المؤلفون: Blanquart, Samuel, Varré, Jean-Stéphane, Guertin, Paul, Perrin, Amandine, Bergeron, Anne, Swenson, Krister, M.

المساهمون: Bioinformatics and Sequence Analysis (BONSAI), Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire de combinatoire et d'informatique mathématique Montréal (LaCIM), Centre de Recherches Mathématiques Montréal (CRM), Université de Montréal (UdeM)-Université de Montréal (UdeM)-Université du Québec à Montréal = University of Québec in Montréal (UQAM), Collège André-Grasset Montréal, Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Computationnelle (IBC), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AB is partially supported by Canada NSERC Grant number 05729-2014, and by Équipes associées Inria-FRQNT Grant number 188128. This research is supported by the Inria Associate Team program.Inria associated team CG-ALCODE (2014-2016)

المصدر: ISSN: 1471-2164 ; BMC Genomics ; https://inria.hal.science/hal-01396410Test ; BMC Genomics, 2016, Proceedings of the 14th Annual Research in Computational Molecular Biology (RECOMB) Comparative Genomics Satellite Workshop: genomics, 17 (Suppl 10), pp.786. ⟨10.1186/s12864-016-3103-6⟩.

مصطلحات موضوعية: Splicing orthologs, Transcriptome prediction, Eukaryotes, MESH: Algorithms, MESH: Alternative Splicing, MESH: Proteins / chemistry, MESH: Proteins / genetics, MESH: Proteins / metabolism, MESH: RNA / chemistry, MESH: RNA / genetics, MESH: RNA / metabolism, MESH: Transcriptome, MESH: Animals, MESH: Computational Biology, MESH: Exons, MESH: Humans, MESH: Mice, MESH: Protein Isoforms / chemistry, MESH: Protein Isoforms / genetics, MESH: Protein Isoforms / metabolism, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28185551; hal-01396410; https://inria.hal.science/hal-01396410Test; https://inria.hal.science/hal-01396410/documentTest; https://inria.hal.science/hal-01396410/file/2016-10%20blanquart%20etal%20BMCgenomics.pdfTest; PUBMED: 28185551; PUBMEDCENTRAL: PMC5123294

الإتاحة: https://doi.org/10.1186/s12864-016-3103-6Test
https://inria.hal.science/hal-01396410Test
https://inria.hal.science/hal-01396410/documentTest
https://inria.hal.science/hal-01396410/file/2016-10%20blanquart%20etal%20BMCgenomics.pdfTest

المؤلفون: Miras, Isabelle, Saul, Frederick, Nowakowski, Mireille, Weber, Patrick, Haouz, Ahmed, Shepard, William, Picardeau, Mathieu

المساهمون: Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Production de Protéines Recombinantes (Plate-Forme) (PRPF), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Biologie des Spirochètes / Biology of Spirochetes, Institut Pasteur Paris (IP), This work was supported by the Institut Pasteur and the French Ministry of Research (ANR-08-MIE-018)., We acknowledge access to the PROXIMA1 beamline at SOLEIL and the support from its staff. We thank Jacques Bellalou for assistance in protein-production optimization and Vincent Bondet for protein purification at an early stage of the work (PFPR, Institut Pasteur), ANR-08-MIEN-0018,LEPTOVIR,Les leptospires : de la génétique à la pathogénèse(2008)

المصدر: ISSN: 2059-7983 ; EISSN: 2059-7983.

