دورية أكاديمية
One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial
| العنوان: | One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial |
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| المؤلفون: | R. Pratley, M. Nauck, T. Bailey, E. Montanya, R. Cuddihy, A. Garber, A. b. Thomsen, H. Hartvig, M. Davies, Lira Dpp Study Group, FILETTI, SEBASTIANO |
| المساهمون: | R., Pratley, M., Nauck, T., Bailey, E., Montanya, R., Cuddihy, Filetti, Sebastiano, A., Garber, A. b., Thomsen, H., Hartvig, M., Davie, Lira Dpp Study, Group |
| بيانات النشر: | WILEY-BLACKWELL |
| سنة النشر: | 2011 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| الوصف: | P>Aim: The aim of this study was to compare the efficacy and safety of once-daily human glucagon-like peptide-1 analogue liraglutide with dipeptidyl peptidase-4 inhibitor sitagliptin, each added to metformin, over 52 weeks in individuals with type 2 diabetes. Methods: In an open-label, parallel-group trial, metformin-treated participants were randomised to liraglutide 1.2 mg/day (n = 225), liraglutide 1.8 mg/day (n = 221) or sitagliptin 100 mg/day (n = 219) for 26 weeks (main phase). Participants continued the same treatment in a 26-week extension. Results: Liraglutide (1.2 or 1.8 mg) was superior to sitagliptin for reducing HbA(1c) from baseline (8.4-8.5%) to 52 weeks: -1.29% and -1.51% vs. -0.88% respectively. Estimated mean treatment differences between liraglutide and sitagliptin were as follows: -0.40% (95% confidence interval -0.59 to -0.22) for 1.2 mg and -0.63% (-0.81 to -0.44) for 1.8 mg (both p < 0.0001). Weight loss was greater with liraglutide 1.2 mg (-2.78 kg) and 1.8 mg (-3.68 kg) than sitagliptin (-1.16 kg) (both p < 0.0001). Diabetes Treatment Satisfaction Questionnaire scores increased significantly more with liraglutide 1.8 mg than with sitagliptin (p = 0.03). Proportions of participants reporting adverse events were generally comparable; minor hypoglycaemia was 8.1%, 8.3% and 6.4% for liraglutide 1.2 mg, 1.8 mg and sitagliptin respectively. Gastrointestinal side effects, mainly nausea, initially occurred more frequently with liraglutide, but declined after several weeks. Conclusion: Liraglutide provides greater sustained glycaemic control and body weight reduction over 52 weeks. Treatment satisfaction was significantly greater with 1.8 mg liraglutide, similar to 26-week results. The safety profiles of liraglutide and sitagliptin are consistent with previous reports. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21355967; info:eu-repo/semantics/altIdentifier/wos/WOS:000288458300008; volume:65; issue:4; firstpage:397; lastpage:407; numberofpages:11; journal:INTERNATIONAL JOURNAL OF CLINICAL PRACTICE; http://hdl.handle.net/11573/357457Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79952755181; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000288458300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-79952755181&partnerID=65&md5=a63f7c3872fe23687b186d3a68e4d385Test |
| DOI: | 10.1111/j.1742-1241.2011.02656.x |
| الإتاحة: | https://doi.org/10.1111/j.1742-1241.2011.02656.xTest http://hdl.handle.net/11573/357457Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000288458300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-79952755181&partnerID=65&md5=a63f7c3872fe23687b186d3a68e4d385Test |
| رقم الانضمام: | edsbas.A8B32852 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1742-1241.2011.02656.x |
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