دورية أكاديمية

Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study

التفاصيل البيبلوغرافية
العنوان: Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study
المؤلفون: M.F. Nagoor Meeran, Sheikh Azimullah, M Marzouq Al Ahbabi, Niraj Kumar Jha, Vinoth-Kumar Lakshmanan, Sameer N. Goyal, Shreesh Ojha
المصدر: Molecules, Vol 25, Iss 23, p 5656 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Organic chemistry
مصطلحات موضوعية: nootkatone, sesquiterpene, bioactive agents, fragrant molecules, essential oils, natural products, Organic chemistry, QD241-441
الوصف: In the present study, we assessed whether nootkatone (NKT), a sesquiterpene in edible plants, can provide protection against dyslipidemia, intramyocardial lipid accumulation, and altered lipid metabolism in a rat model of myocardial infarction (MI) induced by subcutaneous injections of isoproterenol (ISO, 85 mg/kg) on days 9 and 10. The rats were pre- and co-treated with NKT (10 mg/kg, p.o.) administered daily for 11 days. A significant reduction in the activities of myocardial creatine kinase and lactate dehydrogenase, as well as non-enzymatic antioxidants, and alterations in lipids and lipoproteins, along with a rise in plasma lipid peroxidation and intramyocardial lipid accumulation, were observed in ISO-treated rats. ISO administration induced alterations in the activities of enzymes/expressions that played a significant role in altering lipid metabolism. However, NKT treatment favorably modulated all biochemical and molecular parameters altered by ISO and showed protective effects against oxidative stress, dyslipidemia, and altered lipid metabolism, attributed to its free-radical-scavenging and antihyperlipidemic activities in rats with ISO-induced MI. Additionally, NKT decreased the accumulation of lipids in the myocardium as evidenced from Oil red O staining. Furthermore, the in vitro observations demonstrate the potent antioxidant property of NKT. The present study findings are suggestive of the protective effects of NKT on dyslipidemia and the underlying mechanisms. Based on our findings, it can be suggested that NKT or plants rich in NKT can be promising for use as a phytopharmaceutical or nutraceutical in protecting the heart and correcting lipid abnormalities and dyslipidemia, which are risk factors for ischemic heart diseases.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 25235656
1420-3049
العلاقة: https://www.mdpi.com/1420-3049/25/23/5656Test; https://doaj.org/toc/1420-3049Test
DOI: 10.3390/molecules25235656
الوصول الحر: https://doaj.org/article/fea0e56ca29e4446a99080007b361de0Test
رقم الانضمام: edsdoj.fea0e56ca29e4446a99080007b361de0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25235656
14203049
DOI:10.3390/molecules25235656