المؤلفون: Sutcu, Haser, H, Rassinoux, Phoebe, Donnio, Lise-Marie, Neuillet, Damien, Vianna-Legros, François, Gabillot, Olivier, Mari, Pierre-Olivier, Baldeyron, Céline, Giglia-Mari, Giuseppina

المساهمون: Laboratoire de Radiobiologie des expositions accidentelles (IRSN/PSE-SANTE/SERAMED/LRAcc), Service de recherche en radiobiologie et en médecine régénérative (IRSN/PSE-SANTE/SERAMED), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pathophysiologie et génétique du neurone et du muscle (PGNM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de micro-irradiation, de métrologie et de dosimétrie neutrons (IRSN/PSE-SANTE/SDOS/LMDN), Service de dosimétrie (IRSN/PSE-SANTE/SDOS), AFM-Téléthon, France (Plan stratégique MyoNeurAlp 1 and MyoNeurAlp 2), Institut National du Cancer PLBIO19-126 LS194750 INCa 2019, Ligue Contre les Cancers, France (Regional grant AURA)

المصدر: ISSN: 2575-1077 ; Life Science Alliance ; https://hal.science/hal-04302036Test ; Life Science Alliance, 2023, 7 (2), pp.e202302279. ⟨10.26508/lsa.202302279⟩.

مصطلحات موضوعية: MESH: DNA Repair, MESH: DNA Damage, MESH: DNA End-Joining Repair, MESH: Cell Differentiation, MESH: DNA, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37993260; hal-04302036; https://hal.science/hal-04302036Test; https://hal.science/hal-04302036v2/documentTest; https://hal.science/hal-04302036v2/file/Decline%20of%20DNA%20damage%20response%20along%20with%20myogenic%20differentiation.pdfTest; PUBMED: 37993260; PUBMEDCENTRAL: PMC10665522

الإتاحة: https://doi.org/10.26508/lsa.202302279Test
https://hal.science/hal-04302036Test
https://hal.science/hal-04302036v2/documentTest
https://hal.science/hal-04302036v2/file/Decline%20of%20DNA%20damage%20response%20along%20with%20myogenic%20differentiation.pdfTest

المؤلفون: Vincendeau, Estelle, Wei, Wenming, Zhang, Xuefei, Planchais, Cyril, Yu, Wei, Lenden-Hasse, Hélène, Cokelaer, Thomas, Pipoli da Fonseca, Juliana, Mouquet, Hugo, Adams, David, Alt, Frederick, Jackson, Stephen, Balmus, Gabriel, Lescale, Chloé, Deriano, Ludovic

المساهمون: Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Howard Hughes Medical Institute (HHMI), Peking University Beijing, Immunologie humorale - Humoral Immunology, Biomics (plateforme technologique), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, The Wellcome Trust Sanger Institute Cambridge, University of Cambridge UK (CAM), The Deriano laboratory is funded by Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (Inserm), Wordwide Cancer Research (grant # 19-0333), Ligue Nationale Contre le Cancer (Equipe labellisée 2019), and Institut National du Cancer (INCa, grant # PLBIO19-122). E.V. is supported by the French Ministry of Higher Education, Research, and Innovation (Doctoral School Bio Sorbonne Paris Cité) and by the Fondation pour la Recherche Médicale. W.W. is part of the Pasteur–Paris University International Ph.D. program and received funding from the CNBG company, China. The Balmus laboratory at the UK DRI is funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. Research in the Jackson laboratory is funded by Cancer Research UK (CRUK) program grant DRCPGM\100005 and core grant C6946/A24843, Wellcome Investigator award 206388/Z/17/Z and core grant 203144, and ERC Synergy award 855741. S.P.J. receives a salary from the University of Cambridge. F.W.A is an investigator of the Howard Hughes Medical Institute. H.M. received core grants from the Institut Pasteur, the INSERM and the Milieu Intérieur Program (ANR-10-LABX-69-01)., We thank the Wellcome Trust Sanger Institute Mouse Genetics Project (Sanger MGP) and its funders for providing the mutant mouse line (Allele: Shld1em1(IMPC)Wtsi), and INFRAFRONTIER/EMMA. We thank the Institut Pasteur animal facility, specifically Quentin Mille, Jeromine Rohard Blanco, and Franck Bourgade for mouse weighing. We thank Jean-Pierre de Villartay for providing the CD21-Cre3a line and Klaus Rajewsky and MGC for permission to use the line. We thank Michela Di Virgilio for providing 53BP1 knockout animals and Junjie Chen for permission to use them. We thank members of the Deriano lab for their discussion and technical help. We thank Bernardo Reina-San-Martin for the discussion and advices. We thank Christopher Carnie for the discussion on the design of SHLD1 mutant sites., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010)

