المؤلفون: Yingli ZHU, Hongshun GU, Jianjun ZHANG, Xiangshan WANG, Weican LIANG, Yingxin SHAO, Fan ZHAO, Yang LI, Limei ZHANG, Linyuan WANG

المصدر: Shipin gongye ke-ji, Vol 44, Iss 14, Pp 290-295 (2023)

مصطلحات موضوعية: fermentum rubrum, hongqu fuling tablets, lovastatin, lovastatin acid, quantitative analysis of multi-components by single marker (qams), Food processing and manufacture, TP368-456

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1002-0306Test

الوصول الحر: https://doaj.org/article/90295c7dcd70429dbe2cb6db63a6ce57Test

المؤلفون: Wen-Ya Peng (10952330), Andy C. Huang (10952333), Chin-Tsung Ting (10952336), Tung-Hu Tsai (271408)

مصطلحات موضوعية: Biochemistry, Genetics, Physiology, Pharmacology, Biotechnology, Immunology, Marine Biology, Science Policy, Mental Health, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, chromatography-tandem mass spectrom., Coptidis preparation, metabolite lovastatin acid, dyslipidemia, half-dose lovastatin group, High-Fat Diet-Induced Hyperlipidemi., mg, p.o, HFD rats

العلاقة: https://figshare.com/articles/journal_contribution/Preclinical_Pharmacokinetics_and_Pharmacodynamics_of_Coptidis_Preparation_in_Combination_with_Lovastatin_in_High-Fat_Diet-Induced_Hyperlipidemic_Rats/14761883Test

الإتاحة: https://doi.org/10.1021/acsomega.1c01201.s001Test

المؤلفون: Chin Tsung Ting, Andy C. Huang, Tung Hu Tsai, Wen Ya Peng

المصدر: ACS Omega
ACS Omega, Vol 6, Iss 24, Pp 15804-15815 (2021)

مصطلحات موضوعية: business.industry, General Chemical Engineering, Metabolite, nutritional and metabolic diseases, General Chemistry, Pharmacology, medicine.disease, Article, Chemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Hyperlipidemia, polycyclic compounds, medicine, lipids (amino acids, peptides, and proteins), Lovastatin, Lovastatin Acid, business, QD1-999, Dyslipidemia, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a25a8178a72ab5786b28f77e6d47a72Test
https://doi.org/10.1021/acsomega.1c01201Test

المؤلفون: Xin Lin, Hua Xiang, Lizhe Zhu, Zhenbang Li, Xinyu Li, Kun Xi, Yu Chen, Guoshun Luo, Hanlin Wei, Maoxu Xiao

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1300-1314 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HMGCR, 3-hydroxy-3-methylglutaryl coenzyme A reductase, Statin, medicine.drug_class, PROTAC, proteolysis-targeting chimera, HDAC, histone deacetylase, RM1-950, Pharmacology, Protein degradation, Reductase, CVD, cardiovascular disease, PK, pharmacokinetic, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, PROTACs, In vivo, Oral administration, Oral bioavailability, SAR, structure–activity relationship, medicine, General Pharmacology, Toxicology and Pharmaceutics, CRBN, cereblon, 030304 developmental biology, HMGCR, 0303 health sciences, TG, triglyceride, Chemistry, Proteolysis targeting chimera, MFD, medium fat diet, H&E, hematoxylin/eosin, DC50, half degradation concentration, TC, total cholesterol, VHL, von Hippel-Lindau, Cholesterol reduction, 030220 oncology & carcinogenesis, Original Article, LDL-C, low-density lipoprotein cholesterol, lipids (amino acids, peptides, and proteins), Therapeutics. Pharmacology, Lovastatin Acid, ORO, oil-red O

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6312f6152cec18a667ff549cdcda8adeTest
http://www.sciencedirect.com/science/article/pii/S2211383520307772Test

المؤلفون: Wujian, J., Kuan-wei, P., Sihyung, Y., Huijing, S., Mario, S., Wang, Zhuo

مصطلحات موضوعية: Lovastatin, Lovastatin acid, UPLC-MS/MS, Polarity switching, Protein precipitation extraction, Pharmacokinetics

وصف الملف: application/pdf

العلاقة: Wujian J, Kuan-wei P, Sihyung Y, Huijing S, Mario S, et al. (2015) A Simple Protein Precipitation-based Simultaneous Quantification of Lovastatin and Its Active Metabolite Lovastatin Acid in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry using Polarity Switching. J Chromatogr Sep Tech 6:268. doi:10.4172/2157-7064.1000268; http://hdl.handle.net/1808/22285Test

