Inclusion of Anesthetics in Cyclodextrins: Structural Investigation of Solid Inclusion Complexes of Butamben
| العنوان: | Inclusion of Anesthetics in Cyclodextrins: Structural Investigation of Solid Inclusion Complexes of Butamben |
|---|---|
| المؤلفون: | Susan A. Bourne, Mino R. Caira, Sibulelo L. Vilakazi, Laveshni Reddy |
| المصدر: | Supramolecular Chemistry. 16:279-285 |
| بيانات النشر: | Informa UK Limited, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | chemistry.chemical_compound, Residue (chemistry), Crystallography, Microcrystalline, chemistry, Hydrogen bond, Molecule, Moiety, General Chemistry, Butamben, Single crystal, Monoclinic crystal system |
| الوصف: | Single crystal and powder X-ray diffraction techniques were used to characterize inclusion complexes formed between the local anesthetic butamben (4-aminobenzoic acid butyl ester) and various cyclodextrins (CDs). Kneading butamben with the native hosts β- and γ-CD yielded microcrystalline products, unequivocally identified as inclusion complexes by powder X-ray diffraction. Single crystals of a 1:1 inclusion complex between butamben and permethylated β-CD (TRIMEB) were isolated. X-ray analysis revealed that the guest is included with the ester moiety fully encapsulated in the TRIMEB cavity. However, a major part of the phenylamine residue protrudes from the host primary side, entering the secondary side of a translated TRIMEB molecule to which it hydrogen bonds, both directly [–NHA O(host)] and indirectly [–NHB O(water) O(host)]. This unusual mode of guest inclusion is associated with a novel channel-like complex packing arrangement in the monoclinic space group P21. The included drug molecule adopts a... |
| تدمد: | 1029-0478 1061-0278 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9e15d6a96b7f11f26bd33bce10276cf6Test https://doi.org/10.1080/1061027042000204038Test |
| رقم الانضمام: | edsair.doi...........9e15d6a96b7f11f26bd33bce10276cf6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10290478 10610278 |
|---|