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins, MESH: Immunoglobulin Class Switching, MESH: V(D)J Recombination, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35764636; pasteur-04120567; https://pasteur.hal.science/pasteur-04120567Test; https://pasteur.hal.science/pasteur-04120567/documentTest; https://pasteur.hal.science/pasteur-04120567/file/s41467-022-31287-3.pdfTest; PUBMED: 35764636; PUBMEDCENTRAL: PMC9240092

الإتاحة: https://doi.org/10.1038/s41467-022-31287-3Test
https://pasteur.hal.science/pasteur-04120567Test
https://pasteur.hal.science/pasteur-04120567/documentTest
https://pasteur.hal.science/pasteur-04120567/file/s41467-022-31287-3.pdfTest

المؤلفون: Yu, Wei, Lescale, Chloé, Babin, Loelia, Bedora-Faure, Marie, Lenden-Hasse, Hélène, Baron, Ludivine, Demangel, Caroline, Yelamos, José, Brunet, Erika, Deriano, Ludovic

المساهمون: Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur Paris (IP), Genome dynamics in the immune system (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia, This project is funded by the Institut Pasteur (L.D. and C.D. labs), the Institut National du Cancer (INCa Grant # PLBIO16-181 to L.D. and E.B. labs), the Ligue Nationale Contre le Cancer (Équipe Labellisée 2019 L.D. lab and Équipe Labellisée 2017 and 2020 E.B. lab) the Cancéropôle IdF-INCa (Emergence 2016 grant to L.D. and C.D.), the Spanish Ministerio de Economía, Industria y Competitividad (Grant SAF2017-83565-R to J.Y.) as well as by the Fundación Científica de la Asociación Española Contra el Cáncer (AECC) (Grant PROYEI6018YÉLA to J.Y.)., We thank the Institut Pasteur genomics and cytometry platforms for help with sequencing and cell sorting, Frederick Alt and members of his lab for tremendous help with LAM-HTGTS experiments, Barry Sleckman for providing the RAG2-Thy1.1 complementation vector, Joy Bianchi for providing the Rag2−/− p53−/− v-Abl pro-B cell lines, Carine Giovannangeli and Anne de Cian for providing the Cas9 protein and Thomas Mercher for helpful discussions and suggestions.

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: MESH: Animals, MESH: Cell Cycle, MESH: DNA Breaks, Double-Stranded, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins, MESH: G1 Phase, MESH: Mice, MESH: Poly (ADP-Ribose) Polymerase-1, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33067475; pasteur-03262335; https://pasteur.hal.science/pasteur-03262335Test; https://pasteur.hal.science/pasteur-03262335/documentTest; https://pasteur.hal.science/pasteur-03262335/file/s41467-020-19060-w.pdfTest; PUBMED: 33067475; PUBMEDCENTRAL: PMC7567796

الإتاحة: https://doi.org/10.1038/s41467-020-19060-wTest
https://pasteur.hal.science/pasteur-03262335Test
https://pasteur.hal.science/pasteur-03262335/documentTest
https://pasteur.hal.science/pasteur-03262335/file/s41467-020-19060-w.pdfTest

المؤلفون: Mosbach, Valentine, Viterbo, David, Descorps-Declère, Stéphane, Poggi, Lucie, Vaysse-Zinkhöfer, Wilhelm, Richard, Guy-Franck

المساهمون: Génétique des génomes - Genetics of Genomes (UMR 3525), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Collège Doctoral, Sorbonne Université (SU), V. M. was supported by Fondation Guy Nicolas and Fondation Hardy. W. V.-Z. is the recipient of a PhD fellowship from la Ligue Nationale Contre le Cancer. This work was generously supported by the Institut Pasteur and by the Centre National de la Recherche Scientifique (CNRS).

المصدر: ISSN: 1553-7390.

مصطلحات موضوعية: MESH: CRISPR-Associated Protein 9, MESH: CRISPR-Cas Systems, MESH: Gene Conversion, MESH: Genome, Human, MESH: Humans, MESH: Myotonic Dystrophy, MESH: Rad52 DNA Repair and Recombination Protein, MESH: Recombination, Genetic, MESH: Saccharomyces cerevisiae, MESH: Saccharomyces cerevisiae Proteins, MESH: Trinucleotide Repeat Expansion, MESH: Trinucleotide Repeats, MESH: Chromosome Deletion, MESH: Chromosomes, Fungal, MESH: DNA Breaks, Double-Stranded, MESH: DNA End-Joining Repair, MESH: DNA Ligase ATP, MESH: DNA Repair, MESH: DNA-Binding Proteins, MESH: Endonucleases, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32673314; pasteur-03657831; https://pasteur.hal.science/pasteur-03657831Test; https://pasteur.hal.science/pasteur-03657831/documentTest; https://pasteur.hal.science/pasteur-03657831/file/2020-Mosbach%20%28PLoS%20Genetics%29.pdfTest; PUBMED: 32673314; PUBMEDCENTRAL: PMC7413560

الإتاحة: https://doi.org/10.1371/journal.pgen.1008924Test
https://pasteur.hal.science/pasteur-03657831Test
https://pasteur.hal.science/pasteur-03657831/documentTest
https://pasteur.hal.science/pasteur-03657831/file/2020-Mosbach%20%28PLoS%20Genetics%29.pdfTest

المؤلفون: Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano

المساهمون: Vincendeau, Estelle [0000-0002-0231-1609], Zhang, Xuefei [0000-0002-1873-6679], Yu, Wei [0000-0002-1777-5254], Cokelaer, Thomas [0000-0001-6286-1138], Adams, David J [0000-0001-9490-0306], Jackson, Stephen P [0000-0001-9317-7937], Balmus, Gabriel [0000-0003-2872-4468], Lescale, Chloé [0000-0003-0622-1149], Deriano, Ludovic [0000-0002-9673-9525], Apollo - University of Cambridge Repository, Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Howard Hughes Medical Institute (HHMI), Peking University [Beijing], Immunologie humorale - Humoral Immunology, Biomics (plateforme technologique), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, The Wellcome Trust Sanger Institute [Cambridge], University of Cambridge [UK] (CAM), The Deriano laboratory is funded by Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (Inserm), Wordwide Cancer Research (grant # 19-0333), Ligue Nationale Contre le Cancer (Equipe labellisée 2019), and Institut National du Cancer (INCa, grant # PLBIO19-122). E.V. is supported by the French Ministry of Higher Education, Research, and Innovation (Doctoral School Bio Sorbonne Paris Cité) and by the Fondation pour la Recherche Médicale. W.W. is part of the Pasteur–Paris University International Ph.D. program and received funding from the CNBG company, China. The Balmus laboratory at the UK DRI is funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. Research in the Jackson laboratory is funded by Cancer Research UK (CRUK) program grant DRCPGM\100005 and core grant C6946/A24843, Wellcome Investigator award 206388/Z/17/Z and core grant 203144, and ERC Synergy award 855741. S.P.J. receives a salary from the University of Cambridge. F.W.A is an investigator of the Howard Hughes Medical Institute. H.M. received core grants from the Institut Pasteur, the INSERM and the Milieu Intérieur Program (ANR-10-LABX-69-01)., We thank the Wellcome Trust Sanger Institute Mouse Genetics Project (Sanger MGP) and its funders for providing the mutant mouse line (Allele: Shld1em1(IMPC)Wtsi), and INFRAFRONTIER/EMMA. We thank the Institut Pasteur animal facility, specifically Quentin Mille, Jeromine Rohard Blanco, and Franck Bourgade for mouse weighing. We thank Jean-Pierre de Villartay for providing the CD21-Cre3a line and Klaus Rajewsky and MGC for permission to use the line. We thank Michela Di Virgilio for providing 53BP1 knockout animals and Junjie Chen for permission to use them. We thank members of the Deriano lab for their discussion and technical help. We thank Bernardo Reina-San-Martin for the discussion and advices. We thank Christopher Carnie for the discussion on the design of SHLD1 mutant sites., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Jackson, Stephen [0000-0001-9317-7937]

