المؤلفون: Kapil Gadkar, Christina Friedrich, Vincent Hurez, Maria‐Luisa Ruiz, Leslie Dickmann, Mohit Kumar Jolly, Leah Schutt, Jin Jin, Joseph A. Ware, Saroja Ramanujan

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 616-627 (2022)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2163-8306Test

الوصول الحر: https://doaj.org/article/4d3f8999655d4cd4aa9f1a6f87ba8b9eTest

المؤلفون: Leah Schutt, Leslie J. Dickmann, Vincent Jacques Hurez, Kapil Gadkar, Christina M. Friedrich, Saroja Ramanujan, Maria-Luisa Ruiz, Jin Jin, Mohit Kumar Jolly, Joseph A. Ware

المصدر: CPT: Pharmacometrics & Systems Pharmacology. 11:616-627

مصطلحات موضوعية: Diarrhea, education.field_of_study, Kinase, business.industry, Population, Network Pharmacology, Pharmacology, Colitis, medicine.disease, Phosphatidylinositol 3-Kinases, Modeling and Simulation, Humans, Protein Isoforms, Medicine, Pharmacology (medical), medicine.symptom, education, Idelalisib, business, Adverse effect, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Systems pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ea4f9d5d566d37debe0d925fb55c1dTest
https://doi.org/10.1002/psp4.12749Test

المؤلفون: Shumei Wang, Jodie Pang, Heidi J.A. Wallweber, Leah Schutt, Michael Siu, Steven T. Staben, Christopher J. Sneeringer, Yunli Wang, Aditya Murthy, Dennis X. Hu, Yoana N. Dimitrova, Madeleine S. Prangley, Grace Ka Yan Chan, Erin McNamara, Laurent Salphati, Haochu Huang, Huifen Chen, Yong Chen, Snahel Patel, Kai C. Wu, Wensheng Zhao, John Moffat, Junghyun Lim, Joanna Y. Lee

المصدر: Journal of medicinal chemistry. 65(17)

مصطلحات موضوعية: Chemistry, Endosome, Kinase, fungi, Antineoplastic Agents, Endosomes, Pharmacology, Class III Phosphatidylinositol 3-Kinases, Bioavailability, Residue (chemistry), In vivo, Drug Discovery, Autophagy, Molecular Medicine, Potency, Structure based, Kinase activity, Phosphatidylinositol 3-Kinase, Phosphorylation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36afbb3b9cf259ab9526b62e50db3e7Test
https://pubmed.ncbi.nlm.nih.gov/34779204Test

المؤلفون: Cleopatra Kozlowski, Leah Schutt, Noel Dybdal, Melissa Schutten, Karen S. Regan, Fangyao Hu

المصدر: Toxicologic Pathology. 48:350-361

مصطلحات موضوعية: endocrine system, H&E stain, Toxicology, Bioinformatics, 030218 nuclear medicine & medical imaging, Pathology and Forensic Medicine, Rats, Sprague-Dawley, 03 medical and health sciences, Deep Learning, 0302 clinical medicine, Corpus Luteum, Image Processing, Computer-Assisted, Animals, Medicine, Molecular Biology, Retrospective Studies, business.industry, Digital pathology, Cancer, Cell Biology, Gold standard (test), Ovarian toxicity, medicine.disease, Rats, Pre-clinical development, 030220 oncology & carcinogenesis, Toxicity, Female, business, Reproductive toxicity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84c9c8a8cefa57af0656042665a04a1Test
https://doi.org/10.1177/0192623319877871Test

المؤلفون: Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini

المصدر: Journal of medicinal chemistry. 64(16)

مصطلحات موضوعية: Phases of clinical research, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, Breast cancer, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Dosing, Molecular Structure, Chemistry, Antagonist, Estrogen Receptor alpha, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, Macaca fascicularis, Cell culture, Cancer research, MCF-7 Cells, Molecular Medicine, Female, Estrogen Receptor Antagonists, Carbolines

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710Test
https://pubmed.ncbi.nlm.nih.gov/34251202Test

المؤلفون: Pai, Rama, French, Dorothy, Ma, Ning, Hotzel, Kathy, Plise, Emile, Salphati, Laurent, Setchell, Kenneth D. R., Ware, Joseph, Lauriault, Veronique, Leah, Schutt, Hartley, Dylan, Dambach, Donna

مصطلحات موضوعية: Molecular Toxicology

وصف الملف: text/html

العلاقة: http://toxsci.oxfordjournals.org/cgi/content/short/kfs011v1Test; http://dx.doi.org/10.1093/toxsci/kfs011Test

