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1
المؤلفون: Neil Moss, Lee Fader, Jeremy R Richman, Stanley Kugler, Matthew A. Cerny, Jennifer Burke, Raquel Arenas, Derek Cogan, Federico Colombo, Maolin Yu, Kosea Frederick, John Lord, Zhidong Chen, Jean-Huges Parmentier, Balestra Michael, Nicholas F. Brown, Steven M. Weldon, Xin Guo, Daniel R. Goldberg, Michael Zhang, Holly Clifford, Jennifer Schmenk, Kenneth M. Meyers, Daniel Richard Marshall, Keith R Hornberger
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:979-984
مصطلحات موضوعية: 0301 basic medicine, Aldosterone synthase, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Cytochrome P-450 CYP11B2, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Aldosterone, Dose-Response Relationship, Drug, Molecular Structure, ATP synthase, biology, Organic Chemistry, Isoxazoles, Metabolism, In vitro, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Hepatocyte, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b0efa78c0594d187a77fbd86938a66Test
https://doi.org/10.1016/j.bmcl.2017.12.015Test -
2
المؤلفون: Steven R. LaPlante, René Coulombe, Thao Trinh, Dominik Wernic, Rebekah J. Carson, Nathalie Rioux, Bruno Simoneau, Catherine Chabot, Youla S. Tsantrizos, Jianmin Duan, Simon Surprenant, Pierre R. Bonneau, Carl Thibeault, Stephen W. Mason, Serge Landry, Craig Fenwick, François Bilodeau, Araz Jakalian, Murray D. Bailey, Stephen H. Kawai, Clint James, Yves Bousquet, Bounkham Thavonekham, Michel Garneau, Eric Beaulieu, Sébastien Morin, Christiane Yoakim, Ted Halmos, Lee Fader, Jennifer Tsoung
المصدر: ACS Medicinal Chemistry Letters. 7:797-801
مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Organic Chemistry, Integrase inhibitor, Biology, Pharmacology, 01 natural sciences, Biochemistry, Desymmetrization, Virus, Chemical space, 0104 chemical sciences, Integrase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Pharmacokinetics, chemistry, Drug Discovery, Pyridine, biology.protein, Potency
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88190548f46d19bc513630aa18caccdTest
https://doi.org/10.1021/acsmedchemlett.6b00194Test -
3
المؤلفون: Thao Trinh, James Gillard, Clint James, Martin Duplessis, Laibin Luo, Michael Franti, Carl Thibeault, Marc-André Joly, Jessica Desjardins, Martine Brault, Claudio Sturino, Montse Llinas-Brunet, Sébastien Morin, Sonia Tremblay, Mathieu Parisien, Louie Lamorte, Josée Bordeleau, Cyrille Kuhn, François Bilodeau, Maude Poirier, Sanjay Srivastava, Christiane Yoakim, Nathalie Dansereau, James L. Gleason, Lee Fader, Vida Gorys, Louis Morency
المصدر: ACS Medicinal Chemistry Letters. 7:525-530
مصطلحات موضوعية: 0301 basic medicine, Human cytomegalovirus, 030102 biochemistry & molecular biology, Organic Chemistry, Biology, Pharmacology, medicine.disease, Biochemistry, Virology, Virus, Bioavailability, 03 medical and health sciences, 030104 developmental biology, Mechanism of action, Viral life cycle, Viral replication, Pharmacokinetics, Drug Discovery, medicine, Potency, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee1e021d799cff1bd9fa128c1ad3428Test
https://doi.org/10.1021/acsmedchemlett.6b00064Test -
4
المؤلفون: Félix Chagnon, Lee Fader, Dorich Stéphane, Bin Chen, Jason Burch, St-Onge Miguel, Serge Leger, Jennifer H. Cox
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127104
مصطلحات موضوعية: Prostaglandin E receptor 3, 010405 organic chemistry, Chemistry, Stereochemistry, Prostaglandin E2 receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Allylic alcohol, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Discovery, Molecular Medicine, lipids (amino acids, peptides, and proteins), Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::78b12514f128099ac69f690481a8d164Test
https://doi.org/10.1016/j.bmcl.2020.127104Test -
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المؤلفون: Gérard Cahiez, Mouâd Alami, Richard J. K. Taylor, Mark Reid, Jonathan S. Foot, Lee Fader, Vikas Sikervar, Jagadish Pabba
مصطلحات موضوعية: 010405 organic chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ce3c7906bb99a7eb2d3eb5ceae6bc41aTest
https://doi.org/10.1002/047084289x.rm021.pub4Test -
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المؤلفون: Nathalie Rioux, Sonia Tremblay, Michel Garneau, Pierre R. Bonneau, René Coulombe, Marc-André Poupart, Bruno Simoneau, Steve Mason, Louie Lamorte, Patricia Schroeder, Stephen H. Kawai, Jianmin Duan, Ma’an Amad, Laibin Luo, Lee Fader, Anne-Marie Faucher, Steven R. LaPlante, Craig Fenwick, Araz Jakalian, Michael Bös, Youla S. Tsantrizos, Paul J. Edwards, Myriam Witvrouw, Murray D. Bailey, Michael G. Cordingley, Richard Bethell, Christiane Yoakim
