المؤلفون: Alvarez-Dorta, Dimitri, King, Dustin, Legigan, Thibaut, Ide, Daisuke, Adachi, Isao, Deniaud, David, Desire, Jerome, Kato, Atsushi, Vocadlo, David, Gouin, Sébastien, G., Blériot, Yves

المساهمون: Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Simon Fraser University = Université Simon Fraser (SFU.ca), Institut de chimie des milieux et matériaux de Poitiers UMR 7285 (IC2MP Poitiers ), Université de Poitiers = University of Poitiers (UP)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Hospital Pharmacy Toyama, University of Toyama

المصدر: ISSN: 0947-6539.

مصطلحات موضوعية: exo-N-acetyl-β-glucosaminidases, glycoclusters, glycosidases, iminosugars, multivalency, MESH: Animals, MESH: Anti-Bacterial Agents / chemistry, MESH: Imino Sugars / chemistry, MESH: Imino Sugars / pharmacology, MESH: Plants / metabolism, MESH: Anti-Bacterial Agents / pharmacology, MESH: Azepines / chemistry, MESH: Azepines / pharmacology, MESH: Cyclodextrins / chemistry, MESH: Enzyme Inhibitors / metabolism, MESH: Ethylene Glycol / chemistry, MESH: Glucosides / chemistry, MESH: Hexosaminidases / antagonists & inhibitors, [CHIM]Chemical Sciences, [CHIM.ORGA]Chemical Sciences/Organic chemistry

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28548311; hal-01744683; https://hal.science/hal-01744683Test; https://hal.science/hal-01744683/documentTest; https://hal.science/hal-01744683/file/multivalency_to_inhibit_and_discriminate_hexosaminidases.pdfTest; PUBMED: 28548311

الإتاحة: https://doi.org/10.1002/chem.201701756Test
https://hal.science/hal-01744683Test
https://hal.science/hal-01744683/documentTest
https://hal.science/hal-01744683/file/multivalency_to_inhibit_and_discriminate_hexosaminidases.pdfTest

المؤلفون: Paoletti, Julie, Assairi, Liliane, Gelin, Muriel, Huteau, Valerie, Nahori, Marie -Anne, Dussurget, Olivier, Labesse, Gilles, Pochet, Sylvie

المساهمون: Chimie et Biocatalyse, Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), U759 Unité Imagerie intégrative, Institut Curie Paris, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Biochimie Structurale Montpellier (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Interactions Bactéries-Cellules (UIBC), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Agence Nationale de la Recherche ANR-06-BLAN-0324, ANR-11-EMM-0019, French Infrastructure for Integrated Structural Biology (FRISBI) ANR-10-INSB-05-01, ANR ANR-11-EMM-0019, ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), ANR-11-EMMA-0019,ANAKIN (Anti-NAd-Kinase),Nouveaux composés antibactériens ciblant la NAD kinase(2011), ANR-06-BLAN-0324,Gram(+) NADK,Rational design and in situ selection of drug targetting NAD kinases from Gram(+) bacterial pathogens(2006)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: Adenosine analogue, Antibacterial, Inhibitor, NAD kinase, X-ray crystallography, MESH: Adenosine/chemistry, MESH: Adenosine/metabolism, MESH: Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors, MESH: Phosphotransferases (Alcohol Group Acceptor)/chemistry, MESH: Phosphotransferases (Alcohol Group Acceptor)/metabolism, MESH: Protein Binding, MESH: Protein Conformation, MESH: Ribose/chemistry, MESH: Staphylococcus aureus/enzymology, MESH: Structure-Activity Relationship, MESH: Adenosine/pharmacology, MESH: Amino Acid Sequence, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/metabolism, MESH: Enzyme Inhibitors/pharmacology, MESH: Humans, MESH: Listeria monocytogenes/enzymology, MESH: Molecular Docking Simulation, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27783975; hal-01606966; https://hal.science/hal-01606966Test; PRODINRA: 387353; PUBMED: 27783975; WOS: 000388544600082

الإتاحة: https://doi.org/10.1016/j.ejmech.2016.10.033Test
https://hal.science/hal-01606966Test

