يعرض 1 - 10 نتائج من 42 نتيجة بحث عن '"MESH: Breast Neoplasms / genetics"', وقت الاستعلام: 1.23s تنقيح النتائج
  1. 1
    دورية أكاديمية

    المؤلفون: Ferreira, Manuel, Gamazon, Eric, Al-Ejeh, Fares, Aittomäki, Kristiina, Andrulis, Irene, Anton-Culver, Hoda, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan, Arun, Banu, Asseryanis, Ella, Azzollini, Jacopo, Balmaña, Judith, Barnes, Daniel, Barrowdale, Daniel, Beckmann, Matthias, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia, Bojesen, Stig, Bolla, Manjeet, Borg, Åke, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Caldés, Trinidad, Caligo, Maria, Adelaide, Campa, Daniele, Campbell, Ian, Canzian, Federico, Carter, Jonathan, Carter, Brian, Castelao, Jose, Chang-Claude, Jenny, Chanock, Stephen, Christiansen, Hans, Chung, Wendy, Claes, Kathleen, Clarke, Christine, Couch, Fergus, Cox, Angela, Cross, Simon, S., Czene, Kamila, Daly, Mary, B., de La Hoya, Miguel, Dennis, Joe, Devilee, Peter, Diez, Orland, Dörk, Thilo, Dunning, Alison, Dwek, Miriam, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter, Fletcher, Olivia, Flyger, Henrik, Friedman, Eitan, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Ganz, Patricia, Gapstur, Susan, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José, Gaudet, Mia, Giles, Graham, G, Glendon, Gord, Godwin, Andrew, Goldberg, Mark, S., Goldgar, David, E., González-Neira, Anna, Greene, Mark, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher, Hall, Per, Hamann, Ute, He, Wei, Heyworth, Jane, Hogervorst, Frans, Hollestelle, Antoinette, Hoover, Robert, Hopper, John, Hulick, Peter, Humphreys, Keith, Imyanitov, Evgeny, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jankowitz, Rachel, John, Esther, M., Johnson, Nichola, Joseph, Vijai, Karlan, Beth, Khusnutdinova, Elza, K., Kiiski, Johanna, Ko, Yon-Dschun, Jones, Michael, Konstantopoulou, Irene, Kristensen, Vessela, Laitman, Yael, Lambrechts, Diether, Lázaro, Conxi, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindström, Sara, Long, Jirong, Loud, Jennifer, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Maurer, Tabea, Mavroudis, Dimitrios, Mcguffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna Marie, Nathanson, Katherine, Neuhausen, Susan, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn, Nikitina-Zake, Liene, Nussbaum, Robert, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael, Pedersen, Inge Søkilde, Peixoto, Ana, Peterlongo, Paolo, Pharoah, Paul, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Presneau, Nadege, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey, Saloustros, Emmanouil, Sanden, Kristin, Sawyer, Elinor, Schmidt, Marjanka, Schmutzler, Rita, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian, Soucy, Penny, Southey, Melissa, Spinelli, John, Spurdle, Amanda, Stone, Jennifer, Swerdlow, Anthony, Tapper, William, Taylor, Jack, Teixeira, Manuel, R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy, Tischkowitz, Marc, Toland, Amanda, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine, van Asperen, Christi, van den Ouweland, Ans, van Rensburg, Elizabeth, Jansen, Vega, Ana, Viel, Alessandra, Wang, Qin, Wappenschmidt, Barbara, Weitzel, Jeffrey, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong, Yannoukakos, Drakoulis, Ziogas, Argyrios, Kraft, Peter, Antoniou, Antonis, C., Zheng, Wei, Easton, Douglas, F., Milne, Roger, L, Beesley, Jonathan, Chenevix-Trench, Georgia, Pujol, Pascal