الإتاحة: https://doi.org/10.4172/2157-7064.1000268Test
http://hdl.handle.net/1808/22285Test

المؤلفون: Reo Kawata, Tsuyoshi Yokoi

المصدر: International Journal of Toxicology. 38:192-201

مصطلحات موضوعية: Male, Necrosis, 040301 veterinary sciences, Pharmacology, Toxicology, 0403 veterinary science, 03 medical and health sciences, Dogs, Fenofibrate, Animals, Medicine, Drug Interactions, Lovastatin, Muscle, Skeletal, Creatine Kinase, Hypolipidemic Agents, 030304 developmental biology, 0303 health sciences, biology, Myoglobin, business.industry, Skeletal muscle, 04 agricultural and veterinary sciences, Drug interaction, MicroRNAs, medicine.anatomical_structure, biology.protein, Biomarker (medicine), Female, Creatine kinase, Lovastatin Acid, medicine.symptom, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f8b9f56fc6d4cd8541f06d250547eTest
https://doi.org/10.1177/1091581819844793Test

المؤلفون: Na Young Lim, Sun Hee Moon, Sun Young Baek, Hwan Seong Choi, Nam Sook Kim, Hyungil Kim, Ji Hyun Lee

المصدر: Rapid Communications in Mass Spectrometry. 35

مصطلحات موضوعية: Detection limit, Chromatography, Chemistry, Electrospray ionization, 010401 analytical chemistry, Organic Chemistry, Tandem mass spectrometry, 01 natural sciences, High-performance liquid chromatography, 0104 chemical sciences, Analytical Chemistry, Anti hyperlipidemic, Liquid chromatography electrospray ionization tandem mass spectrometry, medicine, Lovastatin, Lovastatin Acid, Spectroscopy, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3863ea99b5b3675658498ae74bffd21Test
https://doi.org/10.1002/rcm.8989Test

المؤلفون: Lei Yin, Yantong Sun, Xin Guan, Yan Yang, Xiangjun Meng, De-Li Wang

المصدر: Journal of Liquid Chromatography & Related Technologies. 41:668-675

مصطلحات موضوعية: Metabolite, Clinical Biochemistry, Pharmaceutical Science, Tandem mass spectrometry, 01 natural sciences, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, polycyclic compounds, medicine, Chromatography, organic chemicals, 010401 analytical chemistry, nutritional and metabolic diseases, 0104 chemical sciences, chemistry, Hplc ms ms, Human plasma, 030220 oncology & carcinogenesis, lipids (amino acids, peptides, and proteins), Lovastatin, Lovastatin Acid, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::54e01d27337f826241723997338790ddTest
https://doi.org/10.1080/10826076.2018.1508473Test

المؤلفون: François Bélanger, Jacques Turgeon, Jennifer Lu, Yat Hei Leung, Veronique Michaud

المصدر: Current Pharmaceutical Biotechnology. 18:1141-1150

مصطلحات موضوعية: Monocarboxylic Acid Transporters, 0301 basic medicine, Drug-Related Side Effects and Adverse Reactions, Cell Culture Techniques, Muscle Proteins, Pharmaceutical Science, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Muscular Diseases, Cell Line, Tumor, medicine, Animals, Humans, Lactic Acid, Myopathy, IC50, Symporters, Biological Transport, Cerivastatin, Lactic acid, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Efflux, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lovastatin Acid, medicine.symptom, Biotechnology, medicine.drug, Fluvastatin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a98c7a64a3d3893322a91a85e3ad5fTest
https://doi.org/10.2174/1389201019666180308091504Test

المؤلفون: Jingkai Gu, Xiujun Wu, Guilian Zhao, Guofei Li, Mei Liu, Feng Qiu, Limei Zhao

المصدر: Pharmacogenomics. 18:65-75

مصطلحات موضوعية: 0301 basic medicine, Receptors, Steroid, Cmax, Pharmacology, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Asian People, Pharmacokinetics, Genotype, polycyclic compounds, Genetics, ATP Binding Cassette Transporter, Subfamily G, Member 2, Cytochrome P-450 CYP3A, Humans, Medicine, PPAR alpha, Lovastatin, Allele, biology, CYP3A4, Liver-Specific Organic Anion Transporter 1, business.industry, Pregnane X Receptor, NF-kappa B p50 Subunit, nutritional and metabolic diseases, Healthy Volunteers, Neoplasm Proteins, 030104 developmental biology, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lovastatin Acid, business, SLCO1B1, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900d8c428d0f7e1169098f5fe9b623e5Test
https://doi.org/10.2217/pgs.16.31Test