المؤلفون: Lüth, Theresa, Gabbert, Carolin, Koch, Sebastian, König, Inke R, Caliebe, Amke, Laabs, Björn-Hergen, Hentati, Faycel, Sassi, Samia Ben, Amouri, Rim, Spielmann, Malte, Klein, Christine, GRÜNEWALD, Anne, Farrer, Matthew J, Trinh, Joanne

المصدر: Movement Disorders, 38 (10), 1837 - 1849 (2023-10)

مصطلحات موضوعية: gene-environment interaction, mitochondrial genes, polygenic score, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, LRRK2 protein, human, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Age of Onset, Risk Factors, Life Style, Mutation, Protein Serine-Threonine Kinases/genetics, Parkinson Disease/complications, Parkinson Disease, Neurology, Neurology (clinical), Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

العلاقة: urn:issn:0885-3185; urn:issn:1531-8257; https://orbilu.uni.lu/handle/10993/57728Test; info:hdl:10993/57728; https://orbilu.uni.lu/bitstream/10993/57728/1/Movement%20Disorders%20-%202023%20-%20L%20th%20-%20Interaction%20of%20Mitochondrial%20Polygenic%20Score%20and%20Lifestyle%20Factors%20in%20LRRK2%20p%20Gly2019Ser.pdfTest; scopus-id:2-s2.0-85165555706; info:pmid:37482924; wos:001033699200001

الإتاحة: https://doi.org/10.1002/mds.29563Test
https://orbilu.uni.lu/handle/10993/57728Test
https://orbilu.uni.lu/bitstream/10993/57728/1/Movement%20Disorders%20-%202023%20-%20L%20th%20-%20Interaction%20of%20Mitochondrial%20Polygenic%20Score%20and%20Lifestyle%20Factors%20in%20LRRK2%20p%20Gly2019Ser.pdfTest

المؤلفون: Oun, Asmaa, Hoeksema, Emmy, Soliman, Ahmed, Brouwer, Famke, García-Reyes, Fabiola, Pots, Henderikus, Trombetta-Lima, Marina, Kortholt, Arjan, Dolga, Amalia M

المصدر: Oun , A , Hoeksema , E , Soliman , A , Brouwer , F , García-Reyes , F , Pots , H , Trombetta-Lima , M , Kortholt , A & Dolga , A M 2023 , ' Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages ' , International Journal of Molecular Sciences , vol. 24 , no. 2 , 1644 . https://doi.org/10.3390/ijms24021644Test

مصطلحات موضوعية: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Lipopolysaccharides/pharmacology, Reactive Oxygen Species, Signal Transduction, Macrophages/metabolism, Mutation

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/eb2afdd5-b9ca-44e7-b745-73aec74904ebTest

الإتاحة: https://doi.org/10.3390/ijms24021644Test
https://hdl.handle.net/11370/eb2afdd5-b9ca-44e7-b745-73aec74904ebTest
https://research.rug.nl/en/publications/eb2afdd5-b9ca-44e7-b745-73aec74904ebTest
https://pure.rug.nl/ws/files/565095629/ijms_24_01644_v2.pdfTest

المؤلفون: OLEKSY, Christiane, Massart, François, Goldwurm, Stefano, Arado, Alessia, ARENA, Giuseppe, BOUSSAAD, Ibrahim, Krüger, Rejko

المصدر: Stem Cell Research, 72, 103212 (2023-10)

مصطلحات موضوعية: LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Humans, Mutation/genetics, Fibroblasts/metabolism, Dopaminergic Neurons/metabolism, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Induced Pluripotent Stem Cells/metabolism, Parkinson Disease/genetics, Parkinson Disease/metabolism, Dopaminergic Neurons, Fibroblasts, Induced Pluripotent Stem Cells, Mutation, Parkinson Disease, Developmental Biology, Cell Biology, General Medicine, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques

العلاقة: https://api.elsevier.com/content/article/PII:S1873506123001988?httpAccept=text/xmlTest; urn:issn:1873-5061; urn:issn:1876-7753; https://orbilu.uni.lu/handle/10993/58996Test; info:hdl:10993/58996; https://orbilu.uni.lu/bitstream/10993/58996/1/Oleksy%20et%20al.%2c%202023.pdfTest; scopus-id:2-s2.0-85173821123; info:pmid:37832355; wos:001099165300001

