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1
المؤلفون: Amy Gustafson, Maureen Beresini, Linda O. Elliott, Robert Mintzer, Kevin R Clark, Christopher E. Heise, Cristina Lewis, Kinjalkumar Shah, Marya Liimatta, Yichin Liu, Adam R. Johnson, Stephen Schmidt
المصدر: SLAS Discovery. 17:225-236
مصطلحات موضوعية: High-throughput screening, Drug Evaluation, Preclinical, Computational biology, Biochemistry, Analytical Chemistry, Small Molecule Libraries, Physical chemical, Drug Discovery, False positive paradox, Animals, Humans, Computer Simulation, False Positive Reactions, Serum Albumin, Caspase 6, Chemistry, Drug discovery, Models, Theoretical, Combinatorial chemistry, High-Throughput Screening Assays, Carrier protein, Molecular Medicine, Cattle, gamma-Globulins, Protein Kinases, Peptide Hydrolases, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ce4af0acf15b02c1b2f4e674a015c6Test
https://doi.org/10.1177/1087057111421525Test -
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المؤلفون: Linda O. Elliott, Grace Mausisa, Heidi J.A. Wallweber, Wayne J. Fairbrother, Kurt Deshayes, Bainian Feng, Saloumeh Kadkhodayan
المصدر: ASSAY and Drug Development Technologies. 5:501-514
مصطلحات موضوعية: chemistry.chemical_classification, Chromatography, Drug discovery, Chemistry, Drug Evaluation, Preclinical, Biotin, Proteins, Fluorescence Polarization, Context (language use), Peptide, Fluoresceins, Small molecule, Molecular biology, Förster resonance energy transfer, Homogeneous, Data Interpretation, Statistical, Drug Discovery, Escherichia coli, Molecular Medicine, Electrochemiluminescence, Biological Assay, Peptides, Fluorescence anisotropy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4885c7c9cbb781bf7fd9226b5cd3756Test
https://doi.org/10.1089/adt.2007.070Test -
3
المؤلفون: Wayne J. Fairbrother, Kerry Zobel, Domagoj Vucic, Lan Wang, David C. Okawa, Eugene Varfolomeev, Matthew C. Franklin, Kurt Deshayes, Heidi J.A. Wallweber, Linda O. Elliott, John A. Flygare
المصدر: ACS Chemical Biology. 1:525-533
مصطلحات موضوعية: Models, Molecular, viruses, Protein domain, Apoptosis, Peptide binding, Plasma protein binding, Biology, Crystallography, X-Ray, Inhibitor of apoptosis, Biochemistry, Cell Line, Inhibitor of Apoptosis Proteins, Biomimetic Materials, Neoplasms, Humans, Inhibitor of apoptosis domain, Binding Sites, Activator (genetics), Intracellular Signaling Peptides and Proteins, General Medicine, Protein Structure, Tertiary, XIAP, Enzyme Activation, body regions, Caspases, Drug Design, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7aff58a10bd83f6299a6d6bcf85b298Test
https://doi.org/10.1021/cb600276qTest -
4
المؤلفون: Ulla M. Marzec, Stephen R. Hanson, Thomas E. Rawson, Mark Ultsch, Linda O. Elliott, Stuart Bunting, Maureen Beresini, Richard Goldsmith, David Banner, Daniel P. Sutherlin, Canio J. Refino, Dean R. Artis, Kirk Robarge, Charles Eigenbrot, Daniel Kirchhofer, Saloumeh Kadkhodayan, Olivero Alan G, John A. Flygare, Geralyn G. DeGuzman
المصدر: Journal of Biological Chemistry. 280:9160-9169
مصطلحات موضوعية: Models, Molecular, Proteases, Protein Conformation, Factor VIIa, Crystallography, X-Ray, Biochemistry, Serine, Tissue factor, Humans, Binding site, Molecular Biology, Serine protease, Sulfonamides, Binding Sites, biology, Chemistry, Active site, Hydrogen Bonding, Thrombosis, Cell Biology, Benzamidines, Kinetics, Coagulation, biology.protein, Oxyanion hole, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d3bde94402741ade5f76a9872bbf67Test
https://doi.org/10.1074/jbc.m409068200Test -
5
المؤلفون: Wayne J. Fairbrother, Kurt Deshayes, Domagoj Vucic, Matthew C. Franklin, Grace Mausisa, John A. Flygare, Saloumeh Kadkhodayan, Danny Ong, Daniela Alexandru, Linda O. Elliott, Heidi Ackerly, David C. Okawa, Mark D. Distefano
المصدر: Biochemistry. 42:8223-8231
مصطلحات موضوعية: Models, Molecular, X Chromosome, Genetic Linkage, Molecular Sequence Data, Peptide, Crystallography, X-Ray, Inhibitor of apoptosis, Biochemistry, Inhibitor of Apoptosis Proteins, Structure-Activity Relationship, Downregulation and upregulation, medicine, Amino Acid Sequence, neoplasms, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, Sequence Homology, Amino Acid, Chemistry, Melanoma, medicine.disease, Neoplasm Proteins, Structure and function, Apoptosis, Melanoma cell line, Immunology, Cancer research, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5017a4131d908778a66af2726fc406c6Test
https://doi.org/10.1021/bi034227tTest -
