Protective role of thymoquinone against liver damage induced by tamoxifen in female rats
| العنوان: | Protective role of thymoquinone against liver damage induced by tamoxifen in female rats |
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| المؤلفون: | M SuddekGhada |
| المصدر: | Canadian Journal of Physiology and Pharmacology. 92:640-644 |
| بيانات النشر: | Canadian Science Publishing, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Antineoplastic Agents, Hormonal, Physiology, medicine.drug_class, Bilirubin, medicine.medical_treatment, Intraperitoneal injection, Protective Agents, Anti-inflammatory, Rats, Sprague-Dawley, chemistry.chemical_compound, Physiology (medical), Internal medicine, Lactate dehydrogenase, Benzoquinones, medicine, Animals, Nigella sativa, skin and connective tissue diseases, Thymoquinone, Pharmacology, business.industry, Estrogen Antagonists, General Medicine, Glutathione, Tamoxifen, Endocrinology, Liver, chemistry, Alkaline phosphatase, Female, Chemical and Drug Induced Liver Injury, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug |
| الوصف: | One of the major reasons for terminating a clinical trial is the liver toxicity induced by chemotherapy. Tamoxifen (TAM) is an anti-estrogen used in the treatment and prevention of hormone-dependent breast cancer. Tamoxifen therapy may cause hepatic injury. The seeds of Nigella sativa, which contain the active ingredient thymoquinone (TQ), have been used in folk medicine for diverse ailments. TQ is reported to possess anticancer and hepatoprotective effects. In this study, the protective effects of TQ against TAM-induced hepatotoxicity in female rats were evaluated. Four groups of rats were used: control; TAM; TQ; TAM+TQ. TAM (45 mg·(kg body mass)–1·day–1, by intraperitoneal injection (i.p.), for 10 consecutive days) resulted in elevated serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, and gamma glutamyl transferase, as well as depletion of reduced glutathione in the liver and accumulation of lipid peroxides. Also, TAM treatment inhibited the hepatic activity of superoxide dismutase. Further, it raised the levels of tumor necrosis factor alpha in the liver and induced histopathological changes. Pretreatment with TQ (50 mg·(kg body mass)–1·day–1; orally, for 20 consecutive days, starting 10 days before TAM injection) significantly prevented the elevation in serum activity of the assessed enzymes. TQ significantly inhibited TAM-induced hepatic GSH depletion and LPO accumulation. Consistently, TQ normalized the activity of SOD, inhibited the rise in TNF-α and ameliorated the histopathological changes. In conclusion, TQ protects against TAM-induced hepatotoxicity. |
| تدمد: | 1205-7541 0008-4212 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0fb107a252bd239096b35fea0ae386Test https://doi.org/10.1139/cjpp-2014-0148Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9d0fb107a252bd239096b35fea0ae386 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12057541 00084212 |
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