المصدر: Antimicrobial Agents and Chemotherapy. 58:3233-3244
مصطلحات موضوعية: Serum, Anti-HIV Agents, Stereochemistry, Integrase inhibitor, HIV Integrase, Virus Replication, Antiviral Agents, Mice, Pharmacokinetics, Drug Resistance, Viral, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), HIV Integrase Inhibitors, Cloning, Molecular, ADME, Pharmacology, chemistry.chemical_classification, biology, Cytochrome P450, Molecular biology, Long terminal repeat, Rats, Integrase, Bioavailability, Infectious Diseases, Enzyme, Amino Acid Substitution, chemistry, DNA, Viral, HIV-1, Hepatocytes, biology.protein, Caco-2 Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1eee31c986fed387f5f7398f1e29bb1Test
https://doi.org/10.1128/aac.02719-13Test -
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المؤلفون: Murray D. Bailey, Rebekah J. Carson, Michel Garneau, François Bilodeau, Jianmin Duan, Stephen H. Kawai, Steven R. LaPlante, Christiane Yoakim, Araz Jakalian, René Coulombe, Sébastien Morin, Kevork Mekhssian, Catherine Chabot, Bruno Simoneau, Lee Fader, Youla S. Tsantrizos, Ted Halmos, Craig Fenwick, Stephen W. Mason
المصدر: ACS Medicinal Chemistry Letters. 5:711-716
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Quinoline, Integrase inhibitor, Biology, Biochemistry, In vitro, Integrase, Amino acid, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, Lead compound, ADME
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791d4ac3a5a2479fb5fbf67984413c62Test
https://doi.org/10.1021/ml500110jTest -
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المؤلفون: Marc Pesant, Christian Brochu, Rebekah J. Carson, Bruno Simoneau, Patricia Schroeder, Murray D. Bailey, Pierre R. Bonneau, Michael G. Cordingley, Catherine Chabot, Michel Garneau, Anne-Marie Faucher, Michael Bös, René Coulombe, Mathieu Parisien, Stephen W. Mason, Araz Jakalian, Jianmin Duan, Marc-André Poupart, Dominik Wernic, Sébastien Morin, François Bilodeau, Serge Landry, Yves Bousquet, Eric Malenfant, Stephen H. Kawai, Punit Bhardwaj, Ma’an Amad, Lee Fader, Youla S. Tsantrizos, Richard Bethell, Christiane Yoakim, Steven R. LaPlante, Paul J. Edwards, Ted Halmos, Craig Fenwick
المصدر: ACS Medicinal Chemistry Letters. 5:422-427
مصطلحات موضوعية: biology, Organic Chemistry, Quinoline, Allosteric regulation, Substituent, Human immunodeficiency virus (HIV), Integrase inhibitor, Metabolic stability, medicine.disease_cause, Biochemistry, Combinatorial chemistry, Integrase, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, biology.protein, Potency
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bbe9a8b0f8d3640b1a6a0a1c772694Test
https://doi.org/10.1021/ml500002nTest -
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المؤلفون: Stephen W. Mason, Bruno Simoneau, Oliver Hucke, Sébastien Morin, Yves Bousquet, Jianmin Duan, Steve Titolo, Serge Landry, Isabelle Dion, Michel Garneau, Christopher T. Lemke, Pierre R. Bonneau, Lee Fader, Stephen H. Kawai, Sylvie Goulet, Nathalie Goudreau, Jean Rancourt, Ma’an Amad
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3401-3405
مصطلحات موضوعية: Cell Membrane Permeability, Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Stereocenter, Benzodiazepines, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Moiety, Molecular Biology, Benzodiazepinones, Binding Sites, Chemistry, Virus Assembly, Organic Chemistry, Stereoisomerism, Protein Structure, Tertiary, Diazepine, Capsid, HIV-1, Molecular Medicine, Capsid Proteins, Caco-2 Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ffc2f6d374e474188c249abe14b2cdTest
https://doi.org/10.1016/j.bmcl.2013.03.074Test -
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المؤلفون: Anne-Marie Faucher, Bruno Simoneau, Yves Bousquet, Christopher T. Lemke, Jean‐François Mercier, Steve Titolo, Lee Fader, Eric Malenfant, Stephen W. Mason, Nathalie Goudreau, Chantal Grand-Maître, Jean-Eric Lacoste, René Coulombe
المصدر: ChemMedChem. 8:405-414
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, medicine.drug_class, Crystallography, X-Ray, Ligands, Biochemistry, Benzodiazepines, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Binding selectivity, Pharmacology, Benzodiazepine, Binding Sites, Nitrogen Isotopes, Chemistry, Drug discovery, Organic Chemistry, Fluorine, Nuclear magnetic resonance spectroscopy, Ligand (biochemistry), In vitro, Protein Structure, Tertiary, Capsid, HIV-1, Molecular Medicine, Capsid Proteins, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb86608a77792ad9b94488c033798ccfTest
https://doi.org/10.1002/cmdc.201200580Test