المؤلفون: Julie Paoletti, Gilles Labesse, Olivier Dussurget, Marie Anne Nahori, Liliane Assairi, Sylvie Pochet, Muriel Gelin, Valérie Huteau

المساهمون: Chimie et Biocatalyse, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), U759 Unité Imagerie intégrative, Institut Curie, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Interactions Bactéries-Cellules (UIBC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Institut National de la Recherche Agronomique (INRA), Université Sorbonne Paris Cité (USPC), Agence Nationale de la Recherche [ANR-06-BLAN-0324, ANR-11-EMM-0019], French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INSB-05-01], ANR [ANR-11-EMM-0019], ANR-10-INBS-05-01/10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), ANR-11-EMMA-0019,ANAKIN (Anti-NAd-Kinase),Nouveaux composés antibactériens ciblant la NAD kinase(2011), ANR-06-BLAN-0324,Gram(+) NADK,Rational design and in situ selection of drug targetting NAD kinases from Gram(+) bacterial pathogens(2006), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩

مصطلحات موضوعية: 0301 basic medicine, Adenosine, MESH: Adenosine/chemistry, Protein Conformation, Ribose, [SDV]Life Sciences [q-bio], MESH: Staphylococcus aureus/enzymology, MESH: Amino Acid Sequence, MESH: Ribose/chemistry, Nicotinamide adenine dinucleotide, 01 natural sciences, MESH: Adenosine/pharmacology, chemistry.chemical_compound, MESH: Protein Conformation, MESH: Structure-Activity Relationship, Drug Discovery, Transferase, Enzyme Inhibitors, MESH: Listeria monocytogenes/enzymology, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Kinase, General Medicine, MESH: Phosphotransferases (Alcohol Group Acceptor)/metabolism, Molecular Docking Simulation, 010101 applied mathematics, Phosphotransferases (Alcohol Group Acceptor), Biochemistry, Phosphorylation, Nicotinamide adenine dinucleotide phosphate, Protein Binding, medicine.drug, Staphylococcus aureus, Inhibitor, MESH: Phosphotransferases (Alcohol Group Acceptor)/chemistry, Stereochemistry, Cofactor, Structure-Activity Relationship, 03 medical and health sciences, MESH: Adenosine/metabolism, Adenosine analogue, MESH: Molecular Docking Simulation, medicine, Humans, MESH: Protein Binding, Amino Acid Sequence, MESH: Enzyme Inhibitors/chemistry, 0101 mathematics, NAD kinase, X-ray crystallography, Pharmacology, MESH: Humans, MESH: Enzyme Inhibitors/pharmacology, Organic Chemistry, MESH: Enzyme Inhibitors/metabolism, Listeria monocytogenes, Antibacterial, 030104 developmental biology, chemistry, biology.protein, NAD+ kinase, MESH: Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e165d3eae566bd9b213507978bbd048aTest
https://doi.org/10.1016/j.ejmech.2016.10.033Test

المؤلفون: François-Xavier Cantrelle, Jamal Khalife, Isabelle Landrieu, Alain Martoriati, Katia Cailliau-Maggio, Jérôme Vicogne, Aline Fréville, Géraldine Tellier, Christine Pierrot, Audrey Vandomme

المساهمون: Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Lille Nord de France (COMUE), Laboratoire de Régulation des Signaux de Division, Université de Lille, Sciences et Technologies, The NMR facilities were funded by the Région Nord, CNRS, Pasteur Institute of Lille, European Community (FEDER), French Research Ministry and the University of Sciences and Technologies of Lille I. We gratefully acknowledge support from the TGIR‐RMN‐THC FR3050 CNRS., We thank Hadidjatou Kalamou for technical assistance. We thank Dr RJ Pierce for critical reading of the manuscript., Centre d’Infection et d’Immunité de Lille (CIIL) - U1019 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Université de Lille-Centre National de la Recherche Scientifique (CNRS)

المصدر: FEBS Journal
FEBS Journal, Wiley, 2014, 281 (19), pp.4519-4534. ⟨10.1111/febs.12960⟩
FEBS Journal, 2014, 281 (19), pp.4519-4534. ⟨10.1111/febs.12960⟩