المصدر: Nature Communications
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩

مصطلحات موضوعية: DNA End-Joining Repair, MESH: V(D)J Recombination, [SDV]Life Sciences [q-bio], MESH: DNA Breaks, Double-Stranded, General Physics and Astronomy, 13/106, 45/23, 631/250/2152/2497, 631/250/2152/2498, General Biochemistry, Genetics and Molecular Biology, 13/1, 13/21, DNA Breaks, Double-Stranded, 631/337/1427/2122, Multidisciplinary, 45/71, 45, fungi, article, 45/77, General Chemistry, MESH: DNA End-Joining Repair, Immunoglobulin Class Switching, V(D)J Recombination, 49, DNA-Binding Proteins, 13/31, enzymes and coenzymes (carbohydrates), MESH: Immunoglobulin Class Switching, 631/337/149, MESH: DNA-Binding Proteins

وصف الملف: application/pdf; application/zip; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552ddce6e8fcc03619460c08b3e7d7aTest

المؤلفون: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy, Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic

المساهمون: Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur Paris (IP), Cellule Pasteur, Université Paris Diderot - Paris 7 (UPD7)-PRES Sorbonne Paris Cité, This work was supported by the Institut Pasteur, the European Research Council under the ERC starting grant agreement # 310917 and the Institut National du Cancer (# PLBIO16-181). J.J.B. is a BioSPC/Université Paris 5 doctoral Fellow., We thank Bernardo Reina San Martin, Erika Brunet and Jean-Pierre de Villartay for initial discussion and reagents and the Institut Pasteur Cytometry Platform and Center for Human Immunology for their help., European Project: 310917,EC:FP7:ERC,ERC-2012-StG_20111109,LYMPHOONCOGENOMICS(2013)

المصدر: ISSN: 0022-1759 ; Journal of Immunological Methods ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165Test ; Journal of Immunological Methods, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩.

مصطلحات موضوعية: CRISPR/Cas9-mediated gene knock-out, Nonhomologous end joining (NHEJ), Recombination-activating gene (RAG) endonuclease, V(D)J recombination, v-Abl transformed pro-B cells, MESH: Animals, MESH: Apoptosis, MESH: Protein Kinase Inhibitors, MESH: Proto-Oncogene Proteins c-bcl-2, MESH: CRISPR-Associated Proteins, MESH: Recombinational DNA Repair, MESH: CRISPR-Cas Systems, MESH: Cell Line, Transformed, MESH: Clustered Regularly Interspaced Short Palindromic Repeats, MESH: DNA Breaks, Double-Stranded, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins, MESH: Gene Editing, MESH: G1 Phase Cell Cycle Checkpoints, MESH: Genotype, MESH: Homeodomain Proteins, MESH: Imatinib Mesylate, MESH: Mice, Inbred C57BL, MESH: Oncogene Proteins v-abl, MESH: Phenotype, MESH: Precursor Cells, B-Lymphoid

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28882611; info:eu-repo/grantAgreement/EC/FP7/310917/EU/Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers/LYMPHOONCOGENOMICS; pasteur-03271165; https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165Test; https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/documentTest; https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/file/1-s2.0-S0022175917303447-main.pdfTest; PUBMED: 28882611; PUBMEDCENTRAL: PMC5714433

الإتاحة: https://doi.org/10.1016/j.jim.2017.08.007Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/documentTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/file/1-s2.0-S0022175917303447-main.pdfTest

المؤلفون: Gigi, Vered, Lewis, Susanna, Shestova, Olga, Mijušković, Martina, Deriano, Ludovic, Meng, Wenzhao, Luning Prak, Eline T, Roth, David B

المساهمون: University of Pennsylvania, Développement lymphocytaire et Oncogénèse, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health CA-104588 to D.B.R., 1R21AI097825-01 to S.M.L. .

المصدر: ISSN: 0305-1048.

