المؤلفون: HU Yu, XIE Liang, ZOU Dan, FU Hongling, LOU Lili, XIE Keqi, LIU Hanmin

المصدر: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 5, Pp 580-591 (2023)

مصطلحات موضوعية: asthma, 5-lipoxygenase activating protein (alox5ap), leukotriene a4 hydrolase (lta4h), leukotriene b4 receptor, montelukast, Medicine

وصف الملف: electronic resource

العلاقة: https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-580.shtmlTest; https://doaj.org/toc/1674-8115Test

الوصول الحر: https://doaj.org/article/bef87b714fbc4672be38f2bb0d5e183bTest

المؤلفون: Yao Cai, Xia Mu, Guohui Li, Dingguo Xu

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Physiology, Biotechnology, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, zinc bifunctional enzyme, mechanistic insights garnered, limiting step within, isomeric conjugate (<, general base catalyst, general acid catalyst, epoxy ring opening, epoxy oxygen atom, computations firmly support, na stages constitute, molecular mechanical elucidation, leukotriene a4 hydrolase, active site ’, entire epoxidase mechanism, lta4h catalytic role, catalytic mechanism, quantum mechanical, na ), lta4h ’

العلاقة: https://figshare.com/articles/journal_contribution/Quantum_Mechanical_Molecular_Mechanical_Elucidation_of_the_Catalytic_Mechanism_of_Leukotriene_A4_Hydrolase_as_an_Epoxidase/24639462Test

الإتاحة: https://doi.org/10.1021/acs.jpcb.3c05969.s001Test
https://figshare.com/articles/journal_contribution/Quantum_Mechanical_Molecular_Mechanical_Elucidation_of_the_Catalytic_Mechanism_of_Leukotriene_A4_Hydrolase_as_an_Epoxidase/24639462Test

المؤلفون: Gebhard Thoma, Christian Markert, Rainer Lueoend, Wolfgang Miltz, Carsten Spanka, Birgit Bollbuck, Romain M. Wolf, Honnappa Srinivas, Carlos A. Penno, Michael Kiffe, Monika Gajewska, Dallas Bednarczyk, Grazyna Wieczorek, Amanda Evans, Christian Beerli, Till A. Röhn

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, orally efficacious inhibitors, leukotriene a4 hydrolase, exhibiting high selectivity, enabling toxicology studies, despite comparable stabilities, showed favorable profiles, hepatic blood flow, vivo pk properties, lys006 , 2 , showed distinct, whole blood, blood led, r <, >)-< b, week ind, polarity across, liver microsomes

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_Amino_Alcohols_as_Highly_Potent_Selective_and_Orally_Efficacious_Inhibitors_of_Leukotriene_A4_Hydrolase/24649684Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01866.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Amino_Alcohols_as_Highly_Potent_Selective_and_Orally_Efficacious_Inhibitors_of_Leukotriene_A4_Hydrolase/24649684Test

المؤلفون: Tarvi Teder, Stefanie König, Rajkumar Singh, Bengt Samuelsson, Oliver Werz, Ulrike Garscha, Jesper Z. Haeggström

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 8, p 7539 (2023)

مصطلحات موضوعية: 5-lipoxygenase, aminopeptidase, inflammation, leukotriene A4 hydrolase, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/24/8/7539Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/c79294583b1b4a64850cd27f0f44a190Test

المؤلفون: Stsiapanava, Alena¹, Samuelsson, Bengt¹ bengt.samuelsson@ki.se, Haeggström, Jesper Z.¹ jesper.haeggstrom@ki.se

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 9/5/2017, Vol. 114 Issue 36, p9689-9694. 6p.

مصطلحات موضوعية: *LEUKOTRIENE A4 hydrolase, *EPOXIDE hydrolase, *CHEMOKINES, *NATURAL immunity, *DRUG design

المؤلفون: Canyelles-Niño, Miquel, González-Lafont, Àngels, Lluch López, Josep Maria

مصطلحات موضوعية: Leukotriens, Leukotriene A4 hydrolase, Enzyme catalysis, QM/MM calculations, Molecular dynamics simulations, Proinflammatory lipid mediators

وصف الملف: application/pdf

العلاقة: Agencia Estatal de Investigación PID2020-113764GB-I00; International journal of molecular sciences; Vol. 23 Núm. 6 (Març 2022), p. 3140; https://ddd.uab.cat/record/257298Test; urn:10.3390/ijms23063140; urn:oai:ddd.uab.cat:257298; urn:scopus_id:85126283863; urn:articleid:14220067v23n6p3140; urn:pmid; urn:pmc-uid:8954237; urn:pmcid:PMC8954237; urn:oai:pubmedcentral.nih.gov:8954237; urn:pmid:35328561; urn:oai:egreta.uab.cat:publications/7a2d059d-6b7a-4ff8-8200-249ee50815b2

الإتاحة: https://ddd.uab.cat/record/257298Test

المؤلفون: Naomi Oi¹, Hiroyuki Yamamoto¹, Langfald, Alyssa¹, Bai, Ruihua¹, Mee-Hyun Lee¹, Bode, Ann M.¹, Zigang Dong¹ zgdong@hi.umn.edu

المصدر: Carcinogenesis. Jul2017, Vol. 38 Issue 7, p728-737. 10p.

مصطلحات موضوعية: *LEUKOTRIENE A4 hydrolase, *SKIN cancer, *CARCINOGENESIS, *CANCER prevention, *CANCER treatment, *CANCER cell growth

المؤلفون: Torres, María José^1,2, Fierro, Angélica², Pessoa-Mahana, C. David³, Romero-Parra, Javier^1,3, Cabrera, Gonzalo⁴, Faúndez, Mario¹ mfaundeza@uc.cl

المصدر: European Journal of Pharmacology. Mar2017, Vol. 799, p41-47. 7p.

مصطلحات موضوعية: *LIPOIC acid, *LEUKOTRIENE A4 hydrolase, *EPOXIDE hydrolase, *AMINOPEPTIDASES, *ANTIOXIDANTS, *IN vivo studies

المؤلفون: Miquel Canyelles-Niño, Àngels González-Lafont, José M. Lluch

المصدر: International Journal of Molecular Sciences, Vol 23, Iss 6, p 3140 (2022)

مصطلحات موضوعية: leukotriens, leukotriene A4 hydrolase, enzyme catalysis, QM/MM calculations, molecular dynamics simulations, proinflammatory lipid mediators, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/23/6/3140Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/d8275da40d20474d9b7b475ac1119b30Test

المؤلفون: Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll, Paul H Edelstein, Roger Sewell, Lalita Ramakrishnan

المصدر: eLife, Vol 10 (2021)

مصطلحات موضوعية: TB meningitis, leukotriene A4 hydrolase, pharmacogenomics, dexamethasone, Bayesian inference, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://elifesciences.org/articles/61722Test; https://doaj.org/toc/2050-084XTest

الوصول الحر: https://doaj.org/article/e5091ac19b1c47789b6044b32485ac7fTest