Ocular involvement in STEC-associated hemolytic uremic syndrome
| العنوان: | Ocular involvement in STEC-associated hemolytic uremic syndrome |
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| المؤلفون: | Ana P, Spizzirri, Carlos J, Cobeñas, Laura F, Alconcher, Néstor, Murray, Claudia, Zarate, Laura, Curutchet, Emanuel, De Rose, María José, Gogorza, Lucas, Lucarelli, Javier, Ruscasso, Laura, Lombardi, Priscila, Pereyra, Javier, Zalba, Paula, Risso, Angela, Suarez |
| المصدر: | Pediatric Nephrology. 37:2699-2703 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Shiga-Toxigenic Escherichia coli, Central Nervous System Diseases, Renal Dialysis, Thrombotic Microangiopathies, Nephrology, Child, Preschool, Hemolytic-Uremic Syndrome, Pediatrics, Perinatology and Child Health, Humans, Female, Prospective Studies |
| الوصف: | Hemolytic uremic syndrome (HUS) is a systemic thrombotic microangiopathy characterized by hemolytic anemia, thrombocytopenia, and variable kidney involvement. Extrarenal thrombotic microangiopathy occurs in central nervous system (CNS), colon, and other organ systems, but ocular involvement is rarely recognized. This study aimed to analyze frequency and severity of ocular involvement in STEC-HUS, and the relationship between ocular involvement and disease severity, with emphasis on CNS, kidney, and colonic disease.Prospective, longitudinal, observational study.STEC-HUS patients September 2014-January 2019. Funduscopic examination (FE) was performed within 48 h of admission. We evaluated severity of CNS disease, kidney involvement, and presence of hemorrhagic colitis (HC).Ninety-nine patients were included (female 52), mean age 39.4 months (DE: 29.8; range 9-132). Thirteen patients (13.1%) had abnormal FE, 10 showing variable degrees of hemorrhagic exudates and 2 with typical Purtscher-like retinopathy. Other findings included tortuous vascularity, cotton wool spots, and transient retinal edema. CNS involvement was present in 16/99 patients, severe in 12 (75%). Abnormal FE occurred in 5/12 (31%) patients with severe CNS involvement vs. 8/87 (9.2%) with mild, moderate, or no CNS disease (p = 0.0191). Abnormal FE was present in 2/33 (6%) patients without dialysis vs. 11/66 (16.6%) requiring dialysis (p = 0.20). Finally, there were FE abnormalities in 6/20 patients with HC vs. 7/79 without HC (p = 0.012).FE abnormalities were present in 13% of HUS patients. Abnormal FE significantly associated with more severe disease, including severe CNS involvement and HC. We suggest FE should be performed in severe HUS, especially in cases with severe CNS disease. A higher resolution version of the Graphical abstract is available as Supplementary information. |
| تدمد: | 1432-198X 0931-041X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b76e646b5891228a1885e74b1ed6ceaTest https://doi.org/10.1007/s00467-022-05587-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4b76e646b5891228a1885e74b1ed6cea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432198X 0931041X |
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