الإتاحة: https://doi.org/10.1093/toxsci/kfs011Test
http://toxsci.oxfordjournals.org/cgi/content/short/kfs011v1Test

المؤلفون: Le An, Jonathan Maher, Yingqing Ran, Ryan E. Morgan, Lisa Wong, Laurent Salphati, Leah Schutt, Xiaolin Zhang, David Potter, Steven Cepa, Jacqueline M. Tarrant, Jodie Pang, Roxanne Andaya

المصدر: Toxicology and Applied Pharmacology. 338:204-213

مصطلحات موضوعية: Male, 0301 basic medicine, Drug, medicine.medical_specialty, medicine.drug_class, media_common.quotation_subject, Toxicology, Risk Assessment, Bile Acids and Salts, Rats, Sprague-Dawley, Troglitazone, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Animals, Chromans, ATP Binding Cassette Transporter, Subfamily B, Member 11, media_common, Pharmacology, Liver injury, Bile acid, business.industry, Taurocholic acid, medicine.disease, Bile Salt Export Pump, Rats, 030104 developmental biology, Endocrinology, chemistry, Toxicity, Female, Thiazolidinediones, Chemical and Drug Induced Liver Injury, business, Homeostasis, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8004fdf2e2913eead1e9740f774a2c2bTest
https://doi.org/10.1016/j.taap.2017.11.007Test

المؤلفون: Tom Gelzleichter, Lisa P. Wong, Leah Schutt, Dale Stevens

المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595

مصطلحات موضوعية: Pharmacology, business.industry, REPEAT DOSE TOXICITY, Telemetry, Medicine, Toxicology, Bioinformatics, business, Small molecule, Animal use

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1339bbfc47ba336a3ac0cefde195aa53Test
https://doi.org/10.1016/j.vascn.2019.05.157Test

المؤلفون: Daniel F. Ortwine, Rebecca Erickson, Jonathan Hau, Binqing Wei, Charles Eigenbrot, Arna Katewa, James J. Crawford, Regina Choy, Dinah Misner, Georgette Castanedo, Pawan Bir Kohli, Suzanne Tay, Liming Dong, Lisa D. Belmont, Joseph W. Lubach, Wendy B. Young, Adam R. Johnson, Lichuan Liu, Harvey Wong, Leah Schutt, Karin Reif, Brent S. McKenzie, Melis Coraggio, Nico Ghilardi, Wendy Lee

المصدر: Journal of medicinal chemistry. 61(6)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Pyridones, Inflammatory arthritis, Anti-Inflammatory Agents, Arthritis, Piperazines, Madin Darby Canine Kidney Cells, Arthritis, Rheumatoid, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, immune system diseases, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Lupus Erythematosus, Systemic, Protein Kinase Inhibitors, B cell, Systemic lupus erythematosus, Lupus erythematosus, biology, Molecular Structure, Chemistry, medicine.disease, Arthritis, Experimental, Rats, 030104 developmental biology, medicine.anatomical_structure, Rats, Inbred Lew, Rheumatoid arthritis, biology.protein, Cancer research, Molecular Medicine, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171fe4766ddac8a0a9256be7fc563e0cTest
https://pubmed.ncbi.nlm.nih.gov/29457982Test

المؤلفون: Wendy B. Young, Karin Reif, Jed Ross, Jacqueline M. Tarrant, Donna M. Dambach, Karin Staflin, Adam R. Johnson, Arna Katewa, Rebecca Erickson, Maj Hedehus, Shelly Zhong, Sock-Cheng Lewin-Koh, Fiona Zhong, Lichuan Liu, Michelle McDowell, James J. Crawford, Dinah L. Misner, Richard A. D. Carano, Harvey Wong, Leah Schutt

المصدر: The Journal of pharmacology and experimental therapeutics. 360(1)

مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Myeloid, Pyridones, Inflammation, Biology, Gene Expression Regulation, Enzymologic, Piperazines, 03 medical and health sciences, Mice, Dogs, Species Specificity, Fibrosis, medicine, Acinar cell, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Glucose homeostasis, Animals, Humans, Pyrroles, Pancreas, Protein Kinase Inhibitors, Pharmacology, Dose-Response Relationship, Drug, Protein-Tyrosine Kinases, medicine.disease, Rats, 030104 developmental biology, medicine.anatomical_structure, Glucose, Rheumatoid arthritis, biology.protein, Cancer research, Molecular Medicine, Female, medicine.symptom, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c52d1f7eef877b23d6153cf3a1c3f8Test
https://pubmed.ncbi.nlm.nih.gov/27821712Test