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1دورية أكاديمية
المؤلفون: Lindesmith, L, Brewer-Jensen, P, Mallory, M, Jensen, K, Yount, BL, Costantini, V, Collins, MH, Edwards, CE, Sheahan, TP, Vinjé, J, Baric, RS
المصدر: Cellular and Molecular Gastroenterology and Hepatology , 10 (2) pp. 245-267. (2020)
مصطلحات موضوعية: BACKGROUND & AIMS: Human norovirus infection is the leading cause of acute gastroenteritis. Genetic polymorphisms, mediated by the FUT2 gene (secretor enzyme), define strain susceptibility. Secretors express a diverse set of fucosylated histoblood group antigen carbohydrates (HBGA) on mucosal cells, nonsecretors (FUT2-/-) express a limited array of HBGAs. Thus, nonsecretors have less diverse norovirus strain infections, including resistance to the epidemiologically dominant GII.4 strains. Because future human norovirus vaccines will comprise GII.4 antigen and because secretor phenotype impacts GII.4 infection and immunity, nonsecretors may mimic young children immunologically in response to GII.4 vaccination, providing a needed model to study crossprotection in the context of limited pre-exposure. METHODS: By using specimens collected from the first characterized nonsecretor cohort naturally infected with GII.2 human norovirus, we evaluated the breadth of serologic immunity by surrogate neutralization assays, and cellular activation and cytokine production by flow cytometry. RESULTS: GII.2 infection resulted in broad antibody and cellular immunity activation that persisted for at least 30 days for T cells, monocytes, and dendritic cells, and for 180 days for blocking antibody. Multiple cellular lineages expressing interferon-g and tumor necrosis factor-a dominated the response. Both T-cell and B-cell responses were cross-reactive with other GII strains, but not GI strains. To promote entry mechanisms, inclusion of bile acids was essential for GII.2 binding to nonsecretor HBGAs. CONCLUSIONS: These data support development of withingenogroup, cross-reactive antibody and T-cell immunity, key outcomes that may provide the foundation for eliciting broad immune responses after GII.4 vaccination in individuals with limited GII.4 immunity, including young children. (
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10114780/1/1-s2.0-S2352345X20300424-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10114780Test/
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2دورية أكاديمية
المؤلفون: Sherwood, J., Sonderegger, I., Braun, R., Brinkman, A., Baric, R., Lindesmith, L.
المصدر: International Journal of Infectious Diseases ; volume 101, page 474 ; ISSN 1201-9712
مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), General Medicine
الإتاحة: https://doi.org/10.1016/j.ijid.2020.09.1241Test
https://api.elsevier.com/content/article/PII:S1201971220319573?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1201971220319573?httpAccept=text/plainTest -
3دورية أكاديمية
المؤلفون: Debbink, K., Lindesmith, L. C., Baric, R. S.
المصدر: Clinical Infectious Diseases ; volume 58, issue 12, page 1746-1752 ; ISSN 1058-4838 1537-6591
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4دورية أكاديمية
المؤلفون: Debbink, K., Lindesmith, L. C., Ferris, M. T., Swanstrom, J., Beltramello, M., Corti, D., Lanzavecchia, A., Baric, R. S.
المصدر: Journal of Virology, 88(13)
مصطلحات موضوعية: Capsid Proteins, Molecular Sequence Data, Humans, Amino Acid Sequence, Antigenic Variation, Epitopes, Caliciviridae Infections, Gastroenteritis, Antibodies, Viral, Norovirus, Immunocompromised Host, Biological Evolution, Disease Outbreaks
العلاقة: https://doi.org/10.17615/zbb6-cv27Test; https://cdr.lib.unc.edu/downloads/d791sq122?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/d791sq122Test
الإتاحة: https://doi.org/10.17615/zbb6-cv27Test
https://cdr.lib.unc.edu/downloads/d791sq122?file=thumbnailTest
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5دورية أكاديمية
المؤلفون: Lindesmith, L. C., Donaldson, E. F., Beltramello, M., Pintus, S., Corti, D., Swanstrom, J., Debbink, K., Jones, T. A., Lanzavecchia, A., Baric, R. S.