مصطلحات موضوعية: spirochaetes, Leptospira, LRR motif, crystal structure, MESH: Amino Acid Sequence, MESH: Bacterial Proteins, MESH: Cloning, Molecular, MESH: Crystallography, X-Ray, MESH: Leptospira interrogans/chemistry, MESH: Proteins/genetics, MESH: Molecular Sequence Data, MESH: Protein Conformation, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26057675; pasteur-02539010; https://pasteur.hal.science/pasteur-02539010Test; https://pasteur.hal.science/pasteur-02539010/documentTest; https://pasteur.hal.science/pasteur-02539010/file/ELECTRONIC%20REPRINT%20PMID%2026057675.pdfTest; PUBMED: 26057675

الإتاحة: https://doi.org/10.1107/S139900471500704XTest
https://pasteur.hal.science/pasteur-02539010Test
https://pasteur.hal.science/pasteur-02539010/documentTest
https://pasteur.hal.science/pasteur-02539010/file/ELECTRONIC%20REPRINT%20PMID%2026057675.pdfTest

المؤلفون: Leclerc, Emilie, A., Huchenq, Anne, Kezic, S., Serre, Guy, Jonca, Nathalie

المساهمون: Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Coronel Institute of Occupational Health Amsterdam, The Netherlands (Academic Medical Center), Amsterdam Public Health Research Institute The Netherlands

المصدر: ISSN: 0021-9533.

مصطلحات موضوعية: Cornified cell envelope, Dermokine, Dmkn, Keratinocyte differentiation, Stratum corneum, MESH: Animals, MESH: Cell Differentiation / physiology, MESH: Mice, Mutant Strains, MESH: Protein Isoforms, MESH: Proteins / genetics, MESH: Proteins / metabolism, MESH: Epidermal Cells, MESH: Epidermis / metabolism, MESH: Female, MESH: Humans, MESH: Intercellular Signaling Peptides and Proteins, MESH: Keratinocytes / cytology, MESH: Keratinocytes / metabolism, MESH: Male, Inbred C57BL, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24794495; hal-03153791; https://ut3-toulouseinp.hal.science/hal-03153791Test; https://ut3-toulouseinp.hal.science/hal-03153791/documentTest; https://ut3-toulouseinp.hal.science/hal-03153791/file/Leclerc_2014.pdfTest; PUBMED: 24794495

الإتاحة: https://doi.org/10.1242/jcs.144808Test
https://ut3-toulouseinp.hal.science/hal-03153791Test
https://ut3-toulouseinp.hal.science/hal-03153791/documentTest
https://ut3-toulouseinp.hal.science/hal-03153791/file/Leclerc_2014.pdfTest

المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu

المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)

المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩

مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4Test
https://www.repository.cam.ac.uk/handle/1810/282947Test

المؤلفون: Dev, Harveer, Chiang, Ting-Wei Will, Lescale, Chloé, de Krijger, Inge, Martin, Alistair, Pilger, Domenic, Coates, Julia, Sczaniecka-Clift, Matylda, Wei, Wenming, Ostermaier, Matthias, Herzog, Mareike, Lam, Jonathan, Shea, Abigail, Demir, Mukerrem, Wu, Qian, Yang, Fengtang, Fu, Beiyuan, Lai, Zhongwu, Balmus, Gabriel, Belotserkovskaya, Rimma, Serra, Violeta, O’connor, Mark, Bruna, Alejandra, Beli, Petra, Pellegrini, Luca, Caldas, Carlos, Deriano, Ludovic, Jacobs, Jacqueline, Galanty, Yaron, Jackson, Stephen, T.

المساهمون: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge UK (CAM), Department of Biochemistry Cambridge, Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur Paris (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute Cambridge, Royaume-Uni (CRUK), Institute of Molecular Biology Mainz, Germany (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute Hinxton, UK, AstraZeneca US Waltham, USA, AstraZeneca Cambridge, UK, The Wellcome Trust Sanger Institute Cambridge, Vall d'Hebron Institute of Oncology Barcelone (VHIO), Vall d'Hebron University Hospital Barcelona, The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance

المصدر: ISSN: 1465-7392.

