دورية أكاديمية
Thrombotic Occlusion in Patients With Acute Ischemic Stroke ; Тромботическая окклюзия у пациентов с острым ишемическим инсультом
| العنوان: | Thrombotic Occlusion in Patients With Acute Ischemic Stroke ; Тромботическая окклюзия у пациентов с острым ишемическим инсультом |
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| المؤلفون: | E. Kovaleva A., G. Ramazanov R., L. Kokov S., R. Muslimov Sh., M. Parkhomenko V., V. Stepanov N., E. Bardina M., K. Pushkareva R., M. Solovtsova S., A. Sherstyanikh O., A. Izmailova M., Э. Ковалева А., Г. Рамазанов Р., Л. Коков С., Р. Муслимов Ш., М. Пархоменко В., В. Степанов Н., Е. Бардина М., К. Пушкарева Р., М. Соловцова С., А. Шерстяных О., А. Измайлова М. |
| المصدر: | Russian Sklifosovsky Journal "Emergency Medical Care"; Том 10, № 4 (2021); 659-668 ; Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»; Том 10, № 4 (2021); 659-668 ; 2541-8017 ; 2223-9022 |
| بيانات النشر: | “N.V. Sklifosovsky Research Institute for Emergency Medicine” |
| سنة النشر: | 2022 |
| المجموعة: | Sklifosovsky Journal "Emergency Medical Care" / Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь» |
| مصطلحات موضوعية: | ischemic stroke, reperfusion therapy, cerebral artery thrombosis, cryptogenic stroke, ишемический инсульт, реперфузионная терапия, тромбоз мозговой артерии, криптогенный инсульт |
| الوصف: | Currently, reperfusion therapy is the main method of treating patients with ischemic stroke (IS). The safety and efficacy of systemic thrombolytic therapy with a recombinant tissue plasminogen activator in patients with IS within 3 hours, and then 4.5 hours after the onset of symptoms of the disease was demonstrated in the NINDS (1995) and ECASS III (2008) studies. In 2018, based on the results of five studies, clear indications were formulated for performing thrombectomy (TE) in patients with IS, which involve the detection of thrombosis of a large stroke-associated artery. Given the continuous growth in the number of the adult population, which constitutes the bulk of patients with IS, information on the prevalence of patients with thrombotic occlusion of cerebral arteries, who are potential candidates for TE, may be important for regional vascular centers.Aim of study. To describe IS patients admitted within the 6-hour “therapeutic window”.Materials and methods. The study included 145 patients with cerebral IS who were admitted within the first 6 hours after the onset of symptoms of the disease. All patients underwent computed tomographic (CT) angiography in order to verify the occlusion of the cerebral artery.Results. In our study, a correlation was established between the NIHSS severity of IS and the likelihood of verification of stroke-related artery thrombosis by CT angiography, but in 32.6% of patients with severe stroke (NIHSS at least score 14), no thrombotic occlusion was detected, and in 13% of patients with a clinic of mild acute cerebrovascular accident (NIHSS no more than 6), on the contrary, thrombotic occlusion was detected. Mortality in patients with verified thrombotic occlusion of the cerebral artery was higher than in patients without it (38% versus 10.5%, p<0.001). Such a significant difference in the mortality rate was due to the initially more severe stroke (NIHSS at admission 17 [10; 23] versus 5 [2; 10], p><0.001) in patients with thrombotic occlusion of a stroke-related ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.23934/2223-9022-2021-10-4-659-668 |
| الإتاحة: | https://doi.org/10.23934/2223-9022-2021-10-4-659-668Test https://doi.org/10.1161/STR.0000000000000158Test https://doi.org/10.1056/NEJM199512143332401Test https://doi.org/10.1056/NEJMoa0804656Test https://doi.org/10.1056/NEJMoa1414905Test https://doi.org/10.1056/NEJMoa1414792Test https://doi.org/10.1056/NEJMoa1411587Test https://doi.org/10.1056/NEJMoa1212793Test https://doi.org/10.1056/NEJMoa1503780Test https://doi.org/10.1056/NEJMoa1415061Test |
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| رقم الانضمام: | edsbas.5D1BF7DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.23934/2223-9022-2021-10-4-659-668 |
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