T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients
| العنوان: | T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients |
|---|---|
| المؤلفون: | A. Del Bello, Nassim Kamar, E Treiner |
| المساهمون: | Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Néphrologie et Transplantation d'organes, Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], CHU Toulouse [Toulouse] |
| المصدر: | Clinical and Experimental Immunology Clinical and Experimental Immunology, Wiley, 2020, 200 (1), pp.89-104. ⟨10.1111/cei.13412⟩ Clin Exp Immunol |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, T-Lymphocytes, MESH: ABO Blood-Group System / immunology, medicine.medical_treatment, Receptor expression, Programmed Cell Death 1 Receptor, MESH: HLA Antigens / genetics, MESH: Blood Group Incompatibility / immunology, MESH: Histocompatibility / immunology, MESH: Programmed Cell Death 1 Receptor / genetics, donor-specific antibodies, MESH: Lymphocyte Depletion / methods, 0302 clinical medicine, HLA Antigens, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Living Donors, Immunology and Allergy, Receptors, Immunologic, immune exhaustion, MESH: T-Lymphocytes / immunology, MESH: Living Donors, MESH: Aged, MESH: Middle Aged, MESH: HLA Antigens / metabolism, MESH: Receptors, Immunologic / immunology, Graft Survival, Middle Aged, MESH: Graft Survival / immunology, MESH: ABO Blood-Group System / genetics, Cytokine, medicine.anatomical_structure, Blood Group Incompatibility, Histocompatibility, Female, graft rejection, MESH: Signaling Lymphocytic Activation Molecule Family / immunology, MESH: Histocompatibility / genetics, MESH: T-Lymphocytes / metabolism, Adult, T cell, Immunology, T cells, MESH: Graft Survival / genetics, MESH: Programmed Cell Death 1 Receptor / immunology, MESH: Receptors, Immunologic / metabolism, Human leukocyte antigen, Biology, Lymphocyte Depletion, MESH: Kidney Transplantation / methods, ABO Blood-Group System, MESH: Programmed Cell Death 1 Receptor / metabolism, 03 medical and health sciences, MESH: Cross-Sectional Studies, Immune system, TIGIT, Signaling Lymphocytic Activation Molecule Family, medicine, Humans, ABO-incompatible transplantation, Aged, MESH: Receptors, Immunologic / genetics, MESH: Gene Expression Profiling / methods, MESH: Humans, MESH: Blood Group Incompatibility / genetics, Gene Expression Profiling, MESH: Signaling Lymphocytic Activation Molecule Family / metabolism, MESH: Adult, Original Articles, Kidney Transplantation, cytokines, MESH: Male, Transplantation, Cross-Sectional Studies, inhibitory receptors, 030104 developmental biology, MESH: HLA Antigens / immunology, MESH: Signaling Lymphocytic Activation Molecule Family / genetics, MESH: Female, transplantation, 030215 immunology |
| الوصف: | Summary Chronic antigen stimulation can lead to immune exhaustion (a state of T cell dysfunction). Several phenotypical signatures of T cell exhaustion have been described in various pathological situations, characterized by aberrant expression of multiple inhibitory receptors (IR). This signature has been barely studied in the context of allogenic organ transplantation. We undertook a cross-sectional analysis of the expression of IR [CD244, CD279, T cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibition motif (ITIM) domains (TIGIT) and CD57] and their correlation with cytokine-producing functions in T cells reconstituting after lymphocyte depletion in patients transplanted from living donors, with preformed donor-specific antibodies. After ABO incompatible transplantation, T cells progressively acquired a phenotype similar to healthy donors and the expression of several IR marked cells with increased functions, with the exception of TIGIT, which was associated with decreased cytokine production. In stark contrast, T cell reconstitution in patients with anti-human leukocyte antigen (HLA) antibodies was characterized with an increased co-expression of IR by T cells, and specifically by an increased expression of TIGIT. Furthermore, expression of these receptors was no longer directly correlated to cytokine production. These results suggest that T cell alloreactivity in HLA-incompatible kidney transplantation drives an aberrant T cell reconstitution with respect to IR profile, which could have an impact on the transplantation outcome. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224fd1281567a921d5b700e491fdcbe5Test https://doi.org/10.1111/cei.13412Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....224fd1281567a921d5b700e491fdcbe5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
|---|