المؤلفون: Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David

المساهمون: UMR - Interactions Plantes Microorganismes Environnement (UMR IPME), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud ), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: Somatic embryogenesis, Coffee, High throughput optimization, Automated screening system, Active compounds, MESH: Automation, Laboratory, MESH: Coffea / cytology, MESH: Quinolines / pharmacology, MESH: Reproducibility of Results, MESH: Seeds / cytology, MESH: Seeds / drug effects, MESH: Seeds / growth & development, MESH: Coffea / drug effects, MESH: Hight-Throughput Screening Assays / instrumentation, MESH: Hight-Throughput Screening Assays / methods, MESH: Histone Deacetylase inhibitors / pharmacology, MESH: Hydroxamic Acids / pharmacology, MESH: Hydroxylamines / pharmacology, MESH: Miniaturization, MESH: Pilot Projects, MESH: Plant Cells / drug effects, MESH: Plant Somatic Embryogenesis Techniques / methods, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31965007; hal-03454869; https://hal.umontpellier.fr/hal-03454869Test; https://hal.umontpellier.fr/hal-03454869/documentTest; https://hal.umontpellier.fr/hal-03454869/file/s41598-020-57800-6.pdfTest; PUBMED: 31965007; PUBMEDCENTRAL: PMC6972844; WOS: 000512142100048

الإتاحة: https://doi.org/10.1038/s41598-020-57800-6Test
https://hal.umontpellier.fr/hal-03454869Test
https://hal.umontpellier.fr/hal-03454869/documentTest
https://hal.umontpellier.fr/hal-03454869/file/s41598-020-57800-6.pdfTest

المؤلفون: Simoben, Conrad, Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith, Pierce, Raymond, J., Romier, Christophe, Jung, Manfred, Sippl, Wolfgang

المساهمون: Martin-Luther-Universität Halle Wittenberg (MLU), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work and the authors of this article received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration under Grant Agreements 241865 (SEtTReND) and 602080 (A-ParaDDisE). Further support was received by the Deutsche Forschungsgemeinschaft (Ju-295/13-1, SI-868/13-1). MM, TBS and CR are supported by institutional funds from the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université de Strasbourg., The authors acknowledge the support and the use of resources of the French Infrastructure for Integrated Structural Biology FRISBI ANR-10-INBS-05 and of Instruct-ERIC. We wish to thank members of the ESRF-EMBL joint structural biology groups and the SOLEIL synchrotron for the use of their beamline facilities and for help during data collection. We are grateful to Pierre Legrand (SOLEIL) for his kind assistance for data processing

المصدر: ISSN: 1420-3049 ; Molecules ; https://hal.science/hal-02391176Test ; Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩.

مصطلحات موضوعية: crystal structure, docking, epigenetics, histone deacetylase (HDAC) inhibitors, schistosomiasis, virtual screening, MESH: Animals, MESH: Anthelmintics/pharmacology, MESH: Hydroxamic Acids/chemical synthesis, MESH: Hydroxamic Acids/pharmacology, MESH: Apoptosis/drug effects, MESH: Molecular Docking Simulation, MESH: Protein Binding, MESH: Protein Interaction Domains and Motifs, MESH: Protein Structure, Secondary, MESH: Pyrrolidines/chemical synthesis, MESH: Pyrrolidines/pharmacology, MESH: Schistosoma mansoni/drug effects, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/enzymology, MESH: Schistosoma mansoni/genetics, MESH: Schistosoma mansoni/growth & development, MESH: Binding Sites, MESH: Structure-Activity Relationship, MESH: Zinc/chemistry, MESH: Zinc/metabolism, MESH: Chelating Agents/chemical synthesis, MESH: Anthelmintics/chemical synthesis, MESH: Chelating Agents/pharmacology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29498707; hal-02391176; https://hal.science/hal-02391176Test; https://hal.science/hal-02391176/documentTest; https://hal.science/hal-02391176/file/A_Novel_Class_of_Schistosoma_mansoni_Histone_Deacetylase_8_%28HDAC8%29_Inhibitors_Identified.pdfTest; PUBMED: 29498707; PUBMEDCENTRAL: PMC6017931

الإتاحة: https://doi.org/10.3390/molecules23030566Test
https://hal.science/hal-02391176Test
https://hal.science/hal-02391176/documentTest
https://hal.science/hal-02391176/file/A_Novel_Class_of_Schistosoma_mansoni_Histone_Deacetylase_8_%28HDAC8%29_Inhibitors_Identified.pdfTest

المؤلفون: Déprez-Poulain, Rebecca, Hennuyer, Nathalie, Bosc, Damien, Liang, Wenguang, Enée, Emmanuelle, Marechal, Xavier, Charton, Julie, Totobenazara, Jane, Berte, Gonzague, Jahklal, Jouda, Verdelet, Tristan, Dumont, Julie, Dassonneville, Sandrine, Woitrain, Eloise, Gauriot, Marion, Paquet, Charlotte, Duplan, Isabelle, Hermant, Paul, Cantrelle, François- Xavier, Sevin, Emmanuel, Culot, Maxime, Landry, Valérie, Herledan, Adrien, Piveteau, Catherine, Lippens, Guy, Leroux, Florence, Tang, Wei-Jen, van Endert, Peter, Staels, Bart, Déprez, Benoit