مصطلحات موضوعية: DNA damage and repair, Cancer, MESH: Animals, MESH: BRCA1 Protein / deficiency, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Female, MESH: BRCA1 Protein / genetics, MESH: HEK293 Cells, MESH: Humans, MESH: Mad2 Proteins / genetics, MESH: Mad2 Proteins / metabolism, MESH: Mice, MESH: Multiprotein Complexes, MESH: Osteosarcoma / drug therapy, MESH: Breast Neoplasms / pathology, MESH: Osteosarcoma / genetics, MESH: Osteosarcoma / metabolism, MESH: Osteosarcoma / pathology, MESH: Bone Neoplasms / drug therapy, MESH: Ovarian Neoplasms / drug therapy, MESH: Ovarian Neoplasms / genetics, MESH: Ovarian Neoplasms / metabolism, MESH: Ovarian Neoplasms / pathology, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Proteins / genetics, MESH: Cell Cycle Proteins, MESH: Proteins / metabolism, MESH: Recombinational DNA Repair, MESH: Telomere-Binding Proteins / genetics

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30022119; pasteur-02757608; https://pasteur.hal.science/pasteur-02757608Test; PUBMED: 30022119; PUBMEDCENTRAL: PMC6145444

الإتاحة: https://doi.org/10.1038/s41556-018-0140-1Test
https://pasteur.hal.science/pasteur-02757608Test

المؤلفون: Kostrzak, A, Caval, Vincent, Escande, M., Pliquet, E, Thalmensi, J, Bestetti, T, Julithe, M, Fiette, L, Huet, T, Wain-Hobson, Simon, Langlade-Demoyen, P

المساهمون: Invectys Paris, Rétrovirologie moléculaire - Molecular Retrovirology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Histopathologie humaine et Modèles animaux, Institut Pasteur Paris (IP), Université Sorbonne Paris Cité (USPC), Département Infection et Epidémiologie - Department of Infection and Epidemiology, This work was supported by Invectys.

المصدر: ISSN: 0969-7128.

مصطلحات موضوعية: Cancer therapy, Cytological techniques, Genetic engineering, Hydrolases, Melanoma, MESH: Animals, MESH: Cytidine Deaminase/genetics, MESH: Mice, Inbred C57BL, MESH: Plasmids/genetics, MESH: Proteins/genetics, MESH: Tumor Cells, Cultured, MESH: Electroporation/methods, MESH: Female, MESH: Genetic Therapy, MESH: Lymphocytes, Tumor-Infiltrating/immunology, MESH: Male, MESH: Melanoma, Experimental/genetics, Experimental/immunology, Experimental/therapy, [SDV]Life Sciences [q-bio], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BIO]Life Sciences [q-bio]/Biotechnology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27858943; pasteur-02545771; https://hal-pasteur.archives-ouvertes.fr/pasteur-02545771Test; PUBMED: 27858943

الإتاحة: https://doi.org/10.1038/gt.2016.77Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545771Test

المؤلفون: Vincent Caval, J Thalmensi, T Bestetti, E Pliquet, L Fiette, M Julithe, T. Huet, Anna Kostrzak, M Escande, Simon Wain-Hobson, Pierre Langlade-Demoyen

المساهمون: Invectys [Paris], Rétrovirologie moléculaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Histopathologie humaine et Modèles animaux, Institut Pasteur [Paris], Université Sorbonne Paris Cité (USPC), Département Infection et Epidémiologie - Department of Infection and Epidemiology, This work was supported by Invectys., Rétrovirologie moléculaire - Molecular Retrovirology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)

المصدر: Gene Therapy
Gene Therapy, Nature Publishing Group, 2017, 24 (2), pp.74-83. ⟨10.1038/gt.2016.77⟩
Gene Therapy, 2017, 24 (2), pp.74-83. ⟨10.1038/gt.2016.77⟩

