المؤلفون: Magali Saez-Ayala, Laurent Hoffer, Sébastien Abel, Khaoula Ben Yaala, Benoit Sicard, Guillaume P. Andrieu, Mehdi Latiri, Emma K. Davison, Marco A. Ciufolini, Paul Brémond, Etienne Rebuffet, Philippe Roche, Carine Derviaux, Edwige Voisset, Camille Montersino, Remy Castellano, Yves Collette, Vahid Asnafi, Stéphane Betzi, Patrice Dubreuil, Sébastien Combes, Xavier Morelli

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/455ce64ed58b44c582373ae5edcfa6e5Test

المؤلفون: Hamza Olleik, Taher Yacoub, Laurent Hoffer, Senankpon Martial Gnansounou, Kehna Benhaiem-Henry, Cendrine Nicoletti, Malika Mekhalfi, Valérie Pique, Josette Perrier, Akram Hijazi, Elias Baydoun, Josette Raymond, Philippe Piccerelle, Marc Maresca, Maxime Robin

المصدر: Antibiotics, Vol 9, Iss 7, p 381 (2020)

مصطلحات موضوعية: berberine derivatives, anti-bacterial agents, microbial sensitivity tests, structure-activity relationship, resistant strain, FtsZ protein, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2079-6382/9/7/381Test; https://doaj.org/toc/2079-6382Test

الوصول الحر: https://doaj.org/article/5b7d19f291ad45049c83926b5ed75c41Test

المؤلفون: Laurent Hoffer, Camelia Chira, Gilles Marcou, Alexandre Varnek, Dragos Horvath

المصدر: Molecules, Vol 20, Iss 5, Pp 8997-9028 (2015)

مصطلحات موضوعية: genetic algorithms, conformational sampling, docking, interaction fingerprints, force field fitting, Organic chemistry, QD241-441

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/1420-3049/20/5/8997Test; https://doaj.org/toc/1420-3049Test

الوصول الحر: https://doaj.org/article/7c75a801591c481ba4354655cc3f5b6dTest

المؤلفون: Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi

المصدر: Journal of Medicinal Chemistry. 66:5041-5060

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::87d2380cfc1eda17d3f8edf2cae4eb67Test
https://doi.org/10.1021/acs.jmedchem.2c02132Test

المؤلفون: Laurent Hoffer, Manon Garcia, Raphael Leblanc, Mikael Feracci, Stéphane Betzi, Khaoula Ben Yaala, Avais M. Daulat, Pascale Zimmermann, Philippe Roche, Karine Barral, Xavier Morelli

المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-18-CE13-0017,SynTEV,Rôle des réseaux tétraspanines-syndécanes-PDZ dans l'hétérogénéité moléculaire et fonctionelle des vésicules extracellulaires(2018), ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01569⟩

مصطلحات موضوعية: Inhibitors, [SDV]Life Sciences [q-bio], Organic compounds, Drug Discovery, Binding modes, Reaction products, Molecular Medicine, Alkyls

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02c587bd9724eeb81ed64891ae923d8Test
https://doi.org/10.1021/acs.jmedchem.2c01569Test

المؤلفون: Laetitia Ganier, Stephane Betzi, Carine Derviaux, Philippe Roche, Charlotte Dessaux, Christophe Muller, Laurent Hoffer, Xavier Morelli, Jean-Paul Borg

المساهمون: Betzi, Stéphane, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)

المصدر: ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩

مصطلحات موضوعية: Receptor Protein-Tyrosine Kinases, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, General Medicine, Biochemistry, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.CAN] Life Sciences [q-bio]/Cancer, Mutation, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Colorectal Neoplasms, Cell Adhesion Molecules, Wnt Signaling Pathway, beta Catenin, Cell Proliferation

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c580cd45ec237bff1974a96c91e97eTest
https://pubmed.ncbi.nlm.nih.gov/35483008Test

المؤلفون: Kendall Carrasco, Camille Montersino, Carine Derviaux, Magali Saez-Ayala, Laurent Hoffer, Audrey Restouin, Rémy Castellano, Justine Casassa, Philippe Roche, Eddy Pasquier, Sébastien Combes, Xavier Morelli, Yves Collette, Stéphane Betzi

المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Betzi, Stéphane

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩

مصطلحات موضوعية: potentiation, diversity-oriented library, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], bone-marrow-derived stromal cell conditioned medium, Nuclear Proteins, Bromodomain, Cell Cycle Proteins, [SDV.CAN]Life Sciences [q-bio]/Cancer, focused library, drug discovery, Small Molecule Libraries, protein-protein interaction, BDII selective inhibitor, Structure-Activity Relationship, modulation, Protein Domains, [SDV.CAN] Life Sciences [q-bio]/Cancer, hit-to-lead, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Medicine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, optimization, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0378e958b388b76b3d8b2be970b66b5eTest
https://hal.science/hal-03624836Test

المؤلفون: Philippe Roche, Xavier Morelli, Manon Garcia, Fatiha Benmansour, Raphael Leblanc, Laurent Hoffer, Antonio Luis Egea-Jimenez, Carine Derviaux, Mikael Feracci, Pascale Zimmermann, Karine Barral

المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-18-CE13-0017,SynTEV,Rôle des réseaux tétraspanines-syndécanes-PDZ dans l'hétérogénéité moléculaire et fonctionelle des vésicules extracellulaires(2018), ROCHE, Philippe, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, APPEL À PROJETS GÉNÉRIQUE 2018 - Rôle des réseaux tétraspanines-syndécanes-PDZ dans l'hétérogénéité moléculaire et fonctionelle des vésicules extracellulaires - - SynTEV2018 - ANR-18-CE13-0017 - AAPG2018 - VALID

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2021, 223, pp.113601. ⟨10.1016/j.ejmech.2021.113601⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, 223, pp.113601. ⟨10.1016/j.ejmech.2021.113601⟩

مصطلحات موضوعية: Cancer therapy, Syntenins, PDZ Domains, Peptide, Exosomes, 01 natural sciences, Small molecule PPI inhibitor, Drug Discovery, Benzene Derivatives, [CHIM.CHEM] Chemical Sciences/Cheminformatics, Amino Acids, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS, media_common, chemistry.chemical_classification, 0303 health sciences, Molecular Structure, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, General Medicine, Small molecule, 3. Good health, Cell biology, Molecular Docking Simulation, MCF-7 Cells, Fragment-based drug design, [CHIM.CHEM]Chemical Sciences/Cheminformatics, Protein Binding, Drug, Syndecans, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], media_common.quotation_subject, PDZ domain, Antineoplastic Agents, [SDV.CAN]Life Sciences [q-bio]/Cancer, Exosome, Small Molecule Libraries, 03 medical and health sciences, Structure-Activity Relationship, Downregulation and upregulation, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, Binding site, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Syntenin-syndecan interaction inhibitors, 030304 developmental biology, Pharmacology, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Docking (molecular), Drug Design, Exosomes biogenesis

وصف الملف: Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43013ddd9d4672c25efc8990391d57d8Test
https://hal.science/hal-03379016/file/EJMCh_Barral_2021_27052021.pdfTest

المؤلفون: Christophe Muller, Stephane Betzi, Laetitia Ganier, Carine Derviaux, Xavier Morelli, Laurent Hoffer, Philippe Roche, Jean-Paul Borg

مصطلحات موضوعية: Colorectal cancer, Cell growth, Kinase, Chemistry, Catenin, medicine, Cancer research, Wnt signaling pathway, PTK7, medicine.disease, Beta (finance), Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::021e982fb79966354fefd7988d69fdeaTest
https://doi.org/10.1101/2021.10.15.464507Test

المؤلفون: Laurent, Hoffer, Philippe, Roche, Xavier, Morelli

المصدر: Methods in molecular biology (Clifton, N.J.). 2256

مصطلحات موضوعية: Small Molecule Libraries, Drug Design, Drug Discovery, Animals, Humans, PDZ Domains, Proteins, Protein Interaction Domains and Motifs, Peptidomimetics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::c88ac5e77ea498a65b096a9ade5e56f6Test
https://pubmed.ncbi.nlm.nih.gov/34014528Test