التفاصيل البيبلوغرافية
العنوان:
Gender-Dependent Differences in Plasma Matrix Metalloproteinase-8 Elevated in Pulmonary Tuberculosis
المؤلفون:
Christopher H. Woelk , Borislav D. Dimitrov , Paul T. Elkington , Tarangini Sathyamoorthy , Liku B. Tezera , Gurjinder Sandhu , Jon S. Friedland , Richard Thomas , Carlton A. Evans , Akul Singhania , Dan Agranoff
المساهمون:
Medical Research Council (MRC)
المصدر:
PLoS ONE, Vol 10, Iss 1, p e0117605 (2015)
بيانات النشر:
Public Library of Science, 2014.
سنة النشر:
2014
مصطلحات موضوعية:
TISSUE INHIBITORS , Male , principal component analysis , Neutrophils , correlation analysis , LEVEL , lcsh:Medicine , PROTEIN , DISEASE , Body Mass Index , Pathogenesis , Immunopathology , middle aged , lcsh:Science , GENE-EXPRESSION , Principal Component Analysis , Sex Characteristics , Multidisciplinary , biology , matrilysin , neutrophil , lung tuberculosis , Middle Aged , cohort analysis , Up-Regulation , Multidisciplinary Sciences , female , multivariate analysis , Matrix Metalloproteinase 8 , Science & Technology - Other Topics , disease severity , Female , medicine.symptom , Matrix Metalloproteinase 1 , interstitial collagenase , prospective study , Research Article , Adult , Tuberculosis , purl.org/pe-repo/ocde/ford#5.04.02 [https] , TRANSMISSION , General Science & Technology , sex difference , enzymology , MMP1 protein, human , Article , gelatinase B , enzyme blood level , Mycobacterium tuberculosis , neutrophil collagenase , Young Adult , sexual development , blood , MD Multidisciplinary , medicine , Humans , controlled study , human , Matrilysin , Tuberculosis, Pulmonary , Science & Technology , business.industry , lcsh:R , MATRIX-METALLOPROTEINASE-9 , Case-control study , COMMUNITY-ACQUIRED PNEUMONIA , case control study , medicine.disease , biology.organism_classification , major clinical study , body mass , SEVERITY , purl.org/pe-repo/ocde/ford#3.02.07 [https] , Case-Control Studies , Immunology , CELLS , Multivariate Analysis , Sputum , lcsh:Q , business , Body mass index , upregulation
الوصف:
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p
وصف الملف:
application/pdf; application/octet-stream
اللغة:
English
تدمد:
1932-6203
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda16d99cc2a8f254f8605a6b48367cdTest http://hdl.handle.net/10044/1/30566Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....dda16d99cc2a8f254f8605a6b48367cd
قاعدة البيانات:
OpenAIRE