مصطلحات موضوعية: 0301 basic medicine, Male, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Cancer therapy, Hydrolases, Genetic enhancement, [SDV]Life Sciences [q-bio], MESH: Electroporation/methods, Melanoma, Experimental, Mice, 0302 clinical medicine, Tumor Cells, Cultured, MESH: Animals, Fibrosarcoma, Melanoma, MESH: Lymphocytes, Tumor-Infiltrating/immunology, MESH: Cytidine Deaminase/genetics, Electroporation, MESH: Melanoma, Experimental/therapy, Cytidine deaminase, Cytological techniques, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Plasmids, Somatic hypermutation, Vectors in gene therapy, Gene delivery, Biology, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, MESH: Melanoma, Experimental/genetics, MESH: Mice, Inbred C57BL, Cytidine Deaminase, Genetics, medicine, MESH: Genetic Therapy, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Tumor Cells, Cultured, Molecular Biology, MESH: Mice, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Genetic Therapy, medicine.disease, Molecular biology, MESH: Male, Mice, Inbred C57BL, 030104 developmental biology, MESH: Proteins/genetics, Genetic engineering, MESH: Melanoma, Experimental/immunology, MESH: Plasmids/genetics, MESH: Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8487b68fc1c4afe01c1197b742d10a6Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545771Test

المؤلفون: Anne Bergeron, Paul Guertin, Jean-Stéphane Varré, Samuel Blanquart, Amandine Perrin, Krister M. Swenson

المساهمون: Bioinformatics and Sequence Analysis (BONSAI), Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire de combinatoire et d'informatique mathématique [Montréal] (LaCIM), Centre de Recherches Mathématiques [Montréal] (CRM), Université de Montréal (UdeM)-Université de Montréal (UdeM)-Université du Québec à Montréal = University of Québec in Montréal (UQAM), Collège André-Grasset [Montréal], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut de Biologie Computationnelle (IBC), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AB is partially supported by Canada NSERC Grant number 05729-2014, and by Équipes associées Inria-FRQNT Grant number 188128. This research is supported by the Inria Associate Team program.Inria associated team CG-ALCODE (2014-2016), Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: BMC Genomics
BMC Genomics, BioMed Central, 2016, Proceedings of the 14th Annual Research in Computational Molecular Biology (RECOMB) Comparative Genomics Satellite Workshop: genomics, 17 (Suppl 10), pp.786. ⟨10.1186/s12864-016-3103-6⟩
BMC Genomics, Vol 17, Iss S10, Pp 157-164 (2016)
BMC Genomics, 2016, Proceedings of the 14th Annual Research in Computational Molecular Biology (RECOMB) Comparative Genomics Satellite Workshop: genomics, 17 (Suppl 10), pp.786. ⟨10.1186/s12864-016-3103-6⟩

مصطلحات موضوعية: 0301 basic medicine, Eukaryotes, Proteomics, Genome, Transcriptome, MESH: RNA / metabolism, Mice, MESH: Proteins / chemistry, Protein Isoforms, MESH: Animals, Splicing orthologs, Genetics, MESH: Transcriptome, MESH: Alternative Splicing, MESH: Proteins / metabolism, Exons, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], RNA splicing, Transcriptome prediction, DNA microarray, MESH: RNA / chemistry, Algorithms, MESH: RNA / genetics, Biotechnology, MESH: Computational Biology, Gene isoform, lcsh:QH426-470, lcsh:Biotechnology, MESH: Protein Isoforms / genetics, Computational biology, Biology, MESH: Protein Isoforms / metabolism, 03 medical and health sciences, lcsh:TP248.13-248.65, MESH: Proteins / genetics, Animals, Humans, Gene, MESH: Mice, MESH: Protein Isoforms / chemistry, MESH: Humans, Alternative splicing, Computational Biology, Proteins, Alternative Splicing, lcsh:Genetics, 030104 developmental biology, MESH: Algorithms, RNA, MESH: Exons

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ff4b687c4cc8ff1a3f89934888a731Test
https://hal.inria.fr/hal-01396410Test

المؤلفون: Patrick Weber, Mireille Nowakowski, Isabelle Miras, Mathieu Picardeau, William Shepard, Frederick Saul, Ahmed Haouz

المساهمون: Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Production de Protéines Recombinantes (Plate-Forme) (PRPF), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Biologie des Spirochètes / Biology of Spirochetes, Institut Pasteur [Paris], This work was supported by the Institut Pasteur and the French Ministry of Research (ANR-08-MIE-018)., We acknowledge access to the PROXIMA1 beamline at SOLEIL and the support from its staff. We thank Jacques Bellalou for assistance in protein-production optimization and Vincent Bondet for protein purification at an early stage of the work (PFPR, Institut Pasteur), ANR-08-MIEN-0018,LEPTOVIR,Les leptospires : de la génétique à la pathogénèse(2008), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)