    المساهمون: QIMR Berghofer Medical Research Institute, Vanderbilt University School of Medicine Nashville, University of Cambridge UK (CAM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Toronto, University of California Irvine (UC Irvine), University of California (UC), Reykjavík University, German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Queen's University Kingston, Canada, The University of Texas M.D. Anderson Cancer Center Houston, Medizinische Universität Wien = Medical University of Vienna, Università degli Studi di Milano = University of Milan (UNIMI), Vall d'Hebron Institute of Oncology Barcelone (VHIO), Vall d'Hebron University Hospital Barcelona, Centre for Cancer Genetic Epidemiology Cambridge, University of Cambridge UK (CAM)-Department of Oncology, Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg (FAU), CIBER de Enfermedades Raras (CIBERER), Spanish National Cancer Research Center (CNIO), Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences Moscow (RAS), West Pomeranian University of Technology Szczecin, Örebro University Hospital Örebro, Sweden, Department of Obstetrics and Gynaecology (MHH), Medizinische Hochschule Hannover = Hannover Medical School (MHH), Institute of Biophysics and Cell Engineering, NASB, Minsk, National Academy of Sciences of Belarus (NASB), University of Copenhagen = Københavns Universitet (UCPH), Cancer Research UK Cambridge Institute Cambridge, Royaume-Uni (CRUK), Skane University Hospital Lund, Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology Stuttgart, Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Molecular Epidemiology Research Group, University Medical Center Heidelberg, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos Madrid, Spain (IdISSC), University of Pisa - Università di Pisa, Peter MacCallum Cancer Center, The University of Sydney, American Cancer Society Atlanta, GA, USA, Instituto de Investigación Sanitaria Galicia Sur Vigo, Spain, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf Hamburg (UKE), National Cancer Institute Bethesda (NCI-NIH), National Institutes of Health Bethesda, MD, USA (NIH), Columbia University New York, Ghent University Hospital, The Westmead Institute for Medical Research, Dpt of Oncology Rochester, Mayo Clinic, University of Sheffield Sheffield, Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet Stockholm, Fox Chase Cancer Center, Leiden University Medical Center (LUMC), Universiteit Leiden = Leiden University, University of Westminster London (UOW), Rigshospitalet Copenhagen, Copenhagen University Hospital, Department of Oncology and Pathology Lund, Institute for Medical Informatics, Statistics and Epidemiology Leipzig (IMISE), Leipzig University / Universität Leipzig, Cancer Center Karolinska Karolinska Institutet (CCK), David Geffen School of Medicine Los Angeles, University of California Los Angeles (UCLA), University of California (UC)-University of California (UC), The institute of cancer research London, City University of New York New York (CUNY), The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Universidade de Santiago de Compostela Spain (USC ), Dana-Farber Cancer Institute Boston, University of Melbourne, University of Kansas Medical Center Kansas City, KS, USA, McGill University = Université McGill Montréal, Canada, Huntsman Cancer Institute Salt Lake City, University of Utah, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern California (USC), The University of Western Australia (UWA), Erasmus University Medical Center Rotterdam (Erasmus MC), Columbia University Medical Center (CUMC), Melbourne Medical School Melbourne, Faculty of Medicine, Dentistry and Health Sciences Melbourne

    المصدر: ISSN: 2041-1723.

  2. 2
    دورية أكاديمية

    المساهمون: Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ), The University of Sydney, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut Curie Paris, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Department of Biochemistry University of Toronto, University of Toronto, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), This work was supported by the National Center for Scientific Research (CNRS) to EB, the National Institute of Health and Medical Research (INSERM), the University of Lyon1, La Ligue Nationale (Drôme), Inserm-Transfert (EB). GV was supported by the Labex DEVweCAN, MG, MB by the French National Cancer Institute (INCa), CK by the Marie-Curie-Individual-Fellowship (655777-miR-OMeS). CAP, LC, and MM by CANCER-ID (FP7/2007-2013) and EFPIA., The authors thank Anne Flourens, Cyprien Tilmant, Tina Louadj, and both CeCIL and ALECS platforms (Faculté de Médecine Laennec, Lyon) for their assistance., ANR-10-LABX-0061,DEVWECAN,Development Cancer and Targeted Therapies(2010)

    المصدر: ISSN: 0950-9232.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30478447; hal-02353108; https://hal.science/hal-02353108Test; https://hal.science/hal-02353108/documentTest; https://hal.science/hal-02353108/file/Vargas%20et%20al-2019.pdfTest; PUBMED: 30478447

  3. 3
    دورية أكاديمية

    المساهمون: Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Universität Bonn = University of Bonn, This study was supported by CNRS, Association pour la Recherche contre le Cancer (ARC), Ligue Nationale contre le Cancer and Société Française du Cancer (SFC). AF was supported by Ministère de l’Education Nationale, Ligue Nationale contre le Cancer and Région Hauts de France (CPER Photonics 4 Society and 1-PRIMER)., The authors are particularly grateful to Dr Fabrice Soncin and all members of our laboratories for providing tools, helpful discussions and comments.

