نتائج البحث - "Macgowan, Stuart"

1

دورية أكاديمية

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

وصف الملف: text

العلاقة: https://researchonline.lshtm.ac.uk/id/eprint/4671107/1/Cleghorn-etal-2023-Development-of-a-2-4-Diaminothiazole-Series.pdfTest; Cleghorn, Laura AT; Wall, Richard J ; Albrecht, Sébastien; MacGowan, Stuart A; Norval, Suzanne; De Rycker, Manu; Woodland, Andrew; Spinks, Daniel; Thompson, Stephen; Patterson, Stephen; +12 more. Corpas Lopez, Victoriano; Dey, Gourav; Collie, Iain T; Hallyburton, Irene; Kime, Robert; Simeons, Frederick RC; Stojanovski, Laste; Frearson, Julie A; Wyatt, Paul G; Read, Kevin D; Gilbert, Ian H; Wyllie, Susan; (2023) Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues. Journal of medicinal chemistry, 66 (13). pp. 8896-8916. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.3c00509Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00509Test
https://researchonline.lshtm.ac.uk/id/eprint/4671107Test/
https://researchonline.lshtm.ac.uk/id/eprint/4671107/1/Cleghorn-etal-2023-Development-of-a-2-4-Diaminothiazole-Series.pdfTest

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2

دورية أكاديمية

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies

المؤلفون: Portnoi, Marie-France, Dumargne, Marie-Charlotte, Rojo, Sandra, Witchel, Selma F, Duncan, Andrew J, Eozenou, Caroline, Bignon-Topalovic, Joelle, Yatsenko, Svetlana A, Rajkovic, Aleksandar, Reyes-Mugica, Miguel, Almstrup, Kristian, Fusee, Leila, Srivastava, Yogesh, Chantot-Bastaraud, Sandra, Hyon, Capucine, Louis-Sylvestre, Christine, Validire, Pierre, de Malleray Pichard, Caroline, Ravel, Celia, Christin-Maitre, Sophie, Brauner, Raja, Rossetti, Raffaella, Persani, Luca, Charreau, Eduardo H, Dain, Liliana, Chiauzzi, Violeta A, Mazen, Inas, Rouba, Hassan, Schluth-Bolard, Caroline, MacGowan, Stuart, McLean, WH Irwin, Patin, Etienne, Meyts, Ewa Rajpert-De, Jauch, Ralf, Achermann, John C, Siffroi, Jean-Pierre, McElreavey, Ken, Bashamboo, Anu

المصدر: Human Molecular Genetics. 27(7)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/41s0n02dTest

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3

تقرير

A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites

المؤلفون: MacGowan, Stuart A., Madeira, Fábio, Britto-Borges, Thiago, Barton, Geoffrey J.

المصدر: MacGowan , S A , Madeira , F , Britto-Borges , T & Barton , G J 2023 ' A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites ' Research Square . https://doi.org/10.21203/rs.3.rs-3160340/v1Test

العلاقة: https://discovery.dundee.ac.uk/en/publications/30e56541-7bb0-408d-8c2e-e9d01ea9ec89Test

الإتاحة: https://doi.org/10.21203/rs.3.rs-3160340/v1Test
https://discovery.dundee.ac.uk/en/publications/30e56541-7bb0-408d-8c2e-e9d01ea9ec89Test

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4

تقرير

Classification of likely functional state for ligand binding sites identified from fragment screening

المؤلفون: Utgés, Javier S., MacGowan, Stuart A., Ives, Callum M., Barton, Geoffrey J.

المصدر: Utgés , J S , MacGowan , S A , Ives , C M & Barton , G J 2023 ' Classification of likely functional state for ligand binding sites identified from fragment screening ' Research Square . https://doi.org/10.21203/rs.3.rs-3185838/v1Test

العلاقة: https://discovery.dundee.ac.uk/en/publications/a8913db2-de0d-4b69-8e5f-bf6729facd90Test

الإتاحة: https://doi.org/10.21203/rs.3.rs-3185838/v1Test
https://discovery.dundee.ac.uk/en/publications/a8913db2-de0d-4b69-8e5f-bf6729facd90Test

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5

دورية أكاديمية

Classification of likely functional class for ligand binding sites identified from fragment screening.

المؤلفون: Utgés, Javier S.¹ (AUTHOR), MacGowan, Stuart A.¹ (AUTHOR), Ives, Callum M.^1,2 (AUTHOR), Barton, Geoffrey J.¹ (AUTHOR) gjbarton@dundee.ac.uk

المصدر: Communications Biology. 3/13/2024, Vol. 7 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *LIGAND binding (Biochemistry), *BINDING sites, *MACHINE learning, *PROTEIN-ligand interactions, *DRUG discovery

النص الكامل

6

دورية أكاديمية

A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites.

المؤلفون: MacGowan, Stuart A.¹ (AUTHOR), Madeira, Fábio^1,2 (AUTHOR), Britto-Borges, Thiago^1,3 (AUTHOR), Barton, Geoffrey J.¹ (AUTHOR) gjbarton@dundee.ac.uk

المصدر: Communications Biology. 2/17/2024, Vol. 7 Issue 1, p1-10. 10p.

النص الكامل

7

دورية أكاديمية

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

المؤلفون: MacGowan, Stuart A., Barton, Michael I., Kutuzov, Mikhail, Dushek, Omer, van der Merwe, P. Anton, Barton, Geoffrey J.

المساهمون: Deane, Charlotte M., Biotechnology and Biological Sciences Research Council, Wellcome Trust

المصدر: PLOS Computational Biology ; volume 18, issue 3, page e1009922 ; ISSN 1553-7358

الإتاحة: https://doi.org/10.1371/journal.pcbi.1009922Test

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8

دورية أكاديمية

Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

المصدر: Journal of Allergy and Clinical Immunology. 136(5)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5sn426w3Test

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9

دورية أكاديمية

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

المؤلفون: Barton, Michael I, MacGowan, Stuart A, Kutuzov, Mikhail A, Dushek, Omer, Barton, Geoffrey John, van der Merwe, P Anton

المساهمون: Wellcome Trust, Biotechnology and Biological Sciences Research Council

المصدر: eLife ; volume 10 ; ISSN 2050-084X

الإتاحة: https://doi.org/10.7554/elife.70658Test
https://cdn.elifesciences.org/articles/70658/elife-70658-v3.pdfTest
https://cdn.elifesciences.org/articles/70658/elife-70658-v3.xmlTest
https://elifesciences.org/articles/70658Test

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10

دورية أكاديمية

Ankyrin repeats in context with human population variation

المؤلفون: Utgés, Javier S., Tsenkov, Maxim I., Dietrich, Noah J. M., MacGowan, Stuart A., Barton, Geoffrey J.

المساهمون: Dunbrack, Roland L., Biotechnology and Biological Sciences Research Council, BBSRC EASTBIO Ph.D. Studentship, Wellcome Trust Ph.D. studentship, Wellcome Trust

المصدر: PLOS Computational Biology ; volume 17, issue 8, page e1009335 ; ISSN 1553-7358

الإتاحة: https://doi.org/10.1371/journal.pcbi.1009335Test

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