دورية أكاديمية
Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
| العنوان: | Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases |
|---|---|
| المؤلفون: | Francisco J. Romero, Manuel Diaz-Llopis, M. Inmaculada Romero-Gomez, Maria Miranda, Rebeca Romero-Wenz, Javier Sancho-Pelluz, Belén Romero, Maria Muriach, Jorge M. Barcia |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 3, p 1618 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | exosomes, retinal diseases, oxidative stress, autophagy, microRNAs, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy. The fate of these vesicles is diverse: they could end up in circulation being used as markers, or target neighbor cells modulating gene and protein expression, or eventually, in angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, in the regulation of retinal angiogenesis is also discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/3/1618Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25031618 |
| الوصول الحر: | https://doaj.org/article/f0f8534a187541edb019cfed5af55340Test |
| رقم الانضمام: | edsdoj.f0f8534a187541edb019cfed5af55340 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms25031618 |