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المؤلفون: Andrew J. Wagner, Ron Yu, Sarah G. Hymowitz, S. Gail Eckhardt, Joanne Um, Shin G. Young, Bainian Feng, Maureen Beresini, Iris T. Chan, John A. Flygare, Domagoj Vucic, Jason Halladay, Jeffrey Tom, Linda O. Elliott, Karl Doerner, Sravanthi Cheeti, Heidi J.A. Wallweber, Lan Wang, Emile Plise, Lesley J. Murray, Vickie Tsui, Clifford Quan, Eugene Varfolomeev, Melisa L. Wong, Hank La, Frederick Cohen, Patricia LoRusso, Nageshwar Budha, Jonathan M. Wong, Jean Philippe Stephan, Kerry Zobel, Helen Chan, Joseph A. Ware, Lewis J. Gazzard, Matthew C. Franklin, Brigitte Maurer, Kurt Deshayes, Harvey Wong, Zhaoyang Wen, Wayne J. Fairbrother, Stacy Frankovitz Reisner, Susan Wong
المصدر: Journal of medicinal chemistry. 55(9)
مصطلحات موضوعية: Male, Apoptosis Inhibitor, Cell Survival, Ubiquitin-Protein Ligases, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Pharmacology, Inhibitor of apoptosis, Binding, Competitive, Article, Inhibitor of Apoptosis Proteins, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Thiadiazoles, medicine, Baculoviral IAP Repeat-Containing 3 Protein, Animals, Humans, Clinical Trials, Phase I as Topic, Chemistry, Antagonist, Cancer, medicine.disease, XIAP, Caspases, Molecular Medicine, Female
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9208ca80147ccd15bd753ab49f8a997aTest
https://pubmed.ncbi.nlm.nih.gov/22413863Test -
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المؤلفون: Vickie Tsui, Philippe Bergeron, Kevin Lau, Stephen F. Keteltas, John A. Flygare, Linda O. Elliott, Cuong Ly, Frederick Cohen, Wayne J. Fairbrother, Michael F. T. Koehler, Lewis J. Gazzard, Matthew C. Franklin
المصدر: Bioorganicmedicinal chemistry letters. 20(7)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Peptidomimetic, Clinical Biochemistry, Pharmaceutical Science, Inhibitor of apoptosis, Crystallography, X-Ray, Biochemistry, Protein–protein interaction, Inhibitor of Apoptosis Proteins, chemistry.chemical_compound, Biomimetics, Amide, Drug Discovery, Humans, Binding site, Thiazole, Molecular Biology, Binding Sites, Organic Chemistry, Amides, Thiazoles, chemistry, Benzothiazole, Molecular Medicine, Peptides, Fluorescence anisotropy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6b64886105a2be8e94bde6933dbfe3Test
https://pubmed.ncbi.nlm.nih.gov/20189383Test -
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المؤلفون: Tatiana Goncharov, Wayne J. Fairbrother, Bruno Alicke, Matthew C. Franklin, Frederick Cohen, Harvey Wong, Domagoj Vucic, John A. Flygare, Stacy Frankovitz, Linda O. Elliott, Jean-Philippe Stephan, Vickie Tsui, Stephen F. Keteltas
المصدر: Journal of medicinal chemistry. 52(6)
مصطلحات موضوعية: Models, Molecular, biology, Chemistry, Administration, Oral, Biological Availability, Biological activity, Inhibitor of apoptosis, Octanes, In vitro, XIAP, Inhibitor of Apoptosis Proteins, Structure-Activity Relationship, Biochemistry, Cell culture, Apoptosis, In vivo, Cell Line, Tumor, Drug Discovery, Cancer research, biology.protein, Molecular Medicine, Humans, Azabicyclo Compounds, Caspase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bf978852d44af93f03b709c4356ff5Test
https://pubmed.ncbi.nlm.nih.gov/19228017Test -
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المؤلفون: Kurt Deshayes, Kanad Das, Hwain Shin, Wayne J. Fairbrother, Saloumeh Kadkhodayan, Brendan P. Eckelman, Heidi J.A. Wallweber, Guy S. Salvesen, Linda O. Elliott, Domagoj Vucic, Matthew C. Franklin
مصطلحات موضوعية: musculoskeletal diseases, viruses, Caspase 2, Apoptosis, Inhibitor of apoptosis, Biochemistry, Inhibitor of Apoptosis Proteins, Mitochondrial Proteins, Molecular Biology, Caspase, Inhibitor of apoptosis domain, Caspase-9, biology, Activator (genetics), Proteins, Cell Biology, Molecular biology, Caspase Inhibitors, XIAP, body regions, Caspases, biology.protein, biological phenomena, cell phenomena, and immunity, Carrier Proteins, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522a4005dbdce82a8d8d73ec38a342daTest
https://europepmc.org/articles/PMC1134668Test/ -
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المؤلفون: Stephen F. Keteltas, Lewis J. Gazzard, Matthew C. Franklin, Vickie Tsui, Linda O. Elliott, Philippe Bergeron, Frederick Cohen, Cuong Ly, Michael F. T. Koehler, Wayne J. Fairbrother, Kevin Lau, John A. Flygare
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:753-754
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Amide, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Inhibitor of apoptosis, Thiazole, Molecular Biology, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6f86174814e3201d3c0a1f91076b308bTest
https://doi.org/10.1016/j.bmcl.2011.11.056Test