التفاصيل البيبلوغرافية
| العنوان: |
COVID-19 Vaccine Antibody Response in a Single-Center Urban Hemodialysis Unit |
| المؤلفون: |
Mingyue He, Rui Song, Zakir Shaik, Crystal A. Gadegbeku, Louise Enderle, Christina Petyo, Sally B. Quinn, Zoe Pfeffer, Kathleen Murphy, Steven Kelsen, Aaron D. Mishkin, Jean Lee, Avrum Gillespie |
| المصدر: |
Vaccines, Vol 11, Iss 7, p 1252 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
COVID-19, mRNA vaccines, antibody response, hemodialysis, COVID-19 naïve, COVID-19 recovered, Medicine |
| الوصف: |
Background: The longitudinal response to the COVID-19 vaccines among patients on hemodialysis with and without prior SARS-CoV-2 infection has not been well characterized. Methods: To guide vaccination strategies in patients on hemodialysis, it is critical to characterize the longevity and efficacy of the vaccine; therefore, we conducted a prospective single-center monthly antibody surveillance study between March 2021 and March 2022 to investigate the dynamic humoral response to a series of COVID-19 mRNA vaccines in patients on hemodialysis with and without prior SARS-CoV-2 infection. Monthly quantitative antibody testing was performed using the Beckman Coulter Access SARS-CoV-2 IgG Antibody Test©, which detects IgG antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Results: This cohort of 30 participants (mean age: 61 ± 3 years) predominantly self-identified as African American (97%) and male (53%). Eight participants (27%) had recovered from COVID-19 (recovered) before the vaccine initiation. All participants received two vaccine doses, and 86.6% received a 6-month booster dose. Among patients naïve to COVID-19, the antibody positivity rate (APR) was 55% post-first-dose, 91% post-second-dose, 50% pre-booster at 6 months, 100% post-booster, and 89% at 6 months post-booster. Recovered patients sustained a consistent 100% APR throughout the year. The naïve patients demonstrated lower peak antibody levels post-second-dose than the recovered patients (17.9 ± 3.2 vs. 44.7 ± 5.6, p < 0.001). The peak antibody levels post-booster showed no significant difference between both groups (27.1 ± 3.9 vs. 37.9 ± 8.2, p = 0.20). Two naïve patients contracted COVID-19 during the follow-up period. Conclusions: The patients naïve to COVID-19 exhibited an attenuated and foreshortened antibody response following two doses of the mRNA vaccines compared with the recovered patients, who maintained 100% APR before the booster dose. The 6-month booster dose counteracted declining immunity and stimulated antibody responses in the naïve patients, even in previously non-responsive patients. This observation implies that different booster vaccination strategies might be required for COVID-19-naïve and -recovered patients. Post-vaccination antibody testing may serve as a valuable tool for guiding vaccination strategies. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| العلاقة: |
https://www.mdpi.com/2076-393X/11/7/1252Test; https://doaj.org/toc/2076-393XTest |
| DOI: |
10.3390/vaccines11071252 |
| الوصول الحر: |
https://doaj.org/article/b0d00971f26247bd972fd55b09591135Test |
| رقم الانضمام: |
edsdoj.b0d00971f26247bd972fd55b09591135 |
| قاعدة البيانات: |
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