المؤلفون: Knight, John R.P., Alexandrou, Constantinos, Skalka, George L., Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M., May-Wilson, Sebastian, Smith, Ewan M., Najumudeen, Arafath K., Gilroy, Kathryn, Ridgway, Rachel A., Flanagan, Dustin J., Smith, Rachael C.L., McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D., Jackstadt, Rene, Waldron, Joseph A., Campbell, Andrew D., Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M., Sonenberg, Nahum, Proud, Christopher G., Jones, Neil P., Swarbrick, Martin E., McKinnon, Heather J., Faller, William J., Quesne, John Le, Edwards, Joanne, Willis, Anne E., Bushell, Martin, Sansom, Owen J.

المصدر: Knight , J R P , Alexandrou , C , Skalka , G L , Vlahov , N , Pennel , K , Officer , L , Teodosio , A , Kanellos , G , Gay , D M , May-Wilson , S , Smith , E M , Najumudeen , A K , Gilroy , K , Ridgway , R A , Flanagan , D J , Smith , R C L , McDonald , L , MacKay , C , Cheasty , A , McArthur , K , Stanway , E , Leach , J D , ....

مصطلحات موضوعية: Animals, Colorectal Neoplasms/genetics, Disease Models, Animal, Eukaryotic Initiation Factor-4E/drug effects, Humans, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mice, Inbred C57BL, Phosphorylation, Protein Serine-Threonine Kinases/drug effects, ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre

العلاقة: https://research.manchester.ac.uk/en/publications/e2b9afde-dfcb-40fe-b3a3-ece044a73148Test

الإتاحة: https://doi.org/10.1158/2159-8290.CD-20-0652Test
https://research.manchester.ac.uk/en/publications/e2b9afde-dfcb-40fe-b3a3-ece044a73148Test

المؤلفون: Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell

المصدر: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652Test

مصطلحات موضوعية: 0301 basic medicine, Eukaryotic Initiation Factor-4E/drug effects, Colorectal cancer, Mutant, mTORC1, Biology, medicine.disease_cause, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Protein Serine-Threonine Kinases/drug effects, Phosphorylation, neoplasms, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mutation, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, EIF4E, Translation (biology), medicine.disease, Colorectal Neoplasms/genetics, digestive system diseases, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, KRAS

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3Test
https://doi.org/10.1158/2159-8290.CD-20-0652Test

المؤلفون: Shao-Pei Hung, Wen-Chin Lee, Hsiang-Hao Hsu, Jin-Bor Chen, You-Ying Chau, Terry Ting-Yu Chiou

المصدر: Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112349-(2021)
Chioua, T T-Y, Chau, Y-Y, Chen, J-B, Hsu, H-H, Huang, S-P & Lee, W-C 2021, ' Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway ', Biomedicine and Pharmacotherapy, vol. 144 . https://doi.org/10.1016/j.biopha.2021.112349Test

مصطلحات موضوعية: Membranous nephropathy, Apoptosis Regulatory Proteins/metabolism, Phospholipase A2 receptor, Podocyte, Apoptosis, RM1-950, Glomerulonephritis, Membranous, Cell Line, chemistry.chemical_compound, Downregulation and upregulation, Proto-Oncogene Proteins c-akt/metabolism, medicine, Humans, LY294002, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, MTOR Inhibitors/pharmacology, Pharmacology, TOR Serine-Threonine Kinases/antagonists & inhibitors, Mammalian target of rapamycin, biology, Podocytes, Chemistry, Receptors, Phospholipase A2, TOR Serine-Threonine Kinases, Cytochrome c, Apoptosis/drug effects, Sirolimus/pharmacology, MTOR Inhibitors, General Medicine, Enzyme Activation, Crosstalk (biology), Receptors, Phospholipase A2/metabolism, medicine.anatomical_structure, Cancer research, biology.protein, Therapeutics. Pharmacology, Phosphatidylinositol 3-Kinase, Podocytes/drug effects, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Phosphatidylinositol 3-Kinase/metabolism, Glomerulonephritis, Membranous/drug therapy, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d35f5abc372da2d816d2bcd3713e5Test
https://doi.org/10.1016/j.biopha.2021.112349Test