المصدر: Acta Crystallographica Section D: Biological Crystallography
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2015, 71 (6), pp.1351-1359. ⟨10.1107/S139900471500704X⟩
Acta crystallographica Section D : Structural biology [1993-...]
Acta crystallographica Section D : Structural biology [1993-..], 2015, 71 (6), pp.1351-1359. ⟨10.1107/S139900471500704X⟩

مصطلحات موضوعية: LRR motif, crystal structure, MESH: Leptospira interrogans/chemistry, Subfamily, Protein Conformation, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Human pathogen, chemical and pharmacologic phenomena, spirochaetes, MESH: Amino Acid Sequence, medicine.disease_cause, Crystallography, X-Ray, Leucine-Rich Repeat Proteins, Genome, Microbiology, 03 medical and health sciences, MESH: Protein Conformation, Bacterial Proteins, Structural Biology, Leptospira, medicine, MESH: Proteins/genetics, MESH: Cloning, Molecular, Amino Acid Sequence, Cloning, Molecular, Structural motif, Gene, MESH: Bacterial Proteins, 030304 developmental biology, Genetics, 0303 health sciences, MESH: Molecular Sequence Data, biology, 030306 microbiology, fungi, Proteins, Pathogenic bacteria, General Medicine, biology.organism_classification, MESH: Crystallography, X-Ray, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Leptospira interrogans

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181ce67719d8c6537a6af49774b710adTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-02539010Test

المؤلفون: Nathalie Jonca, Anne Huchenq, Guy Serre, Emilie Leclerc, Sanja Kezic

المساهمون: Amsterdam Public Health, Coronel Institute of Occupational Health, CARBILLET, Véronique, Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Coronel Institute of Occupational Health [Amsterdam, The Netherlands] (Academic Medical Center), Amsterdam Public Health Research Institute [The Netherlands]

المصدر: Journal of cell science, 127(Part 13), 2862-2872. Company of Biologists Ltd
Journal of Cell Science
Journal of Cell Science, 2014, 127 (13), pp.2862-2872. ⟨10.1242/jcs.144808⟩
Journal of Cell Science, Company of Biologists, 2014, 127 (13), pp.2862-2872. ⟨10.1242/jcs.144808⟩

مصطلحات موضوعية: Keratinocytes, Male, MESH: Mice, Mutant Strains, Stratum corneum, Filaggrin Proteins, MESH: Protein Isoforms, MESH: Epidermal Cells, Mice, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Protein Isoforms, Genetics, chemistry.chemical_classification, MESH: Keratinocytes / metabolism, Dmkn, MESH: Proteins / metabolism, Cell Differentiation, MESH: Cell Differentiation / physiology, Phenotype, Amino acid, Cell biology, Dermokine, MESH: Proteins / genetics, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Intercellular Signaling Peptides and Proteins, MESH: Animals, Female, Intracellular, Filaggrin, Gene isoform, Biology, MESH: Keratinocytes / cytology, MESH: Mice, Inbred C57BL, Animals, Humans, MESH: Intercellular Signaling Peptides and Proteins, Gene, Involucrin, MESH: Mice, Cornified cell envelope, Messenger RNA, MESH: Humans, Keratinocyte differentiation, Proteins, Cell Biology, Mice, Mutant Strains, MESH: Male, MESH: Epidermis / metabolism, Mice, Inbred C57BL, chemistry, Epidermal Cells, Epidermis, MESH: Female

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076cfa563f3364839204565896569774Test
https://pure.amc.nl/en/publications/mice-deficient-for-the-epidermal-dermokine--and--isoforms-display-transient-cornification-defectsTest(df4b76ca-0828-4b59-a52c-ae84d20f7a3e).html