دورية أكاديمية
No evidence for systemic low‐grade inflammation in adult patients with early‐treated phenylketonuria: The INGRAPH study
| العنوان: | No evidence for systemic low‐grade inflammation in adult patients with early‐treated phenylketonuria: The INGRAPH study |
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| المؤلفون: | Chloé Giret, Yann Dos Santos, Hélène Blasco, Christophe Paget, Loïc Gonzalez, Nathalie Tressel, Maeva Dieu, Adrien Bigot, Valérie Gissot, Alexandra Audemard‐Verger, François Maillot |
| المصدر: | JIMD Reports, Vol 64, Iss 6, Pp 446-452 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Genetics |
| مصطلحات موضوعية: | cardiovascular risk, C‐reactive‐protein, cytokines, inflammation, phenylketonuria, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470 |
| الوصف: | Abstract The question of an increased cardiovascular risk has been recently raised in adults with phenylketonuria (PKU). As low‐grade systemic inflammation increases cardiovascular risk, the INGRAPH study aimed to evaluate low‐grade inflammation in adult PKU patients compared to healthy controls and to determine the potential influence of Phe‐controlled diet on inflammation. Twenty early‐treated adult PKU patients, including a subgroup of 15 classical PKU patients, and 20 healthy volunteers were included. PKU patients and healthy subjects were matched on age, sex and body mass index class. Plasma concentrations of CRP, IFNg, IL1a, IL1b, IL2, IL6, IL10, and TNFα were measured in PKU patients and compared to controls. Plasma CRP was not different in the PKU group as compared to controls. No significant differences were observed between the two groups concerning plasma cytokines concentrations. Plasma CRP and cytokine profile were not different between “on diet” and “off diet” PKU patients. All these results were similar considering only the classical PKU subgroup. No differences were shown in plasma CRP and pro‐inflammatory cytokines between adult PKU patients and healthy controls. Further studies are needed, including more patients and extensive characterization of systemic low‐grade inflammation, as cardiovascular risk appears to be a new concern in adult PKU population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-8312 |
| العلاقة: | https://doaj.org/toc/2192-8312Test |
| DOI: | 10.1002/jmd2.12366 |
| الوصول الحر: | https://doaj.org/article/6254caf3ae1743d8b9715c8c5e206521Test |
| رقم الانضمام: | edsdoj.6254caf3ae1743d8b9715c8c5e206521 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21928312 |
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| DOI: | 10.1002/jmd2.12366 |