مصطلحات موضوعية: DNA Breaks, Double-Stranded, DNA End-Joining Repair, Animals, Antigens, Nuclear/genetics, DNA-Binding Proteins/*genetics, Genes, p53, Ku Autoantigen, Lymphoma/genetics, Mice, Knockout, Receptors, Antigen, T-Cell/genetics, Sequence Deletion, Translocation, Genetic, V(D)J Recombination, MESH: Animals, MESH: Antigens, Nuclear, MESH: Receptors, T-Cell, MESH: Sequence Deletion, MESH: Translocation, MESH: V(D)J Recombination, MESH: DNA Breaks, MESH: DNA End-Joining Repair

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24753404; pasteur-01471690; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690Test; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/documentTest; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/file/gku295.pdfTest; PUBMED: 24753404; PUBMEDCENTRAL: PMC4041462

الإتاحة: https://doi.org/10.1093/nar/gku295Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/documentTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/file/gku295.pdfTest

المؤلفون: Loelia Babin, Caroline Demangel, Hélène Lenden-Hasse, Ludovic Deriano, Ludivine Baron, Erika Brunet, José Yélamos, Marie Bedora-Faure, Wei Yu, Chloé Lescale

المساهمون: Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris], Genome dynamics in the immune system (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, This project is funded by the Institut Pasteur (L.D. and C.D. labs), the Institut National du Cancer (INCa Grant # PLBIO16-181 to L.D. and E.B. labs), the Ligue Nationale Contre le Cancer (Équipe Labellisée 2019 L.D. lab and Équipe Labellisée 2017 and 2020 E.B. lab) the Cancéropôle IdF-INCa (Emergence 2016 grant to L.D. and C.D.), the Spanish Ministerio de Economía, Industria y Competitividad (Grant SAF2017-83565-R to J.Y.) as well as by the Fundación Científica de la Asociación Española Contra el Cáncer (AECC) (Grant PROYEI6018YÉLA to J.Y.)., We thank the Institut Pasteur genomics and cytometry platforms for help with sequencing and cell sorting, Frederick Alt and members of his lab for tremendous help with LAM-HTGTS experiments, Barry Sleckman for providing the RAG2-Thy1.1 complementation vector, Joy Bianchi for providing the Rag2−/− p53−/− v-Abl pro-B cell lines, Carine Giovannangeli and Anne de Cian for providing the Cas9 protein and Thomas Mercher for helpful discussions and suggestions., Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Demangel, Caroline, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5239. ⟨10.1038/s41467-020-19060-w⟩
Nature Communications, 2020, 11 (1), pp.5239. ⟨10.1038/s41467-020-19060-w⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, DNA End-Joining Repair, MESH: DNA Breaks, Double-Stranded, Poly (ADP-Ribose) Polymerase-1, General Physics and Astronomy, MESH: Cell Cycle, MESH: Poly (ADP-Ribose) Polymerase-1, Genome, Càncer--Tractament, chemistry.chemical_compound, Mice, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, DNA Breaks, Double-Stranded, MESH: Animals, lcsh:Science, Double strand, Multidisciplinary, Cell Cycle, DNA repair protein XRCC4, Cell cycle, 3. Good health, Cell biology, DNA-Binding Proteins, 030220 oncology & carcinogenesis, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cell division, DNA repair, ADN--Dany, DNA recombination, Science, Double-strand DNA breaks, MESH: G1 Phase, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Targeted therapies, Animals, MESH: Mice, B cells, fungi, G1 Phase, General Chemistry, MESH: DNA End-Joining Repair, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, lcsh:Q, Homologous recombination, DNA, MESH: DNA-Binding Proteins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3732515aa216a36cf4ec687e59a5511bTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-03262335/documentTest

المؤلفون: Deriano, Ludovic, Roth, David B

المساهمون: Développement lymphocytaire et Oncogénèse, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), University of Pennsylvania

المصدر: ISSN: 0066-4197.