    المصدر: ISSN: 1019-6439.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30365153; hal-02413908; https://hal.science/hal-02413908Test; https://hal.science/hal-02413908/documentTest; https://hal.science/hal-02413908/file/ijo_54_1_29_PDF.pdfTest; PUBMED: 30365153; PUBMEDCENTRAL: PMC6254994

  4. 4
    دورية أكاديمية

    المساهمون: Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts Medical School Worcester (UMASS), University of Massachusetts System (UMASS), Institut Curie Paris, Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de Lille - UMS 3702 (IBL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Centre national de la recherche scientifique (CNRS), the Institut Pasteur de Lille, and Institut National de la Santé et de la Recherche Médicale (INSERM), as well as by grants from the Ligue contre le Cancer, comité Aisne and the Association pour la Recherche sur le Cancer., We thank Martine Duterque-Coquillaud, Anne Flourens, and Antonino Bongiovanni for their precious help in IHC experiments. We thank the Microscopy-Imaging-Cytometry Facility of the BioImaging Center Lille Nord-de-France for access to instruments and technical advice.

    المصدر: ISSN: 1465-5411.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29996935; hal-02391607; https://hal.science/hal-02391607Test; https://hal.science/hal-02391607/documentTest; https://hal.science/hal-02391607/file/ETV4_transcription_factor_and_MMP13_metalloprotease_are_interplaying.pdfTest; PUBMED: 29996935; PUBMEDCENTRAL: PMC6042225

  5. 5
    دورية أكاديمية

    المساهمون: Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Weill Cornell Medicine Qatar, Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM), Hôpital Charles Nicolle Tunis, Hôpital Abderrahmen Mami, Faculté des Sciences de Bizerte Université de Carthage, Université de Carthage (Tunisie) (UCAR), This work was supported by the “Qatar National Research Foundation” (NPRP 08–083–3-031) that contributed to the design of the study, collection, analysis, interpretation of data and in writing the manuscript., The authors would like to thank all the individuals who took part in this study and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out.

    المصدر: ISSN: 1471-2407.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30594178; pasteur-01984744; https://riip.hal.science/pasteur-01984744Test; https://riip.hal.science/pasteur-01984744/documentTest; https://riip.hal.science/pasteur-01984744/file/A%20genome.pdfTest; PUBMED: 30594178; PUBMEDCENTRAL: PMC6310952

