التفاصيل البيبلوغرافية
| العنوان: |
Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19 : a randomised clinical trial |
| المؤلفون: |
Agustí, Àlvar, De Stefano, Gaston, Levi, Alberto, Muñoz Gall, Xavier, Romero-Mesones, Christian, Sibila, Oriol, Lopez-Giraldo, Alejandra, Moral, Vicente Plaza, Curto Sánchez, Elena, Echazarreta, Andrés L., Márquez, Silvana E., Pascual-Guàrdia, Sergi, Santos, Salud, Marín, Alicia, Valdés, Luis, Saldarini, Fernando, Salgado, Clara, Casanovas Mateu, Georgina, Varea, Sara, Ríos, José, Faner, Rosa |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| الوصف: |
SARS-CoV-2 vaccines have been extremely effective to reduce the incidence of severe COVID19 [1-3], but effective and safe treatments of the acute infection are still limited [4, 5]. An uncontrolled pulmonary inflammatory response to SARS-CoV-2 is considered a key pathogenic mechanism of COVID19 progression [6], so systemic dexamethasone is recommended in severe cases [5, 7]. On the other hand, in very mild patients at home inhaled corticosteroids (ICS) may prevent disease progression [8-11]. Whether ICS prevent disease progression too in patients hospitalised because of COVID19 has not been explored before. Accordingly, we designed an investigator-initiated, open-label, randomised clinical trial (RCT) to explore the efficacy of adding inhaled budesonide to usual care to prevent disease progression in patients hospitalised because of COVID19 pneumonia. We also monitored carefully the safety of this intervention since there are concerns about the use of systemic corticosteroids in other viral (influenza) lung infections [12]. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
13993003 |
| العلاقة: |
European respiratory journal; february 2022; https://ddd.uab.cat/record/256018Test; urn:10.1183/13993003.03036-2021; urn:oai:ddd.uab.cat:256018; urn:pmcid:PMC8832375; urn:pmc-uid:8832375; urn:pmid:35144989; urn:oai:pubmedcentral.nih.gov:8832375; urn:oai:egreta.uab.cat:publications/f8feee72-da6b-4c8f-a82f-2cfe01dfa887; urn:scopus_id:85126389839 |
| الإتاحة: |
https://ddd.uab.cat/record/256018Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.3AFFB026 |
| قاعدة البيانات: |
BASE |
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