المساهمون: Biostructures et Decouverte de Medicament, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Réseau International des Instituts Pasteur (RIIP), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), The University of Chicago Medicine Chicago, Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UA), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 (M2SV), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Ben May Institute Cancer Research, University of Chicago, Université Paris Descartes - Paris 5 (UPD5), The authors acknowledge support from Qing Guo for technical assistance and Hélène Gras-Masse for fruitful discussions. INSERM, University of Lille 2, Institut Pasteur de Lille, Region Nord Pas de Calais, EDFR, Etat (0823007, 0823008, 07-CPER 009-01, 2007-0172-02-CPER/3), Foundation pour la Recherche Médicale (grant DCM20111223046), National Institute of Health (GM81539), and Institute of Translational Medicine (CTSA UL1 TR000430), Agence Nationale de la recherche (grant ANR-11-JS07-015-01) are thanked for funding. M.G. and G.B. are recipients of a fellowship from Ministère de la Recherche et de l′Enseignement Supérieur. Structure results are derived from work performed at Argonne National Laboratory, Structural Biology Center at the Advanced Photon Source. Argonne is operated by UChicago Argonne, LLC, for the U.S. Department of Energy, Office of Biological and Environmental Research under contract DE-AC02-06CH11357

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: MESH: Animals, MESH: Caco-2 Cells, MESH: Hydroxamic Acids/chemical synthesis, MESH: Hydroxamic Acids/pharmacology, MESH: Insulysin/antagonists & inhibitors, MESH: Hydroxamic Acids/therapeutic use, MESH: Male, MESH: Mice, Inbred C57BL, MESH: Microsomes, Liver, MESH: Molecular Targeted Therapy, MESH: Random Allocation, MESH: Triazoles/chemical synthesis, MESH: Structure-Activity Relationship, MESH: Triazoles/pharmacology, MESH: Catalytic Domain, MESH: Triazoles/therapeutic use, MESH: Diabetes Mellitus/drug therapy, MESH: Drug Evaluation, Preclinical, MESH: Glucose Tolerance Test, MESH: Humans, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26394692; hal-02511111; https://univ-artois.hal.science/hal-02511111Test; https://univ-artois.hal.science/hal-02511111/documentTest; https://univ-artois.hal.science/hal-02511111/file/catalyting_site_inhibition_of_insulin_degrading.pdfTest; PUBMED: 26394692; PUBMEDCENTRAL: PMC4580987

الإتاحة: https://doi.org/10.1038/ncomms9250Test
https://univ-artois.hal.science/hal-02511111Test
https://univ-artois.hal.science/hal-02511111/documentTest
https://univ-artois.hal.science/hal-02511111/file/catalyting_site_inhibition_of_insulin_degrading.pdfTest

المؤلفون: Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek

المساهمون: Romier, Christophe, Martin-Luther-Universität Halle Wittenberg (MLU), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work and the authors of this article received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration under Grant Agreements 241865 (SEtTReND) and 602080 (A-ParaDDisE). Further support was received by the Deutsche Forschungsgemeinschaft (Ju-295/13-1, SI-868/13-1). MM, TBS and CR are supported by institutional funds from the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université de Strasbourg., The authors acknowledge the support and the use of resources of the French Infrastructure for Integrated Structural Biology FRISBI ANR-10-INBS-05 and of Instruct-ERIC. We wish to thank members of the ESRF-EMBL joint structural biology groups and the SOLEIL synchrotron for the use of their beamline facilities and for help during data collection. We are grateful to Pierre Legrand (SOLEIL) for his kind assistance for data processing, Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

المصدر: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, MESH: Helminth Proteins/metabolism, MESH: Histone Deacetylases/metabolism, MESH: Histone Deacetylases/genetics, Pharmaceutical Science, MESH: Protein Structure, Secondary, Gene Expression, Apoptosis, Crystallography, X-Ray, Hydroxamic Acids, Molecular Docking Simulation, MESH: Helminth Proteins/antagonists & inhibitors, MESH: Chelating Agents/chemical synthesis, Protein Structure, Secondary, Analytical Chemistry, 0302 clinical medicine, MESH: Structure-Activity Relationship, MESH: Hydroxamic Acids/chemical synthesis, Drug Discovery, MESH: Zinc/metabolism, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Histone Deacetylase Inhibitors/pharmacology, Chelating Agents, Anthelmintics, biology, Chemistry, MESH: Anthelmintics/pharmacology, Helminth Proteins, Schistosoma mansoni, epigenetics, crystal structure, docking, histone deacetylase (HDAC) inhibitors, schistosomiasis, virtual screening, MESH: Histone Deacetylases/chemistry, 3. Good health, MESH: Schistosoma mansoni/drug effects, MESH: Pyrrolidines/pharmacology, Zinc, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Protein Binding, MESH: Apoptosis/drug effects, MESH: Gene Expression, In silico, 030231 tropical medicine, MESH: Zinc/chemistry, Article, Histone Deacetylases, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Molecular Docking Simulation, Structure–activity relationship, MESH: Protein Binding, Animals, MESH: Helminth Proteins/genetics, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, MESH: Histone Deacetylase Inhibitors/chemical synthesis, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Virtual screening, MESH: Protein Interaction Domains and Motifs, Binding Sites, Organic Chemistry, MESH: Hydroxamic Acids/pharmacology, HDAC8, MESH: Schistosoma mansoni/growth & development, Epigenome, biology.organism_classification, MESH: Crystallography, X-Ray, MESH: Anthelmintics/chemical synthesis, Histone Deacetylase Inhibitors, 030104 developmental biology, MESH: Binding Sites, Docking (molecular), MESH: Chelating Agents/pharmacology, MESH: Schistosoma mansoni/enzymology, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/genetics, MESH: Pyrrolidines/chemical synthesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994bTest
http://europepmc.org/articles/PMC6017931Test