دورية أكاديمية
Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility
| العنوان: | Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility |
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| المؤلفون: | Martin Mena, Anthony, Négrier, Laura, Treizebre, A., Guilbert, Marie, Bonnaire, Lucille, Daniau, Valentine, Leba Bonki, Gabie, Odou, Pascal, Genay, Stéphanie, Décaudin, Bertrand |
| المساهمون: | Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Bio-Micro-Electro-Mechanical Systems - IEMN (BIOMEMS - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), This work was funded by the French government (through the Contrat de Plan Etat-Région TECSANTE 2021–2027 program) and the French National Centre for Scientific Research (through the Renatech network of nanotechnology facilities)., Renatech Network, CMNF |
| المصدر: | ISSN: 1999-4923 ; Pharmaceutics ; https://hal.science/hal-04196721Test ; Pharmaceutics, 2023, Advances in Parenteral Formulations, 15 (8), pp.2069. ⟨10.3390/pharmaceutics15082069⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Université Polytechnique Hauts-de-France: HAL |
| مصطلحات موضوعية: | drug incompatibility, in-line filter, infusion, particulate load, piperacillin/tazobactam, vancomycin, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Background: Drug incompatibility is defined as a physical-chemical reaction between two or more injectable drugs and that results mainly in precipitation or insolubility. Several strategies for reducing incompatibilities have been implemented empirically in intensive care units. However, these strategies have never been compared directly (and particularly in terms of the particulate load and drug mass flow rate) under standardized conditions. The objective of the present in vitro study was to evaluate the impact of various strategies for preventing incompatibility between simultaneously infused vancomycin and piperacillin/tazobactam.Methods: An in-line filter, a dilute vancomycin solution (5 mg/mL), and an alternative saline administration line were evaluated separately. The infusion line outlet was connected to a dynamic particle counter. The antibiotic concentration was measured in an HPLC-UV assay.Result: The use of an in-line filter and an alternative saline administration route did not significantly reduce the particulate load caused by vancomycin-piperacillin/tazobactam incompatibility. Dilution of the vancomycin solution was associated with a significantly lower particulate load and maintenance of the vancomycin mass flow rate.Discussion: It is important to systematically compare the efficacy of strategies for preventing drug incompatibility. The use of diluted vancomycin solution gave the best results in the case of vancomycin-piperacillin/tazobactam incompatibility. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37631283; hal-04196721; https://hal.science/hal-04196721Test; https://hal.science/hal-04196721/documentTest; https://hal.science/hal-04196721/file/AnthonyMartinMena_pharmaceutics-15-02069_2023.pdfTest; PUBMED: 37631283; PUBMEDCENTRAL: PMC10459903 |
| DOI: | 10.3390/pharmaceutics15082069 |
| الإتاحة: | https://doi.org/10.3390/pharmaceutics15082069Test https://hal.science/hal-04196721Test https://hal.science/hal-04196721/documentTest https://hal.science/hal-04196721/file/AnthonyMartinMena_pharmaceutics-15-02069_2023.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8CA83B9E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pharmaceutics15082069 |
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