الإتاحة: https://doi.org/10.1016/j.scr.2023.103212Test
https://orbilu.uni.lu/handle/10993/58996Test
https://orbilu.uni.lu/bitstream/10993/58996/1/Oleksy%20et%20al.%2c%202023.pdfTest

المصدر: PSP Genetics Group 2021 , ' Genetic determinants of survival in progressive supranuclear palsy : a genome-wide association study ' , The Lancet Neurology , vol. 20 , no. 2 , pp. 107-116 . https://doi.org/10.1016/S1474-4422Test(20)30394-X

مصطلحات موضوعية: Adult, Age of Onset, Aged, Chromosomes, Human, Pair 12/genetics, Databases, Genetic, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Kaplan-Meier Estimate, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, RNA, Long Noncoding/genetics, Supranuclear Palsy, Progressive/genetics, Survival Analysis, White People

العلاقة: https://pure.au.dk/portal/en/publications/63d5f2e5-6bef-4667-b949-546a111fa28eTest

الإتاحة: https://doi.org/10.1016/S1474-4422Test(20)30394-X
https://pure.au.dk/portal/en/publications/63d5f2e5-6bef-4667-b949-546a111fa28eTest
http://www.scopus.com/inward/record.url?scp=85099069662&partnerID=8YFLogxKTest

المؤلفون: Schneider, Susanne A., Hizli, Baccara, Alcalay, Roy N.

المصدر: http://lobid.org/resources/99370674841006441Test#!, 17(4):1378-1392.

مصطلحات موضوعية: TORC1 inhibitor, Deep Brain Stimulation/trends [MeSH], SNCA, GBA, Genetic Parkinson’s disease, Deep Brain Stimulation/methods [MeSH], alpha-Synuclein/genetics [MeSH], clinical trial, Parkinsonian Disorders/therapy [MeSH], Genetic Predisposition to Disease/genetics [MeSH], small molecule compounds, Mutation/genetics [MeSH], Genetic Predisposition to Disease/epidemiology [MeSH], Humans [MeSH], Precision Medicine/methods [MeSH], kinase inhibitor, ambroxol, Genetic Therapy/trends [MeSH], Precision Medicine/trends [MeSH], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics [MeSH], Clinical Trials as Topic/methods [MeSH], Parkinsonian Disorders/genetics [MeSH], Parkinsonian Disorders/epidemiology [MeSH], Review, Genetic Therapy/methods [MeSH], LRRK2, Venglustat

العلاقة: https://repository.publisso.de/resource/frl:6471320Test; https://doi.org/10.1007/s13311-020-00920-8Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483040Test/

الإتاحة: https://doi.org/10.1007/s13311-020-00920-8Test
https://repository.publisso.de/resource/frl:6471320Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483040Test/

المؤلفون: Schneider, Susanne A., Alcalay, Roy N.

المصدر: http://lobid.org/resources/99370671259506441Test#!, 267(3):860-869.

مصطلحات موضوعية: Genetic Predisposition to Disease [MeSH], TORC1 inhibitor, Mutation [MeSH], Kinase inhibitor, Humans [MeSH], Neurological Update, SNCA, Precision Medicine/methods [MeSH], Parkinson Disease/therapy [MeSH], GBA, Genetic Parkinson’s disease, Superprecision medicine, Parkinson Disease/genetics [MeSH], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics [MeSH], Glucosylceramidase/genetics [MeSH], Clinical Trials as Topic [MeSH], Clinical trial, Small molecule compounds, LRRK2, Molecular Targeted Therapy/methods [MeSH], Ambroxol, Venglustat

العلاقة: https://repository.publisso.de/resource/frl:6469650Test; https://doi.org/10.1007/s00415-020-09705-7Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035220Test/

الإتاحة: https://doi.org/10.1007/s00415-020-09705-7Test
https://repository.publisso.de/resource/frl:6469650Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035220Test/

المؤلفون: Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola García-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga

