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1دورية أكاديمية
المؤلفون: Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu
المصدر: Pharmaceutics, Vol 14, Iss 11, p 2385 (2022)
مصطلحات موضوعية: JAK inhibitors, colonic drug delivery, drug stability, ulcerative colitis, Crohn’s disease, anti-inflammatory, Pharmacy and materia medica, RS1-441
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J. Piers, Gretchen A. Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G. Hegde, Xiao Hu, Laura L. Carter, Thomas D. Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C. Correll, Dallas C. Jones, Daniel J. Cua
المصدر: Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
مصطلحات موضوعية: RORγT, small-molecule antagonist, thymopoiesis, T cell repertoire, autoimmunity, experimental autoimmune encephalomyelitis, experimental psoriasis, Biology (General), QH301-705.5
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124716316473Test; https://doaj.org/toc/2211-1247Test
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3دورية أكاديمية
المؤلفون: Mitchell H. Keylor (8615976), Anmol Gulati (1314951), Solomon D. Kattar (11888244), Rebecca E. Johnson (1361724), Ryan W. Chau (11888247), Kaila A. Margrey (1849126), Michael J. Ardolino (2154361), Cayetana Zarate (1516576), Kelsey E. Poremba (3903853), Vladimir Simov (2534833), Gregori J. Morriello (2645770), John J. Acton (11888250), Barbara Pio (1601539), Xin Yan (17064), Rachel L. Palte (8299626), Spencer E. McMinn (9931798), Lisa Nogle (2160265), Charles A. Lesburg (1834624), Donovon Adpressa (8448369), Shishi Lin (752964), Santhosh Neelamkavil (2679916), Ping Liu (156158), Jing Su (23377), Laxminarayan G. Hegde (2480896), Janice D. Woodhouse (8299629), Robert Faltus (11888253), Tina Xiong (6095357), Paul J. Ciaccio (11888256), Jennifer Piesvaux (5987792), Karin M. Otte (2459014), Harold B. Wood (1665394), Matthew E. Kennedy (2026285), David Jonathan Bennett (7456754), Erin F. DiMauro (797168), Matthew J. Fell (3839692), Peter H. Fuller (2400580)
مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Evolutionary Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, stereochemical design elements, hydrogen bond donor, friendly profile typified, central nervous system, selective lrrk2 inhibitors, encouraging brain penetration, 22 b, structural enablement, rigorous hit, quality molecules, preclinical models, pd ), parkinson ’, mediated efflux, low levels, functionally linked, enhancing increase
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المؤلفون: David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
المصدر: Journal of Medicinal Chemistry. 65:16801-16817
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726Test
https://doi.org/10.1021/acs.jmedchem.2c01605Test -
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المؤلفون: Frederique M. Poulet, J. Michael Ellis, Matthew E. Kennedy, Carrie G. Markgraf, Lauren M Timmins, Dianne K. Bryce, Sabu Kuruvilla, Janice D Woodhouse, Matthew J. Fell, Karin M. Otte, Christopher Ware, Laxminarayan G Hegde, Matthew L. Maddess, Paul J Ciaccio
المصدر: Journal of Pharmacology and Experimental Therapeutics. 377:11-19
مصطلحات موضوعية: Male, 0301 basic medicine, Indazoles, Parkinson's disease, Morpholines, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Animals, Kinase activity, Protein Kinase Inhibitors, Lung, Kinase, business.industry, medicine.disease, Pulmonary Surfactant-Associated Protein C, LRRK2, nervous system diseases, Mice, Inbred C57BL, Pyrimidines, 030104 developmental biology, medicine.anatomical_structure, Alveolar Epithelial Cells, Molecular Medicine, Immunohistochemistry, business, 030217 neurology & neurosurgery, Protein C, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f51a63a6fe69d40bfa5ed39544e2ddTest
https://doi.org/10.1124/jpet.120.000217Test -
