Advanced glycation end products as predictors of renal function in youth with type 1 diabetes

التفاصيل البيبلوغرافية
العنوان:	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
المؤلفون:	Forbes, J.M., Le Bagge, S., Righi, S., Fotheringham, A.K., Gallo, L.A., McCarthy, D.A., Leung, S., Baskerville, T., Nisbett, J., Morton, A., Teasdale, S., D’Silva, N., Barrett, H., Jones, T., Couper, J., Donaghue, K., Isbel, N., Johnson, D.W., Donnellan, L., Deo, P.
المصدر:	http://dx.doi.org/10.1038/s41598-021-88786-4Test.
بيانات النشر:	Springer Science and Business Media
سنة النشر:	2021
المجموعة:	The University of Adelaide: Digital Library
مصطلحات موضوعية:	Kidney, Skin, Humans, Kidney Diseases, Diabetes Mellitus, Type 1, Blood Glucose, Glomerular Filtration Rate, Risk, Adolescent, Adult, Female, Male, Young Adult, Optical Imaging, Glycation End Products, Advanced, Glycated Hemoglobin, Glycated Hemoglobin A
الوصف:	To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m 2 ) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m 2 ) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFR CKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10 -12 ). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10 -9 ), which increased with diabetes duration (51%; P model < 2.2 × 10 -16 ) and random blood glucose concentrations (56%; P model < 2.2 × 10 -16 ). HbA 1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes. ; Josephine M. Forbes, Selena Le Bagge, Samuel Righi, Amelia K. Fotheringham, Linda A. Gallo, Domenica A. McCarthy . et al.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	2045-2322
العلاقة:	http://purl.org/au-research/grants/nhmrc/1102935Test; http://purl.org/au-research/grants/nhmrc/1160428Test; Scientific Reports, 2021; 11(1):9422-1-9422-10; https://hdl.handle.net/2440/133708Test; Couper, J. [0000-0003-4448-8629]
DOI:	10.1038/s41598-021-88786-4
الإتاحة:	https://doi.org/10.1038/s41598-021-88786-4Test https://hdl.handle.net/2440/133708Test
حقوق:	© Te Author(s) 2021. Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/.
رقم الانضمام:	edsbas.33C85DE9
قاعدة البيانات:	BASE

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تدمد:	20452322
DOI:	10.1038/s41598-021-88786-4