مصطلحات موضوعية: Immunoglobulin Class Switching/genetics, Homologous Recombination/genetics, Animals, Ataxia Telangiectasia Mutated Proteins/genetics/physiology, Cell Death, Cell Transformation, Neoplastic, DNA-Activated Protein Kinase/physiology, DNA Breaks, Double-Stranded, DNA End-Joining Repair/*genetics, Gene Rearrangement, Genetic Therapy, Genomic Instability, Models, Genetic, Mutagenesis, VDJ Recombinases/physiology, V(D)J Recombination, MESH: Animals, MESH: Ataxia Telangiectasia Mutated Proteins, MESH: DNA Breaks, MESH: DNA End-Joining Repair, MESH: DNA-Activated Protein Kinase, MESH: Gene Rearrangement, MESH: Genetic Therapy, MESH: Genomic Instability, MESH: Homologous Recombination, MESH: Immunoglobulin Class Switching, MESH: Models

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24050180; pasteur-01471700; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700Test; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700/documentTest; https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700/file/annurev-genet-110711-155540%20-%20copie.pdfTest; PUBMED: 24050180

الإتاحة: https://doi.org/10.1146/annurev-genet-110711-155540Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700/documentTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471700/file/annurev-genet-110711-155540%20-%20copie.pdfTest

المؤلفون: Wilhelm Vaysse-Zinkhöfer, David Viterbo, Stéphane Descorps-Declère, Lucie Poggi, Guy-Franck Richard, Valentine Mosbach

المساهمون: Génétique des génomes - Genetics of Genomes (UMR 3525), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Collège Doctoral, Sorbonne Université (SU), V. M. was supported by Fondation Guy Nicolas and Fondation Hardy. W. V.-Z. is the recipient of a PhD fellowship from la Ligue Nationale Contre le Cancer. This work was generously supported by the Institut Pasteur and by the Centre National de la Recherche Scientifique (CNRS).

المصدر: PLoS Genetics, Vol 16, Iss 7, p e1008924 (2020)
PLoS Genetics
PLoS Genetics, 2020, 16 (7), pp.e1008924. ⟨10.1371/journal.pgen.1008924⟩

مصطلحات موضوعية: Cancer Research, MESH: CRISPR-Cas Systems, DNA End-Joining Repair, DNA Repair, [SDV]Life Sciences [q-bio], RAD52, MESH: DNA Breaks, Double-Stranded, Yeast and Fungal Models, MESH: CRISPR-Associated Protein 9, QH426-470, Biochemistry, Genome, Electrophoretic Blotting, DNA Ligase ATP, Guide RNA, MESH: Saccharomyces cerevisiae Proteins, Trinucleotide Repeats, CRISPR-Associated Protein 9, MESH: Endonucleases, MESH: Gene Conversion, MESH: Trinucleotide Repeat Expansion, Myotonic Dystrophy, DNA Breaks, Double-Stranded, Genetics (clinical), Gel Electrophoresis, Recombination, Genetic, Genetics, MESH: DNA Repair, Fungal genetics, Eukaryota, MESH: Saccharomyces cerevisiae, MESH: Chromosomes, Fungal, DNA-Binding Proteins, Nucleic acids, Experimental Organism Systems, Saccharomyces Cerevisiae, MESH: Recombination, Genetic, Chromosome Deletion, Chromosomes, Fungal, Research Article, MESH: Trinucleotide Repeats, Saccharomyces cerevisiae Proteins, MESH: Myotonic Dystrophy, MESH: Chromosome Deletion, Gene Conversion, Molecular Probe Techniques, Biology, Research and Analysis Methods, Myotonic dystrophy, MESH: Rad52 DNA Repair and Recombination Protein, Saccharomyces, Electrophoretic Techniques, Model Organisms, MESH: DNA Ligase ATP, medicine, Humans, Gene conversion, Molecular Biology Techniques, Molecular Biology, Ecology, Evolution, Behavior and Systematics, MESH: Genome, Human, MESH: Humans, Biology and life sciences, Genome, Human, Organisms, Fungi, DNA, MESH: DNA End-Joining Repair, Endonucleases, medicine.disease, Yeast, Rad52 DNA Repair and Recombination Protein, Genetic Loci, Rad50, Mutation, Animal Studies, RNA, Human genome, CRISPR-Cas Systems, Trinucleotide Repeat Expansion, Trinucleotide repeat expansion, Southern Blot, MESH: DNA-Binding Proteins, Cloning

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af72aaff1c19e94d418813f2ccf2888eTest
https://doaj.org/article/4d98239c049246cda0811bc9d615a42eTest