دورية أكاديمية
Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger
| العنوان: | Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger |
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| المؤلفون: | Liu, Miaomaio, Yang, Yakun, Zhang, Muqing, Xue, Yucong, Zheng, Bin, Zhang, Yuanyuan, Liu, Yu, Chu, Xi, Sun, Zhenqing, Han, Xue |
| المساهمون: | Nature Fund of Hebei Province, Project of Science and Technology Research Project of Hebei Province |
| المصدر: | Journal of Pharmacy and Pharmacology ; volume 74, issue 8, page 1133-1139 ; ISSN 0022-3573 2042-7158 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmaceutical Science, Pharmacology |
| الوصف: | Objectives Gingerols are bioactive compounds derived from ginger, our experiment investigates the effects of 6-, 8- and 10-Gin on the human ether-à-go-go-related gene (hERG) K+ channels by using patch clamp technology. Key findings hERG K+ currents were suppressed by 6-, 8- and 10-Gin in a concentration-dependent manner. The IC50 values of 6-, 8- and 10-Gin were 41.5, 16.1 and 86.5 μM for the hERG K+ currents, respectively. The maximum inhibitory effects caused by 6-, 8- and 10-Gin were 44.3% ± 2.0%, 88.6% ± 1.3% and 63.1% ± 1.1%, respectively, and the effects were almost completely reversible. Conclusion These findings suggest that 8-Gin is the most potent hERG K+ channel inhibitor among gingerol components and may offer a new approach for understanding and treating cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jpp/rgac029 |
| الإتاحة: | https://doi.org/10.1093/jpp/rgac029Test https://academic.oup.com/jpp/article-pdf/74/8/1133/45480980/rgac029.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.1A23179E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jpp/rgac029 |
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