World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy: a systematic review and meta-analysis
| العنوان: | World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy: a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Celso De la Cruz-Luque, Maria Lazo-Porras, Jose Carlos Tapia, Patricia Barrionuevo, Germán Málaga, Larry J. Prokop, Cesar Ugarte-Gil, Juan Pablo Domecq, Gabriela Prutsky, Ana Acuna-Villaorduna, Oscar J. Ponce |
| المصدر: | BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-14 (2020) Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona BMC Infectious Diseases Recercat. Dipósit de la Recerca de Catalunya instname |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Ofloxacin, Leprostatic Agents, Minocycline, law.invention, 030207 dermatology & venereal diseases, 0302 clinical medicine, Medical microbiology, Randomized controlled trial, Clinical Protocols, law, Recurrence, Treatment Failure, Child, Mycobacterium leprae/drug effects/isolation & purification, Neglected Diseases, Middle Aged, Mycobacterium leprae, Drug Therapy, Combination/adverse effects, Infectious Diseases, Rifampin/adverse effects/therapeutic use, Meta-analysis, Leprosy, Multibacillary, Leprosy, Multibacillary/drug therapy, Drug Therapy, Combination, Female, Leprosy, Rifampin, Research Article, Adult, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Leprostatic Agents/adverse effects/therapeutic use, purl.org/pe-repo/ocde/ford#3.03.08 [https], World Health Organization, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, Internal medicine, Leprosy, Paucibacillary/drug therapy, medicine, Humans, lcsh:RC109-216, Minocycline/adverse effects/therapeutic use, Aged, business.industry, Neglected Diseases/drug therapy, medicine.disease, Confidence interval, Treatment, Regimen, Relative risk, Systematic review, Observational study, Leprosy, Paucibacillary, business, Ofloxacin/adverse effects/therapeutic use |
| الوصف: | Background To evaluate the effectiveness and safety of the World Health Organization antibiotic regimen for the treatment of paucibacillary (PB) and multibacillary (MB) leprosy compared to other available regimens. Methods We performed a search from 1982 to July 2018 without language restriction. We included randomized controlled trials, quasi-randomized trials, and comparative observational studies (cohorts and case-control studies) that enrolled patients of any age with PB or MB leprosy that were treated with any of the leprosy antibiotic regimens established by the WHO in 1982 and used any other antimicrobial regimen as a controller. Primary efficacy outcomes included: complete clinical cure, clinical improvement of the lesions, relapse rate, treatment failure. Data were pooled using a random effects model to estimate the treatment effects reported as relative risk (RR) with 95% confidence intervals (CI). Results We found 25 eligible studies, 11 evaluated patients with paucibacillary leprosy, while 13 evaluated patients with MB leprosy and 1 evaluated patients of both groups. Diverse regimen treatments and outcomes were studied. Complete cure at 6 months of multidrug therapy (MDT) in comparison to rifampin-ofloxacin-minocycline (ROM) found RR of 1.06 (95% CI 0.88–1.27) in five studies. Whereas six studies compare the same outcome at different follow up periods between 6 months and 5 years, according to the analysis ROM was not better than MDT (RR of 1.01 (95% CI 0.78–1.31)) in PB leprosy. Conclusion Not better treatment than the implemented by the WHO was found. Diverse outcome and treatment regimens were studied, more statements to standardized the measurements of outcomes are needed. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c655cde1ef2b0cef3375827152d94557Test https://hdl.handle.net/20.500.12866/8323Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c655cde1ef2b0cef3375827152d94557 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |