دورية أكاديمية
T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL
| العنوان: | T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL |
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| المؤلفون: | Kristensen, T, Ebdrup, BH, Hjorthøj, C, Mandl, RCW, Mitta Raghava, J, Møllegaard Jepsen, JR, Fagerlund, B, Glenthøj, LB, Wenneberg, C, Krakauer, K, Pantelis, C, Glenthøj, BY, Nordentoft, M |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Background Individuals at ultra-high risk for psychosis (UHR) present with subtle white matter alterations, which have been associated with clinical and functional outcome. The effect of cognitive remediation on white matter (WM) in UHR-individuals has not been investigated. Methods In a randomized, clinical intervention-trial (FOCUS), UHR-individuals aged 18–40 years were assigned to treatment as usual (TAU) or TAU plus cognitive remediation (CR) for 20 weeks. CR comprised 20 x 2-hour sessions of neurocognitive and social-cognitive training (SCIT). Primary outcome was whole brain fractional anisotropy (FA) derived from diffusion weighted imaging. Secondary outcomes pertained to regions of interest analyses. Planned post-hoc analyses explored dose-response effects of CR on WM. Main analyses of treatment effect of CR on primary and secondary outcomes were conducted using linear mixed models, assessing the interaction of timepoint by group (CR and TAU). Analyses were conducted according to the intention-to-treat principle. Results 111 UHR-individuals and 59 healthy controls were included. Attrition-rate was 30% at 6 months post-treatment follow-up. The CR group completed a mean of 12 hours of neurocognitive training. We found no effect of CR on whole-brain or regional FA. Planned post-hoc analyses revealed significant time*group (high- and low-attendance to CR) interactions in left superior corona radiata (p<0.01), left cingulum cingulate gyrus (P=0.03), and right superior longitudinal fasciculus (P<0,01), corrected. Specifically, when compared to UHR-individuals with high attendance (UHR-high >12 hours), those with low attendance (UHR-low <12 hours) had more co-morbid diagnoses, larger recreational smoking (nicotine and cannabis), more depressive and negative symptoms, and had significantly lower global FA at baseline, and showed a significant increase in FA after treatment. Furthermore, UHR-low displayed large effect-size (ES) improvements on depressive and negative symptoms, and moderate to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0586-7614 1745-1701 |
| العلاقة: | Kristensen, T., Ebdrup, B. H., Hjorthøj, C., Mandl, R. C. W., Mitta Raghava, J., Møllegaard Jepsen, J. R., Fagerlund, B., Glenthøj, L. B., Wenneberg, C., Krakauer, K., Pantelis, C., Glenthøj, B. Y. & Nordentoft, M. (2020). T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL. Schizophrenia Bulletin, 46 (Supplement_1), pp.S237-S238. https://doi.org/10.1093/schbul/sbaa029.578Test.; http://hdl.handle.net/11343/273881Test |
| الإتاحة: | https://doi.org/10.1093/schbul/sbaa029.578Test http://hdl.handle.net/11343/273881Test |
| حقوق: | CC BY-NC ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.7F389F91 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 05867614 17451701 |
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