المساهمون: Molecular Pharmacology, Cell Biochemistry, Groningen Research Institute for Asthma and COPD (GRIAC)

المصدر: International Journal of Molecular Sciences, 24(2):1644. MDPI AG
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1644

مصطلحات موضوعية: Organic Chemistry, General Medicine, Lipopolysaccharides/pharmacology, Catalysis, Computer Science Applications, Inorganic Chemistry, Macrophages/metabolism, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Mutation, LRRK2, inflammation, LPS, cytokines, Physical and Theoretical Chemistry, Reactive Oxygen Species, Molecular Biology, Spectroscopy, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fc3223a882551609f5baeb49e724f3Test
https://doi.org/10.3390/ijms24021644Test

المؤلفون: Lis, Pawel, Burel, Sophie, Steger, Martin, Mann, Matthias, Brown, Fiona, Diez, Federico, Tonelli, Francesca, Holton, Janice L., Winglok Ho, Philip, Ho, Shu-Leong, Chou, Meng-Yun, Polinski, Nicole K., Martinez, Terina N., Davies, Paul, Alessi, Dario R.

المصدر: Lis , P , Burel , S , Steger , M , Mann , M , Brown , F , Diez , F , Tonelli , F , Holton , J L , Winglok Ho , P , Ho , S-L , Chou , M-Y , Polinski , N K , Martinez , T N , Davies , P & Alessi , D R 2018 , ' Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase ' , Biochemical Journal , vol. 475 , no. 1 , pp. 1-22 . https://doi.org/10.1042/BCJ20170802Test

مصطلحات موضوعية: Amino Acid Sequence, Animals, Antibodies, Monoclonal/biosynthesis, Phospho-Specific/biosynthesis, Antibody Specificity, Gene Expression Regulation, Genetic Predisposition to Disease, Gyrus Cinguli/enzymology, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Mice, Multigene Family, Mutation, Parkinson Disease/enzymology, Phosphorylation, Protein Isoforms/chemistry, Rabbits, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, rab GTP-Binding Proteins/chemistry, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/3f0c3737-39c4-4624-ac40-e5157c428299Test

الإتاحة: https://doi.org/10.1042/BCJ20170802Test
https://discovery.dundee.ac.uk/en/publications/3f0c3737-39c4-4624-ac40-e5157c428299Test
https://discovery.dundee.ac.uk/ws/files/19932333/1.full.pdfTest
http://www.scopus.com/inward/record.url?scp=85036568749&partnerID=8YFLogxKTest

المساهمون: College of Medicine, Dept. of Neurology, Jeong Hoon Hong, Yue Kyung Kim, Jae Seol Park, Ji Eun Lee, Mi Sun Oh, Eun Joo Chung, Jeong-Yeon Kim, Young-Hee Sung, Chul Hyoung Lyoo, Jae Hyeok Lee, Do-Young Kwon, Hyun Sook Kim, Hae-Won Shin, Sun Ah Park, In-Seok Park, Joong-Seok Kim, Phil Hyu Lee, Seong-Beom Koh, Jong Sam Baik, Sang Jin Kim, Hyeo-Il Ma, Jae Woo Kim, Yun Joong Kim, Lyoo, Chul Hyoung, Lee, Phil Hyu

مصطلحات موضوعية: Aged, Case-Control Studies, Cognitive Dysfunction/complications, Cognitive Dysfunction/genetics, Female, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Male, Middle Aged, Parkinson Disease/complications, Parkinson Disease/genetics, Polymorphism, Single Nucleotide, Republic of Korea, Cognitive impairment, Genetic risk factor, Idiopathic Parkinson�셲 disease, Leucine-rich repeat kinase 2

العلاقة: JOURNAL OF CLINICAL NEUROSCIENCE; J01328; OAK-2017-00575; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154060Test; http://www.sciencedirect.com/science/article/pii/S0967586816301229Test; T201700289; JOURNAL OF CLINICAL NEUROSCIENCE, Vol.36 : 108-113, 2017

الإتاحة: https://doi.org/10.1016/j.jocn.2016.10.013Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154060Test
http://www.sciencedirect.com/science/article/pii/S0967586816301229Test