Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy
| العنوان: | Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy |
|---|---|
| المؤلفون: | Rosa Barreira da Silva, Melissa E Laird, Nader Yatim, Laurence Fiette, Molly A Ingersoll, Matthew L Albert |
| المساهمون: | Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Histopathologie humaine et Modèles animaux, Institut Pasteur [Paris] (IP), Funding was provided by the Institut Pasteur (Pasteur-Roux post-doctoral fellowship to R.B.d.S.), the Pasteur Foundation (fellowship to M.E.L.), the Ligue Contre le Cancer (M.L.A.), the Fondation ARC pour la recherche sur le cancer (M.L.A.) and the French government's Invest in the Future Program, managed by the Agence Nationale de la Recherche (LabEx Immuno-Onco (R.B.d.S., M.E.L., N.Y., M.A.I. and M.L.A.))., ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] |
| المصدر: | Nature Immunology Nature Immunology, 2015, 16 (8), pp.850-858. ⟨10.1038/ni.3201⟩ Nature Immunology, Nature Publishing Group, 2015, 16 (8), pp.850-858. ⟨10.1038/ni.3201⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Adoptive cell transfer, Lymphocyte, medicine.medical_treatment, Cancer immunotherapy, MESH: Flow Cytometry, CXCR3, MESH: Mice, Knockout, MESH: Cell Movement/drug effects, 0302 clinical medicine, Cell Movement, MESH: Triazoles/pharmacology, Immunology and Allergy, MESH: Animals, MESH: Chemokines/metabolism, Lymphocytes, Mice, Knockout, Mice, Inbred BALB C, 0303 health sciences, Chemistry, Flow Cytometry, Adoptive Transfer, 3. Good health, MESH: Dipeptidyl Peptidase 4/immunology, medicine.anatomical_structure, MESH: Neoplasms, Experimental/genetics, MESH: Dipeptidyl Peptidase 4/genetics, MESH: Pyrazines/pharmacology, Pyrazines, 030220 oncology & carcinogenesis, MESH: Neoplasms, Experimental/immunology, MESH: Chemokine CXCL10/metabolism, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Immunotherapy, Chemokines, MESH: Chemokine CXCL10/immunology, Receptors, CXCR3, MESH: Cell Line, Tumor, MESH: Mice, Transgenic, Dipeptidyl Peptidase 4, T cell, Immunology, MESH: Mice, Inbred BALB C, MESH: Immunotherapy/methods, MESH: Cell Movement/immunology, Mice, Transgenic, MESH: Receptors, CXCR3/immunology, 03 medical and health sciences, Immune system, MESH: Mice, Inbred C57BL, Cell Line, Tumor, MESH: Lymphocytes/metabolism, medicine, Animals, CXCL10, MESH: Sitagliptin Phosphate, 030304 developmental biology, MESH: Neoplasms, Experimental/therapy, Dipeptidyl-Peptidase IV Inhibitors, Protein transport, MESH: Dipeptidyl-Peptidase IV Inhibitors/pharmacology, Sitagliptin Phosphate, Neoplasms, Experimental, Triazoles, MESH: Male, Chemokine CXCL10, Mice, Inbred C57BL, MESH: Adoptive Transfer, MESH: Receptors, CXCR3/metabolism, MESH: Dipeptidyl Peptidase 4/metabolism, MESH: Lymphocytes/immunology, MESH: Female, MESH: Chemokines/immunology |
| الوصف: | International audience; The success of antitumor immune responses depends on the infiltration of solid tumors by effector T cells, a process guided by chemokines. Here we show that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10 and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide direct in vivo evidence for control of lymphocyte trafficking via CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing biologically active forms of chemokines as a strategy to enhance tumor immunotherapy. |
| اللغة: | English |
| تدمد: | 1529-2908 1529-2916 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e2ab8828a29afd88e17c54fdc280cdTest https://hal-pasteur.archives-ouvertes.fr/pasteur-01380810Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....49e2ab8828a29afd88e17c54fdc280cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292908 15292916 |
|---|