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المؤلفون: Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca E. Johnson, Ryan W. Chau, Kaila A. Margrey, Michael J. Ardolino, Cayetana Zarate, Kelsey E. Poremba, Vladimir Simov, Gregori J. Morriello, John J. Acton, Barbara Pio, Xin Yan, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Charles A. Lesburg, Donovon Adpressa, Shishi Lin, Santhosh Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Harold B. Wood, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Peter H. Fuller
المصدر: Journal of medicinal chemistry. 65(1)
مصطلحات موضوعية: Antiparkinson Agents, Models, Molecular, Structure-Activity Relationship, Drug Design, Drug Discovery, Quinazolines, Molecular Medicine, Biological Availability, Brain, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6720c280fccf3e18653a864a196348adTest
https://pubmed.ncbi.nlm.nih.gov/34967623Test -
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المؤلفون: Matthew H. Daniels, Sunil Nagpal, Blair T. Lapointe, Jos Cals, Mario van der Stelt, Vladimir Simov, Willem Jan Karstens, Sujal V. Deshmukh, Kenneth Jay Barr, J. Richard Miller, Hans van Eenenaam, Craig C. Correll, John Maclean, Laxminarayan G Hegde, Lily Y. Moy, B. Wesley Trotter, Rachel L. Palte, Janice D Woodhouse, Nunzio Sciammetta, Gopal Parthasarathy, Heidi Ferguson, Rita Azevedo, Hongjun Zhang, Arthur Oubrie, Neville J. Anthony
المصدر: ACS Medicinal Chemistry Letters. 11:114-119
مصطلحات موضوعية: medicine.drug_class, Chemistry, Organic Chemistry, Allosteric regulation, Monoclonal antibody, Biochemistry, Combinatorial chemistry, Small molecule, chemistry.chemical_compound, Nuclear receptor, RAR-related orphan receptor gamma, Drug Discovery, medicine, Moiety, Piperidine, Benzoic acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a9a20903f38d39770d2e5897d3e47Test
https://doi.org/10.1021/acsmedchemlett.9b00431Test -
8Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
المؤلفون: Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio
المصدر: RSC Med Chem
مصطلحات موضوعية: Pharmacology, 0303 health sciences, Trifluoromethyl, Chemistry, Metabolite, Organic Chemistry, Pharmaceutical Science, Pyrazole, Leucine-rich repeat, Biochemistry, LRRK2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Kinome, Penetrant (biochemical), Linker, 030304 developmental biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afaTest
https://europepmc.org/articles/PMC8292993Test/ -
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المؤلفون: Hongjun, Zhang, Blair T, Lapointe, Neville, Anthony, Rita, Azevedo, Jos, Cals, Craig C, Correll, Matthew, Daniels, Sujal, Deshmukh, Hans, van Eenenaam, Heidi, Ferguson, Laxminarayan G, Hegde, Willem Jan, Karstens, John, Maclean, J Richard, Miller, Lily Y, Moy, Vladimir, Simov, Sunil, Nagpal, Arthur, Oubrie, Rachel L, Palte, Gopal, Parthasarathy, Nunzio, Sciammetta, Mario, van der Stelt, Janice D, Woodhouse, B Wesley, Trotter, Kenneth, Barr
المصدر: ACS Med Chem Lett
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b04108fd54b05ba3642d5229b4061176Test
https://pubmed.ncbi.nlm.nih.gov/32071676Test -
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المؤلفون: Laura Engstrom, Kyle J. Piers, Kenneth Jay Barr, Renu Jain, Dallas C. Jones, Huseyin Mehmet, Heidi Ferguson, Gary D. Glick, John S. Mudgett, Richard Miller, Xiao Hu, Hongjun Zhang, I-Ming Wang, Abbas Hawwari, Craig C. Correll, Barbara Joyce-Shaikh, Razvan Cristescu, Yanxia Guo, Daniel J. Cua, Gretchen A. Baltus, Yi Chen, Thomas Daniel Aicher, Dennis M. Zaller, Laura L. Carter, Laxminarayan G Hegde, Kenzie D. MacIsaac
المصدر: Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
مصطلحات موضوعية: 0301 basic medicine, T-cell receptor, small-molecule antagonist, autoimmunity, experimental autoimmune encephalomyelitis, Gene rearrangement, Biology, General Biochemistry, Genetics and Molecular Biology, Cell biology, 03 medical and health sciences, Thymocyte, 030104 developmental biology, lcsh:Biology (General), RAR-related orphan receptor gamma, thymopoiesis, Immunology, Transcriptional regulation, RORγT, Transcription factor, T cell repertoire, lcsh:QH301-705.5, CD8, Thymocyte migration, experimental psoriasis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0611f033ecc5354d2efdd17e30b783fTest
http://www.sciencedirect.com/science/article/pii/S2211124716316473Test