التفاصيل البيبلوغرافية
| العنوان: |
Clinical description and outcome of overall varicella-zoster virus-related organ dysfunctions admitted in intensive care units: the VAZOREA cohort study |
| المؤلفون: |
Malherbe, J. (Jolan), Godard, P. (Pierre), Lacherade, J. (Jean-Claude), Coirier, V. (Valentin), Argaud, L. (Laurent), Hyvernat, H. (Hervé), Schneider, F. (Francis), Charpentier, J. (Julien), Wallet, F. (Florent), Pocquet, J. (Juliette), Plantefeve, G. (Gaëtan), Quenot, J. (Jean-Pierre), Bay, P. (Pierre), Delbove, A. (Agathe), Georges, H. (Hugues), Urbina, T. (Tomas), Schnell, D. (David), Le Moal, C. (Charlène), Stanowski, M. (Matthieu), Muris, C. (Corentin), Jonas, M. (Maud), Sauneuf, B. (Bertrand), Lesieur, O. (Olivier), Lhermitte, A. (Amaury), Calvet, L. (Laure), Gueguen, I. (Ines), du Cheyron, D. (Damien) |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Sciences du Vivant [q-bio]/Médecine humaine et pathologie |
| الوصف: |
Background: Due to aging population and increasing part of immunocompromised patients, a raise in life-threatening organ damage related to VZV can be expected. Two retrospective studies were already conducted on VZV in ICU but focused on specific organ injury. Patients with high-risk of VZV disease still must be identified. The objective of this study was to report the clinical features and outcome of all life-threatening VZV manifestations requiring intensive care unit (ICU) admission. This retrospective cohort study was conducted in 26 French ICUs and included all adult patients with any life-threatening VZV-related event requiring ICU admission or occurring in ICU between 2010 and 2019. Results: One-hundred nineteen patients were included with a median SOFA score of 6. One hundred eight patients (90.8%) were admitted in ICU for VZV disease, leaving 11 (9.2%) with VZV disease occurring in ICU. Sixty-one patients (51.3%) were immunocompromised. Encephalitis was the most prominent organ involvement (55.5%), followed by pneumonia (44.5%) and hepatitis (9.2%). Fifty-four patients (45.4%) received norepinephrine, 72 (60.5% of the total cohort) needed invasive mechanical ventilation, and 31 (26.3%) received renal-replacement therapy. In-hospital mortality was 36.1% and was significantly associated with three independent risk factors by multivariable logistic regression: immunosuppression, VZV disease occurring in ICU and alcohol abuse. Hierarchical clustering on principal components revealed five phenotypically distinct clusters of patients: VZV-related pneumonia, mild encephalitis, severe encephalitis in solid organ transplant recipients, encephalitis in other immunocompromised hosts and VZV disease occurring in ICU. In-hospital mortality was highly different across phenotypes, ranging from zero to 75% (p < 0.001). Conclusion: Overall, severe VZV manifestations are associated with high mortality in the ICU, which appears to be driven by immunosuppression status rather than any specific organ involvement. ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s13613-024-01270-w |
| حقوق: |
Paternité [CC] [BY] ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.D069E0A3 |
| قاعدة البيانات: |
BASE |
