Plasma glucagon-like peptide-1 responses to ingestion of protein with increasing doses of milk minerals rich in calcium
| العنوان: | Plasma glucagon-like peptide-1 responses to ingestion of protein with increasing doses of milk minerals rich in calcium |
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| المؤلفون: | Aaron Hengist, Ulla Ramer Mikkelsen, Harry A Smith, Francoise Koumanov, Lise Høj Brunsgaard, James A. Betts, Javier T. Gonzalez, Jonathan D Watkins |
| المصدر: | British Journal of Nutrition. 128:55-63 |
| بيانات النشر: | Cambridge University Press (CUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nutrition and Dietetics, media_common.quotation_subject, Insulin, medicine.medical_treatment, Albumin, Medicine (miscellaneous), chemistry.chemical_element, Appetite, Calcium, Crossover study, Hydrolysate, Animal science, NEFA, chemistry, medicine, Ingestion, media_common |
| الوصف: | A high dose of whey protein hydrolysate fed with milk minerals rich in calcium (Capolac®) results in enhanced glucagon-like peptide-1 (GLP-1) concentrations in lean individuals; however, the effect of different calcium doses ingested alongside protein is unknown. The present study assessed the dose response of calcium fed alongside 25 g whey protein hydrolysate on GLP-1 concentrations in individuals with overweight/obesity. Eighteen adults (mean ± sd: 8M/10F, 34 ± 18 years, 28·2 ± 2·9 kgm−2) completed four trials in a randomised, double-blind, crossover design. Participants consumed test solutions consisting of 25 g whey protein hydrolysate (CON), supplemented with 3179 mg (LOW), 6363 mg (MED) or 9547 mg (HIGH) Capolac® on different occasions, separated by at least 48 h. The calcium content of test solutions equated to 65, 892, 1719 and 2547 mg, respectively. Arterialised-venous blood was sampled over 180 min to determine plasma concentrations of GLP-1TOTAL, GLP-17–36amide, insulin, glucose, NEFA, and serum concentrations of calcium and albumin. Ad libitum energy intake was measured at 180 min. Time–averaged incremental AUC (iAUC) for GLP-1TOTAL (pmol·l−1·min−1) did not differ between CON (23 ± 4), LOW (25 ± 6), MED (24 ± 5) and HIGH (24 ± 6). Energy intake (kcal) did not differ between CON (940 ± 387), LOW (884 ± 345), MED (920 ± 334) and HIGH (973 ± 390). Co-ingestion of whey protein hydrolysate with Capolac® does not potentiate GLP-1 release in comparison with whey protein hydrolysate alone. The study was registered at clinical trials (NCT03819972). |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd288a6547c8d8e412662c0681858760Test https://doi.org/10.1017/s000711452100297xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bd288a6547c8d8e412662c0681858760 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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