  6. 6

    المساهمون: Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS], Institut de Génomique Fonctionnelle de Lyon [IGFL], Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB], The University of Sydney, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL], Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 [AIDMP], Institut Curie [Paris], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM], Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Institut de biologie de Lille - IBL [IBLI], Mécanismes de tumorigenèse et thérapies ciblées, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut Curie, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry [University of Toronto], University of Toronto, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, This work was supported by the National Center for Scientific Research (CNRS) to EB, the National Institute of Health and Medical Research (INSERM), the University of Lyon1, La Ligue Nationale (Drôme), Inserm-Transfert (EB). GV was supported by the Labex DEVweCAN, MG, MB by the French National Cancer Institute (INCa), CK by the Marie-Curie-Individual-Fellowship (655777-miR-OMeS). CAP, LC, and MM by CANCER-ID (FP7/2007-2013) and EFPIA., The authors thank Anne Flourens, Cyprien Tilmant, Tina Louadj, and both CeCIL and ALECS platforms (Faculté de Médecine Laennec, Lyon) for their assistance., Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie Générale et Médicale, INSERM-CNRS U.189 Faculté de Médecine Lyon-Sud, Centre de Recherche en Géomatique [Laval] (CRG), Université Laval, Swiss Federal Office for the Environment FOEN, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Génétique [Institut Curie, Paris] (Unité de Pharmacogénomique), Department of Surgery, Breast Health Center, Medical University Vienna, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie et chimie des protéines [Lyon] (IBCP), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Oncogene
    Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3 ⟩
    Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩
    Oncogene, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Breast Neoplasms/pathology, Bone Neoplasms/secondary, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Transcriptome, Mammary Neoplasms, Animal/genetics, Mice, 0302 clinical medicine, Circulating tumor cell, Neoplasm Proteins/genetics, MESH: Breast Neoplasms/genetics, MESH: Animals, MESH: Breast Neoplasms/metabolism, ComputingMilieux_MISCELLANEOUS, MESH: Breast Neoplasms/pathology, Mice, Inbred BALB C, Receptor Activator of Nuclear Factor-kappa B, Receptors, Estrogen/genetics, MESH: Receptor Activator of Nuclear Factor-kappa B/genetics, Metastatic breast cancer, Primary tumor, Neoplasm Proteins, 3. Good health, Gene Expression Regulation, Neoplastic, Receptors, Estrogen, RANKL, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Female, MESH: Bone Neoplasms/secondary, Breast Neoplasms/metabolism, MESH: Bone Neoplasms/genetics, Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Mice, Inbred BALB C, Bone Neoplasms, Breast Neoplasms, Mammary Neoplasms, Animal, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mammary Neoplasms, Animal/metabolism, Neoplasm Proteins/metabolism, Biology, Breast Neoplasms/genetics, 03 medical and health sciences, Breast cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, medicine, Animals, Humans, MESH: Neoplasm Proteins/genetics, MESH: Receptors, Estrogen/metabolism, MESH: Neoplasm Proteins/metabolism, MESH: Mammary Neoplasms, Animal/pathology, Mammary Neoplasms, Animal/pathology, Molecular Biology, MESH: Mice, PI3K/AKT/mTOR pathway, Receptor Activator of Nuclear Factor-kappa B/genetics, MESH: Humans, MESH: Receptors, Estrogen/genetics, Bone Neoplasms/genetics, medicine.disease, Receptors, Estrogen/metabolism, MESH: Mammary Neoplasms, Animal/genetics, 030104 developmental biology, Cancer cell, Bone Neoplasms/metabolism, Cancer research, biology.protein, MESH: Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Female, Bone Neoplasms/pathology, MESH: Mammary Neoplasms, Animal/metabolism, MESH: Bone Neoplasms/pathology

    وصف الملف: application/octet-stream; application/pdf

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    المساهمون: Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Weill Cornell Medicine [Qatar], Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM), Hôpital Charles Nicolle [Tunis], Hôpital Abderrahmen Mami, Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage, This work was supported by the 'Qatar National Research Foundation' (NPRP 08–083–3-031) that contributed to the design of the study, collection, analysis, interpretation of data and in writing the manuscript., The authors would like to thank all the individuals who took part in this study and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out.

    المصدر: BMC Cancer
    BMC Cancer, BioMed Central, 2018, 18 (1), pp.1295. ⟨10.1186/s12885-018-5133-8⟩
    BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)

  8. 8

    المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)

    المصدر: Nature Cell Biology
    Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
    Nature cell biology
    Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩

    مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins

    وصف الملف: application/pdf

  9. 9

    المساهمون: Université de Tunis El Manar (UTM), Departement Medecine Oncologique [Tunis], Institut Salah Azaiz [Tunis] (ISA), Departement Anatomopathologie [ISA, Tunis], Laboratoire de Parasitologie Médicale, Biotechnologies et Biomolécules (LR11IPT06), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST)

    المصدر: Immunologic Research
    Immunologic Research, Humana Press, 2016, ⟨10.1007/s12026-015-8782-6⟩
    Immunologic Research, Humana Press, 2016, 64 (4), pp.961-968. ⟨10.1007/s12026-015-8782-6⟩

  10. 10
    دورية أكاديمية

    المساهمون: Université de Tunis El Manar (UTM), Departement Medecine Oncologique Tunis, Institut Salah Azaiz Tunis (ISA), Departement Anatomopathologie ISA, Tunis, Laboratoire de Parasitologie Médicale, Biotechnologies et Biomolécules (LR11IPT06), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

    المصدر: ISSN: 0257-277X ; Immunologic Research ; https://riip.hal.science/pasteur-01400585Test ; Immunologic Research, 2016, 64 (4), pp.961-968. ⟨10.1007/s12026-015-8782-6⟩.