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المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
المصدر: Journal of Medicinal Chemistry. 64:2937-2952
مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3Test
https://doi.org/10.1021/acs.jmedchem.0c02008Test -
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المؤلفون: Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
المصدر: Journal of Medicinal Chemistry. 63:13526-13545
مصطلحات موضوعية: 0303 health sciences, Allosteric modulator, Drug discovery, Antagonist, Guanosine, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Sulfasalazine, Drug Discovery, medicine, GPR84, Molecular Medicine, Potency, Receptor, 030304 developmental biology, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85Test
https://doi.org/10.1021/acs.jmedchem.0c00272Test -
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المؤلفون: Catherine Robin-Jagerschmidt, Helene Jary, Ellen van der Aar, Nicolas Triballeau, Luke Jonathan Alvey, Francois Nique, Denis Guédin, Kris Van Beeck, Dominque Minet, Florence Namour, Jean H.M. Feyen, Pierre Deprez, Hugo Klaassen, Jean-Michel Lefrancois, Roland Blanque, Christophe Peixoto, Murielle Manioc, Séverine Hebbe, Stephen Robert Fletcher, Christopher Gaëtan Housseman
المصدر: Journal of Medicinal Chemistry. 55:8236-8247
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Stereochemistry, Molecular Conformation, Biological Availability, Hydantoin, Pharmacology, Partial agonist, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Anabolic Agents, In vivo, Drug Discovery, Androgen Receptor Antagonists, Animals, Humans, Hydroxymethyl, Muscle, Skeletal, Trifluoromethyl, Hydantoins, Prostate, Stereoisomerism, Organ Size, Rats, Bioavailability, Drug Partial Agonism, Androgen receptor, chemistry, Selective androgen receptor modulator, Receptors, Androgen, Androgens, Molecular Medicine, Orchiectomy, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841982488e4fec11bfd3145a00ecb1c9Test
https://doi.org/10.1021/jm300281xTest