المؤلفون: Hirvonen, M. Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D., Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Orešič, Matej, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital

مصطلحات موضوعية: Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure was created with Biorender.com. The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure 1 was created with Biorender.com.; Hirvonen , M K , Lietzén , N , Moulder , R , Bhosale , S D , Koskenniemi , J , Vähä-Mäkilä , M , Nurmio , M , Orešič , M , Ilonen , J , Toppari , J , Veijola , R , Hyöty , H , Lähdesmäki , H , Knip , M , Cheng , L & Lahesmaa , R 2023 , ' Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes ' , Scientific Reports , vol. 13 , no. 1 , 15941 . https://doi.org/10.1038/s41598-023-43039-4Test; http://hdl.handle.net/10138/569639Test; f7c92475-6b63-441d-90c6-f70646434629; 85171842365

الإتاحة: http://hdl.handle.net/10138/569639Test

المؤلفون: Laajala, Essi, Kalim, Ubaid Ullah, Grönroos, Toni, Rasool, Omid, Halla-Aho, Viivi, Konki, Mikko, Kattelus, Roosa, Mykkänen, Juha, Nurmio, Mirja, Vähä-Mäkilä, Mari, Kallionpää, Henna, Lietzén, Niina, Ghimire, Bishwa R., Laiho, Asta, Hyöty, Heikki, Elo, Laura L., Ilonen, Jorma, Knip, Mikael, Lund, Riikka J., Oresic, Matej, 1967, Veijola, Riitta, Lähdesmäki, Harri, Toppari, Jorma, Lahesmaa, Riitta

المصدر: Diabetologia. 65(9):1534-1540

مصطلحات موضوعية: Bisulphite sequencing, DNA methylation, Epigenomics, Follow-up study, Type 1 diabetes, Umbilical cord blood

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99651Test
https://doi.org/10.1007/s00125-022-05726-1Test

المؤلفون: Laajala, Essi, Halla-Aho, Viivi, Grönroos, Toni, Kalim, Ubaid Ullah, Vähä-Mäkilä, Mari, Nurmio, Mirja, Kallionpää, Henna, Lietzén, Niina, Mykkänen, Juha, Rasool, Omid, Toppari, Jorma, Oresic, Matej, 1967, Knip, Mikael, Lund, Riikka, Lahesmaa, Riitta, Lähdesmäki, Harri

المصدر: Epigenetics. 17(12):1608-1627

مصطلحات موضوعية: DNA methylation, RRBS, analysis workflow, bisulphite sequencing, differential methylation, pregnancy, sex, spatial correlation, type 1 error, umbilical cord blood

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97835Test
https://doi.org/10.1080/15592294.2022.2044127Test

المؤلفون: Hirvonen, M Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D, Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Oresic, Matej, 1967, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta

المصدر: Scientific Reports. 13(1)

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108493Test
https://doi.org/10.1038/s41598-023-43039-4Test

المؤلفون: on behalf of the INNODIA Consortium, Moulder, Robert, Välikangas, Tommi, Hirvonen, M. Karoliina, Suomi, Tomi, Brorsson, Caroline A., Lietzén, Niina, Bruggraber, Sylvaine F.A., Overbergh, Lut, Dunger, David B., Peakman, Mark, Chmura, Piotr J., Brunak, Soren, Schulte, Anke M., Mathieu, Chantal, Knip, Mikael, Elo, Laura L., Lahesmaa, Riitta

المساهمون: Tampere University, LAST, Paediatrics

مصطلحات موضوعية: 3121 Internal medicine

وصف الملف: fulltext

العلاقة: 11; 66; https://trepo.tuni.fi/handle/10024/152279Test; URN:NBN:fi:tuni-202309298544

الإتاحة: https://doi.org/10.1007/s00125-023-05974-9Test
https://trepo.tuni.fi/handle/10024/152279Test

المؤلفون: Moulder, Robert, Valikangas, Tommi, Hirvonen, M. Karoliina, Suomi, Tomi A., Brorsson, Caroline A., Lietzen, Niina, Bruggraber, Sylvaine F. A., Overbergh, Lut, Dunger, David B., Peakman, Mark, Chmura, Piotr J., Brunak, Soren, Schulte, Anke M., Mathieu, Chantal, Knip, Mikael, Elo, Laura L., Lahesmaa, Riitta

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Research Programs Unit, Lastentautien yksikkö, Children's Hospital

مصطلحات موضوعية: C-peptide, Glutathione peroxidase 3, Serum proteomics, Type 1 diabetes, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Moulder , R , Valikangas , T , Hirvonen , M K , Suomi , T A , Brorsson , C A , Lietzen , N , Bruggraber , S F A , Overbergh , L , Dunger , D B , Peakman , M , Chmura , P J , Brunak , S , Schulte , A M , Mathieu , C , Knip , M , Elo , L L & Lahesmaa , R 2023 , ' Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory ' , Diabetologia , vol. 66 , pp. 1983–1996 . https://doi.org/10.1007/s00125-023-05974-9Test; http://hdl.handle.net/10138/565893Test; 0705a6fd-a799-4043-908d-a86c3285daa6; 001042586200002

الإتاحة: http://hdl.handle.net/10138/565893Test

المؤلفون: Laajala, Essi, Halla-Aho, Viivi, Grönroos, Toni, Kalim, Ubaid Ullah, Vähä-Mäkilä, Mari, Nurmio, Mirja, Kallionpaa, Henna, Lietzen, Niina, Mykkänen, Juha, Rasool, Omid, Toppari, Jorma, Oresic, Matej, Knip, Mikael, Lund, Riikka, Lahesmaa, Riitta, Lähdesmäki, Harri

المساهمون: Institute of Biotechnology, HUS Children and Adolescents, Children's Hospital, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: DNA methylation, bisulphite sequencing, RRBS, umbilical cord blood, pregnancy, sex, spatial correlation, type 1 error, differential methylation, analysis workflow, MATERNAL SMOKING, 3123 Gynaecology and paediatrics, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: This research was supported by InFLAMES Flagship Programme of the Academy of Finland (decision number: 337530). R.La. received funding from the Academy of Finland (grants 292335, 294337, 319280, 31444, 319280, 329277, 331790), Business Finland, and by grants from the JDRF, the Sigrid Juselius Foundation (SJF), Jane and Aatos Erkko Foundation, Novo Nordisk Foundation, Finnish Diabetes Foundation and the Finnish Cancer Foundation. R.La., H.L., M.K., M.O., and J.T. were supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) grant 250114 and grant 292482. J.T. was funded by EFSD, Pediatric Research Foundation, and Turku University Hospital Special Governmental Grants, JDRF, and the Academy of Finland. E.L. was supported by Turku Doctoral Programme of Molecular Medicine (TuDMM), Finnish Cultural Foundation, and Kyllikki and Uolevi Lehikoinen Foundation. V.H. was supported by the Academy of Finland (292660, 311584, 335436). T.G. was supported by the Academy of Finland (decision number: 340231).; Laajala , E , Halla-Aho , V , Grönroos , T , Kalim , U U , Vähä-Mäkilä , M , Nurmio , M , Kallionpaa , H , Lietzen , N , Mykkänen , J , Rasool , O , Toppari , J , Oresic , M , Knip , M , Lund , R , Lahesmaa , R & Lähdesmäki , H 2022 , ' Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples ' , Epigenetics , vol. 17 , no. 12 , pp. 1608-1627 . https://doi.org/10.1080/15592294.2022.2044127Test; 834029f6-b8ac-47ff-9ad2-172d2f16a28c; http://hdl.handle.net/10138/353707Test; 000764920200001

الإتاحة: http://hdl.handle.net/10138/353707Test

المؤلفون: Välikangas, Tommi, Lietzén, Niina, Jaakkola, Maria K., Krogvold, Lars, Eike, Morten C., Kallionpää, Henna, Tuomela, Soile, Mathews, Clayton, Gerling, Ivan C., Oikarinen, Sami, Hyöty, Heikki, Dahl-Jorgensen, Knut, Elo, Laura L., Lahesmaa, Riitta

المساهمون: Tampere University, BioMediTech, Department of Clinical Microbiology

مصطلحات موضوعية: 3111 Biomedicine, 3121 Internal medicine

وصف الملف: fulltext

العلاقة: 861985; 13; https://trepo.tuni.fi/handle/10024/140250Test; URN:NBN:fi:tuni-202205164945

الإتاحة: https://doi.org/10.3389/fendo.2022.861985Test
https://trepo.tuni.fi/handle/10024/140250Test

المؤلفون: Buchacher, Tanja, Honkimaa, Anni, Välikangas, Tommi, Lietzén, Niina, Hirvonen, M. Karoliina, Laiho, Jutta E., Sioofy-Khojine, Amir Babak, Eskelinen, Eeva Liisa, Hyöty, Heikki, Elo, Laura L., Lahesmaa, Riitta

المساهمون: Tampere University, Clinical Medicine, BioMediTech, Department of Clinical Microbiology

مصطلحات موضوعية: 3111 Biomedicine

وصف الملف: fulltext

العلاقة: 103653; 25; ORCID: /0000-0001-5538-5153/work/106482620; https://trepo.tuni.fi/handle/10024/136812Test; URN:NBN:fi:tuni-202201121259

الإتاحة: https://doi.org/10.1016/j.isci.2021.103653Test
https://trepo.tuni.fi/handle/10024/136812Test

المؤلفون: Lietzén, Niina, Hirvonen, Karoliina, Honkimaa, Anni, Buchacher, Tanja, Laiho, Jutta E., Oikarinen, Sami, Mazur, Magdalena A., Flodström-Tullberg, Malin, Dufour, Eric, Sioofy-Khojine, Amir-Babak, Hyöty, Heikki, Lahesmaa, Riitta

المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University

مصطلحات موضوعية: Biological Sciences, Microbiology, Proteomics, Virology, Biokemia, solu- ja molekyylibiologia - Biochemistry, cell and molecular biology, Kasvibiologia, mikrobiologia, virologia - Plant biology, Genetiikka, kehitysbiologia, fysiologia - Genetics, developmental biology, physiology

وصف الملف: fulltext; 340-357

العلاقة: iScience; 19; https://trepo.tuni.fi/handle/10024/117319Test; URN:NBN:fi:tuni-201910073728

الإتاحة: https://trepo.tuni.fi/handle/10024/117319Test