المؤلفون: Yamamoto N, Tolcher A, Hafez N, Lugowska I, Ramlau R, Macarulla T, Geng J, Li J, Teufel M, Märten A, LoRusso P

المصدر: OncoTargets and Therapy, Vol Volume 17, Pp 267-280 (2024)

مصطلحات موضوعية: biliary tract cancer • mdm2–p53 antagonist • brigimadlin • ezabenlimab • mdm2-amplified, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/efficacy-and-safety-of-the-mdm2p53-antagonist-brigimadlin-bi-907828-in-peer-reviewed-fulltext-article-OTTTest; https://doaj.org/toc/1178-6930Test

الوصول الحر: https://doaj.org/article/95442fd5c5ce42c0be632413044909c0Test

المؤلفون: Ali M. Alaseem

المصدر: Saudi Pharmaceutical Journal, Vol 31, Iss 10, Pp 101790- (2023)

مصطلحات موضوعية: MDM2, Combination therapy, Resistance, Efficacy, MDM2-p53 axis, Cancer treatment, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1319016423002852Test; https://doaj.org/toc/1319-0164Test

الوصول الحر: https://doaj.org/article/611d2a76428c451baf8d479fd739300aTest

المؤلفون: Tagyedeen H. Shoaib, Nihal Abdelmoniem, Rua M. Mukhtar, Amal Th. Alqhtani, Abdullah L. Alalawi, Razan Alawaji, Mashael S. Althubyani, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Hazem G. A. Hussein, Abdulrahim A. Alzain

المصدر: Molecules, Vol 28, Iss 18, p 6665 (2023)

مصطلحات موضوعية: cancer, MDM2-P53, PPI, Ferula sinkiangensis, Justicia procumbens, lignans, Organic chemistry, QD241-441

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1420-3049/28/18/6665Test; https://doaj.org/toc/1420-3049Test

الوصول الحر: https://doaj.org/article/847abb685e4c43d3943f8c02d23214ecTest

المؤلفون: Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 2410

مصطلحات موضوعية: p53 pathway, splicing modulation, MDM2–p53 antagonists, RG7388 (idasanutlin), E7107

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Oncology; https://dx.doi.org/10.3390/ijms24032410Test

الإتاحة: https://doi.org/10.3390/ijms24032410Test

المؤلفون: Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11335 (2023)

مصطلحات موضوعية: SF3B1, splicing factor, MDM2-p53 antagonists, RG7388 (idasanutlin), chronic lymphocytic leukemia (CLL), Biology (General), QH301-705.5, Chemistry, QD1-999

العلاقة: https://www.mdpi.com/1422-0067/24/14/11335Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072Test

الإتاحة: https://doi.org/10.3390/ijms241411335Test
https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072Test

المؤلفون: Sun C, Li M, Feng Y, Sun F, Zhang L, Xu Y, Lu S, Zhu J, Huang J, Wang J, Hu Y, Zhang Y

المصدر: OncoTargets and Therapy, Vol Volume 13, Pp 10475-10487 (2020)

مصطلحات موضوعية: dlbcl, mdm2-p53 signaling pathway, cdc20, tumor progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://www.dovepress.comTest/mdm2-p53-signaling-pathway-mediated-upregulation-of-cdc20-promotes-pro-peer-reviewed-article-OTT; https://doaj.org/toc/1178-6930Test

الوصول الحر: https://doaj.org/article/033c2ead6cf24830a37963aa6a5fce9dTest

المؤلفون: Lotfy, Gehad, Abdel Aziz, Yasmine M., Said, Mohamed M., El Ashry, El Sayed H., El Tamany, El Sayed H., Abu-Serie, Marwa M., Teleb, Mohamed, Dömling, Alexander, Barakat, Assem

المصدر: Lotfy , G , Abdel Aziz , Y M , Said , M M , El Ashry , E S H , El Tamany , E S H , Abu-Serie , M M , Teleb , M , Dömling , A & Barakat , A 2021 , ' Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation : A step towards the next generation p53 activators ' , Bioorganic Chemistry , vol. 117 , 105427 . https://doi.org/10.1016/j.bioorg.2021.105427Test

مصطلحات موضوعية: BCL2, MDM2 inhibitors, MDM2-p53 interaction, Spirooxindole, [3+2] cycloaddition reaction (32CA)

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/f4d50d5d-0a3d-4abe-8c95-1f91ef63ddc2Test

الإتاحة: https://doi.org/10.1016/j.bioorg.2021.105427Test
https://hdl.handle.net/11370/f4d50d5d-0a3d-4abe-8c95-1f91ef63ddc2Test
https://research.rug.nl/en/publications/f4d50d5d-0a3d-4abe-8c95-1f91ef63ddc2Test
https://pure.rug.nl/ws/files/205038649/fmolb_08_727144.pdfTest
http://www.scopus.com/inward/record.url?scp=85117506484&partnerID=8YFLogxKTest

المؤلفون: Pankaj Attri, Hirofumi Kurita, Kazunori Koga, Masaharu Shiratani

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 17; Pages: 9585

مصطلحات موضوعية: Mdm2–p53, plasma treatment, molecular dynamic (MD) simulations

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Biophysics; https://dx.doi.org/10.3390/ijms22179585Test

الإتاحة: https://doi.org/10.3390/ijms22179585Test

المؤلفون: B Vijay Raj, M V Raghavendra Rao, Yogesh Acharya

المصدر: Acta Medica International, Vol 4, Iss 1, Pp 11-21 (2017)

مصطلحات موضوعية: Docking, Molecular dynamic simulation, MDM2-P53 interaction, Nutlin, Virtual screening ZINC59256947, Medicine

وصف الملف: electronic resource

العلاقة: http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2017;volume=4;issue=1;spage=11;epage=21;aulast=RajTest; https://doaj.org/toc/2349-0578Test; https://doaj.org/toc/2349-0896Test

الوصول الحر: https://doaj.org/article/ac6df3e843bb4bea9223fc9214bf49cfTest

المؤلفون: Yasmina M. Abd-Elhakim, Mohamed Abdo Nassan, Gamal A. Salem, Abdelkarim Sasi, Adil Aldhahrani, Khaled Ben Issa, Amany Abdel-Rahman Mohamed

المصدر: Toxins; Volume 11; Issue 11; Pages: 642

مصطلحات موضوعية: Euphorbia peplus, MDM2-p53, apoptosis, anticancer, di-(2-ethylhexyl) phthalate

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Plant Toxins; https://dx.doi.org/10.3390/toxins11110642Test

الإتاحة: https://doi.org/10.3390/toxins11110642Test