دورية أكاديمية
Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms
| العنوان: | Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms |
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| المؤلفون: | McDowell, CM, Kizhatil, K, Elliott, MH, Overby, DR, Van Batenburg-Sherwood, J, Millar, JC, Kuehn, MH, Zode, G, Acott, TS, Anderson, MG, Bhattacharya, SK, Bertrand, JA, Borras, T, Bovenkamp, DE, Cheng, L, Danias, J, De Ieso, ML, Du, Y, Faralli, JA, Fuchshofer, R, Ganapathy, PS, Gong, H, Herberg, S, Hernandez, H, Humphries, P, John, SWM, Kaufman, PL, Keller, KE, Kelley, MJ, Kelly, RA, Krizaj, D, Kumar, A, Leonard, BC, Lieberman, RL, Liton, P, Liu, Y, Liu, KC, Lopez, NN, Mao, W, Mavlyutov, T, McDonnell, F, McLellan, GJ, Mzyk, P, Nartey, A, Pasquale, LR, Patel, GC, Pattabiraman, PP, Peters, DM, Raghunathan, V, Rao, PV, Rayana, N, Raychaudhuri, U, Reina-Torres, E, Ren, R, Rhee, D, Chowdhury, UR, Samples, JR, Samples, EG, Sharif, N, Schuman, JS, Sheffield, VC, Stevenson, CH, Soundararajan, A, Subramanian, P, Sugali, CK, Sun, Y, Toris, CB, Torrejon, KY, Vahabikashi, A, Vranka, JA, Wang, T, Willoughby, CE, Xin, C, Yun, H, Zhang, HF, Fautsch, MP, Tamm, ER, Clark, AF, Ethier, CR, Stamer, WD |
| بيانات النشر: | Association for Research in Vision and Ophthalmology |
| سنة النشر: | 2021 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, mouse model, conventional outflow, glaucoma, intraocular pressure, ocular hypertension, outflow facility, OPEN-ANGLE GLAUCOMA, TRABECULAR MESHWORK CELLS, OPTIC-NERVE DAMAGE, INTRAOCULAR-PRESSURE, EXTRACELLULAR-MATRIX, HYDROGEN-SULFIDE, RESCUES GLAUCOMA, HUMAN EYES, SYMPATHETIC NEUROTRANSMISSION, NONINVASIVE DETERMINATION, Animals, Aqueous Humor, Consensus, Disease Models, Animal, Mice, Tonometry, Ocular, Trabecular Meshwork |
| الوصف: | Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0146-0404 |
| العلاقة: | Investigative Ophthalmology and Visual Science; http://hdl.handle.net/10044/1/97554Test |
| DOI: | 10.1167/iovs.63.2.12 |
| الإتاحة: | https://doi.org/10.1167/iovs.63.2.12Test http://hdl.handle.net/10044/1/97554Test |
| حقوق: | Copyright 2022 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.F586EE09 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01460404 |
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| DOI: | 10.1167/iovs.63.2.12 |