دورية أكاديمية
Long-term growth hormone treatment preserves GH-induced memory and mood improvements:a 10-year follow-up study in GH-deficient adult men
| العنوان: | Long-term growth hormone treatment preserves GH-induced memory and mood improvements:a 10-year follow-up study in GH-deficient adult men |
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| المؤلفون: | Arwert, Lucia I, Deijen, Jan Berend, Müller, Maartje, Drent, Madeleine L |
| المصدر: | Arwert , L I , Deijen , J B , Müller , M & Drent , M L 2005 , ' Long-term growth hormone treatment preserves GH-induced memory and mood improvements : a 10-year follow-up study in GH-deficient adult men ' , Hormones and Behavior , vol. 47 , no. 3 , pp. 343-9 . https://doi.org/10.1016/j.yhbeh.2004.11.015Test |
| سنة النشر: | 2005 |
| الوصف: | Growth hormone (GH) replacement therapy with duration of several years is known to be safe and beneficial in GH-deficient adult patients. However, long-term follow-up data on GH substitution, cognition, and well-being are scarce. The purpose of this study was to investigate whether the benefits of GH replacement in psychological functioning found in previous studies lasting up to 2 years are preserved over a 10-year follow-up period. Twenty-three men (mean age at baseline 28.6 years) with childhood-onset GH deficiency were studied during a 10-year period of GH substitution. Memory tasks, mood questionnaires, and IGF-I values were obtained at baseline and after 0.5, 1, 2, 3, 5, and 10 years of GH substitution. Both mood and memory improved during GH therapy. After 6 months of treatment, anxiety and tension were reduced and vigor had improved. Memory improved after 1 year of substitution. These improvements were maintained during the 10-year follow-up period. Higher intra-subject IGF-I levels were associated with better mood (anxiety, tension, vigor). This study shows that 10 years of GH therapy is beneficial in terms of well-being and cognitive functioning in childhood-onset GH-deficient men. It may be concluded that once the decision to start GH treatment has been taken, this may imply that GH therapy has to be continued for a long period to maintain the psychological improvements and to prevent a relapse. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/10996fa5-27e1-46f1-ae6f-785defb1b635Test |
| DOI: | 10.1016/j.yhbeh.2004.11.015 |
| الإتاحة: | https://doi.org/10.1016/j.yhbeh.2004.11.015Test https://research.vumc.nl/en/publications/10996fa5-27e1-46f1-ae6f-785defb1b635Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.B52510F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.yhbeh.2004.11.015 |
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