المصدر: Journal of Virology, 88(16)
مصطلحات موضوعية: Antibodies, Monoclonal, Capsid, Epitopes, Binding Sites, Gastroenteritis, Caliciviridae Infections, Virion, Viral, Norovirus, Capsid Proteins
العلاقة: https://doi.org/10.17615/ha3g-yn79Test; https://cdr.lib.unc.edu/downloads/37720m37z?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/37720m37zTest
الإتاحة: https://doi.org/10.17615/ha3g-yn79Test
https://cdr.lib.unc.edu/downloads/37720m37z?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/37720m37zTest -
6دورية أكاديمية
المؤلفون: Swanstrom, J., Lindesmith, L. C., Donaldson, E. F., Yount, B., Baric, R. S.
المصدر: Journal of Virology, 88(2)
مصطلحات موضوعية: Animals, Genotype, Caliciviridae Infections, Norovirus, Cross Reactions, Antibodies, Viral, Humans, Epitopes, Neutralization Tests, Mice
العلاقة: https://doi.org/10.17615/cg3t-5202Test; https://cdr.lib.unc.edu/downloads/d791sq11s?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/d791sq11sTest
الإتاحة: https://doi.org/10.17615/cg3t-5202Test
https://cdr.lib.unc.edu/downloads/d791sq11s?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/d791sq11sTest -
7دورية أكاديميةChimeric GII.4 Norovirus Virus-Like-Particle-Based Vaccines Induce Broadly Blocking Immune Responses
المؤلفون: Debbink, K., Lindesmith, L. C., Donaldson, E. F., Swanstrom, J., Baric, R. S.
المصدر: Journal of Virology, 88(13)
مصطلحات موضوعية: Animals, Mice, Inbred BALB C, Immunocompromised Host, Antibodies, Viral, Molecular Sequence Data, Protein Conformation, Antigenic Variation, Epitopes, Humans, Caliciviridae Infections, Norovirus, Capsid Proteins, Amino Acid Sequence
العلاقة: https://doi.org/10.17615/8gbq-7m68Test; https://cdr.lib.unc.edu/downloads/w6634999j?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/w6634999jTest
الإتاحة: https://doi.org/10.17615/8gbq-7m68Test
https://cdr.lib.unc.edu/downloads/w6634999j?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/w6634999jTest -
8Chimeric GII.4 Norovirus Virus-Like-Particle-Based Vaccines Induce Broadly Blocking Immune Responses
المؤلفون: Swanstrom, J., Debbink, K., Donaldson, E. F., Lindesmith, L. C., Baric, R. S.
مصطلحات موضوعية: viruses, virus diseases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0ff4e232f8c6cb72c20c432f9dc9cdedTest
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المؤلفون: Donaldson, E. F., Lindesmith, L. C., Yount, B., Baric, R. S., Swanstrom, J.
مصطلحات موضوعية: fluids and secretions, viruses, virus diseases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ad15015c8591e6e4fc84bf42987f0e59Test
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10دورية أكاديمية
المؤلفون: Lindesmith, L. C., Costantini, V., Swanstrom, J., Debbink, K., Donaldson, E. F., Vinje, J., Baric, R. S.
المصدر: Journal of Virology, 87(5)
مصطلحات موضوعية: Capsid Proteins, Mice, Disease Outbreaks, Animals, Evolution, Molecular, Antibodies, Monoclonal, Viral, Caliciviridae Infections, Epitopes, Humans, Immunity, Herd, Norovirus
العلاقة: https://doi.org/10.17615/bb8z-a721Test; https://cdr.lib.unc.edu/downloads/w3763f22w?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/w3763f22wTest
الإتاحة: https://doi.org/10.17615/bb8z-a721Test
https://cdr.lib.unc.edu/downloads/w3763f22w?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/w3763f22wTest