مصطلحات موضوعية: Erythrocytes, Amino Acid Motifs, Drug Evaluation, Preclinical, Protozoan Proteins, Xenopus, Regulator, protein phosphatase type 1, Peptide, MESH: Amino Acid Sequence, MESH: Protein Phosphatase 1/physiology, Biochemistry, Homology (biology), MESH: Protozoan Proteins/chemistry, protein-protein interaction, Xenopus laevis, MESH: Amino Acid Motifs, Protein Phosphatase 1, MESH: Antimalarials/pharmacology, MESH: Animals, Enzyme Inhibitors, Cells, Cultured, MESH: Antimalarials/chemistry, chemistry.chemical_classification, 0303 health sciences, 030302 biochemistry & molecular biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], MESH: Drug Evaluation, Preclinical, MESH: Plasmodium falciparum/enzymology, Protein Binding, MESH: Cells, Cultured, PP1 inhibitor 2, MESH: Plasmodium falciparum/drug effects, MESH: Protein Phosphatase 1/chemistry, Immunoprecipitation, Molecular Sequence Data, Phosphatase, Plasmodium falciparum, Biology, MESH: Protein Phosphatase 1/antagonists & inhibitors, Protein–protein interaction, Antimalarials, 03 medical and health sciences, NMR spectroscopy, MESH: Xenopus laevis, Animals, Humans, MESH: Protein Binding, Protein Interaction Domains and Motifs, Amino Acid Sequence, MESH: Enzyme Inhibitors/chemistry, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Molecular Biology, 030304 developmental biology, MESH: Protozoan Proteins/antagonists & inhibitors, MESH: Protein Interaction Domains and Motifs, Germinal vesicle, MESH: Humans, MESH: Molecular Sequence Data, MESH: Enzyme Inhibitors/pharmacology, MESH: Enzyme Inhibitors/metabolism, Cell Biology, biology.organism_classification, MESH: Antimalarials/metabolism, chemistry, MESH: Protozoan Proteins/physiology, MESH: Erythrocytes/parasitology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7ae8399958cd3d07fc17449374a761Test
https://hal.archives-ouvertes.fr/hal-01077866Test

المؤلفون: Amiable, Claire, Paoletti, Julie, Haouz, Ahmed, Padilla, André, Labesse, Gilles, Kaminski, Pierre-Alexandre, Pochet, Sylvie

المساهمون: Université Paris Descartes - Paris 5 (UPD5), Chimie et Biocatalyse, Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Biochimie Structurale Montpellier (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the Fondation pour la Recherche Médicale (DCM20111223063 to S. Pochet), Institut Pasteur, CNRS, INSERM and the French Infrastructure for Integrated Structural Biology (FRISBI, ANR-10-INSB-05-01)., ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: Cancer, Cross-coupling reaction, Crystal structure, DNPH1, Inhibitor, Nucleoside analogues, MESH: Animals, MESH: Antineoplastic Agents/chemical synthesis, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/metabolism, MESH: Enzyme Inhibitors/pharmacology, MESH: Humans, MESH: Molecular Docking Simulation, MESH: Molecular Targeted Therapy, MESH: N-Glycosyl Hydrolases/antagonists & inhibitors, MESH: N-Glycosyl Hydrolases/chemistry, MESH: N-Glycosyl Hydrolases/metabolism, MESH: Nuclear Proteins/antagonists & inhibitors, MESH: Antineoplastic Agents/chemistry, MESH: Nuclear Proteins/chemistry, MESH: Nuclear Proteins/metabolism, MESH: Protein Conformation, MESH: Proto-Oncogene Proteins/antagonists & inhibitors, MESH: Proto-Oncogene Proteins/chemistry, MESH: Proto-Oncogene Proteins/metabolism, MESH: Purine Nucleotides/chemical synthesis, MESH: Purine Nucleotides/chemistry, MESH: Purine Nucleotides/metabolism, MESH: Purine Nucleotides/pharmacology, MESH: Antineoplastic Agents/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25108359; pasteur-01483767; https://pasteur.hal.science/pasteur-01483767Test; PUBMED: 25108359

الإتاحة: https://doi.org/10.1016/j.ejmech.2014.07.110Test
https://pasteur.hal.science/pasteur-01483767Test