المؤلفون: Clemente, Claudia, Johnson, Nicholas, Ouyang, Xiaodan, Popin, Rafael, Dall'Angelo, Sergio, Wahlsten, Matti, Jokela, Jouni, Colombano, Alessandro, Nardone, Brunello, Fewer, David P., Houssen, Wael E.

المساهمون: Institute of Biotechnology, Department of Food and Nutrition, Department of Microbiology, Faculty of Agriculture and Forestry, Cyanobacteria research, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products

مصطلحات موضوعية: DRUG DISCOVERY, CYCLIC PEPTIDE, MACROCYCLASE, HETEROCYCLIZATION, TRYPTOPHAN, PROTEINS, ENZYMES, ENABLES, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: This project was supported by a fellowship grant from the EPSRC (No. EP/S027246/1, W.E.H.), a training grant from the BBSRC (BB/V509206/1, W. E. H. and S. D.), the Novo Nordisk Foundation (18OC0034838, D. P. F.) and the NordForsk NCoE program ``NordAqua'' (Project Number 82845, D. P. F.). C. C. is funded by a PhD studentship from University of Aberdeen. N. J. is funded by the IBioIC CTP PhD programme. R. V. P. was funded by the Doctoral Programme in Microbiology and Biotechnology of the University of Helsinki. X. O. was funded by the China Scholarship Council (Grant 201906150148). We are grateful to Professor James Naismith (University of Oxford) for sharing the construct used to express the macrocyclase PCY1. We thank Dr Huanting Liu (University of St Andrews) for sharing the pEHISTEV-SUMO vector.; Clemente , C , Johnson , N , Ouyang , X , Popin , R , Dall'Angelo , S , Wahlsten , M , Jokela , J , Colombano , A , Nardone , B , Fewer , D P & Houssen , W E 2022 , ' Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway ' , Chemical Communications , vol. 58 , no. 86 , pp. 12054-12057 . https://doi.org/10.1039/d2cc01799gTest; ORCID: /0000-0003-3978-4845/work/123135547; ORCID: /0000-0001-5096-3575/work/123136680; ORCID: /0000-0002-4107-1695/work/123138419; ORCID: /0000-0003-0427-0326/work/123143232; http://hdl.handle.net/10138/350678Test; 3b58f94b-ecb7-4af4-af19-d4b0750e3f24; 000863636300001

الإتاحة: http://hdl.handle.net/10138/350678Test

المؤلفون: Krishna P. Patel (11138487), Lily M. Silsby (11138490), Gengnan Li (1590955), Steven D. Bruner (1576660)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, serine protease inhibitors, ATP-grasp ligases, substrate peptide, macrocyclase, Chemoenzymatic Synthesis, Peptide Macrocyclases, microviridin biosynthesis, strategy, leader portion, core peptides, cyanobacterial tricyclic depsipeptides, function, ring architectures, interaction, structure-based design, constitutively, Microviridins Microviridins, biosynthetic enzymes, Structure-Based Engineering

العلاقة: https://figshare.com/articles/journal_contribution/Structure-Based_Engineering_of_Peptide_Macrocyclases_for_the_Chemoenzymatic_Synthesis_of_Microviridins/14987481Test

الإتاحة: https://doi.org/10.1021/acs.joc.1c00785.s001Test

المؤلفون: Muhammad, Taj, 1982

المساهمون: Göransson, Ulf, Professor, 1970, Gunasekera, Sunithi, Researcher, 1977, Strömstedt, Adam A., Researcher, 1977, Guangshun, Wang, Associate Professor

المصدر: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy.

مصطلحات موضوعية: antimicrobial peptide, host defense, antimicrobial, LL-37, KR-12, peptide cyclisation, peptide dimerisation, croos-linking, cyanobactin-macrocyclase, PatGmac, butelase 1, enzymatic cyclisation, immobilisation, Farmakognosi, Pharmacognosy

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397191Test
https://uu.diva-portal.org/smash/get/diva2:1370812/FULLTEXT01.pdfTest
https://uu.diva-portal.org/smash/get/diva2:1370812/PREVIEW01.jpgTest

المؤلفون: Claudia Clemente, Nicholas Johnson, Xiaodan Ouyang, Rafael V. Popin, Sergio Dall'Angelo, Matti Wahlsten, Jouni Jokela, Alessandro Colombano, Brunello Nardone, David P. Fewer, Wael E. Houssen

المساهمون: Institute of Biotechnology, Department of Food and Nutrition, Department of Microbiology, Faculty of Agriculture and Forestry, Cyanobacteria research, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products

المصدر: Chemical Communications. 58:12054-12057

مصطلحات موضوعية: HETEROCYCLIZATION, PROTEINS, Metals and Alloys, ENABLES, General Chemistry, Catalysis, TRYPTOPHAN, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, DRUG DISCOVERY, Materials Chemistry, Ceramics and Composites, 1182 Biochemistry, cell and molecular biology, MACROCYCLASE, ENZYMES, CYCLIC PEPTIDE

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cf0027e504cdb09e4dc67db5b6a775Test
https://doi.org/10.1039/d2cc01799gTest

المؤلفون: Czekster, Clarissa, Ludewig, Hannes, McMahon, Stephen A., Naismith, James H.

المصدر: Enzyme Engineering XXIV

مصطلحات موضوعية: macrocycle, macrocyclase, peptide, natural product, prolyl oligopeptidase, Engineering

العلاقة: https://dc.engconfintl.org/enzyme_xxiv/115Test

الإتاحة: https://dc.engconfintl.org/enzyme_xxiv/115Test

مصطلحات الفهرس: antimicrobial peptide, host defense, antimicrobial, LL-37, KR-12, peptide cyclisation, peptide dimerisation, croos-linking, cyanobactin-macrocyclase, PatGmac, butelase 1, enzymatic cyclisation, immobilisation, Medical and Health Sciences, Medicin och hälsovetenskap, Doctoral thesis, comprehensive summary, info:eu-repo/semantics/doctoralThesis, text

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397191Test
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 1651-6192 ; 281

مصطلحات الفهرس: antimicrobial peptide, host defense, antimicrobial, LL-37, KR-12, peptide cyclisation, peptide dimerisation, croos-linking, cyanobactin-macrocyclase, PatGmac, butelase 1, enzymatic cyclisation, immobilisation, Medical and Health Sciences, Medicin och hälsovetenskap, Doctoral thesis, comprehensive summary, info:eu-repo/semantics/doctoralThesis, text

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397191Test
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 1651-6192 ; 281