المؤلفون: Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Mei Kwan, Jose Beltran, Afshin Ghavami, Srinivasa Subramaniam, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Larry Park, Ignacio Muñoz-Sanjuán, Deanna M Marchionini

المصدر: PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/5d08393a3e9247bea54802339f2736c8Test

المؤلفون: Liliana Menalled, Bassem F. El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J. Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X. William Yang, Marcy MacDonald, A. Jennifer Morton, Gill Bates, Janet Leeds, Larry Park, David Howland, Ethan Signer, Allan Tobin, Daniela Brunner

المصدر: Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996109001077Test; https://doaj.org/toc/1095-953XTest

الوصول الحر: https://doaj.org/article/af9fd89edd134459a71f0f5fc6d5f00aTest

المؤلفون: Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Igor Filippov, Sam Miller, Mei Kwan, Michael Olsen, Jose Beltran, Justin Torello, Jon Fitzpatrick, Richard Mushlin, Kimberly Cox, Kristi McConnell, Matthew Mazzella, Dansha He, Georgina F Osborne, Rand Al-Nackkash, Gill P Bates, Pasi Tuunanen, Kimmo Lehtimaki, Dani Brunner, Afshin Ghavami, Sylvie Ramboz, Larry Park, Douglas Macdonald, Ignacio Munoz-Sanjuan, David Howland

المصدر: PLoS ONE, Vol 9, Iss 6, p e99520 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4067284?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/32ac64f0a9ee4c26afbcfdfbe927af3cTest

المؤلفون: Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates

المصدر: PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3841096?pdf=renderTest; https://doaj.org/toc/1544-9173Test; https://doaj.org/toc/1545-7885Test

الوصول الحر: https://doaj.org/article/36f0a78b62114715a37984063f3cb2d9Test

المؤلفون: Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner

المصدر: PLoS ONE, Vol 5, Iss 3, p e9793 (2010)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC2842438?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/4fa4ff5e21dd404d8e4ec783503ea5d3Test

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

العلاقة: https://figshare.com/articles/journal_contribution/S1_File_-/16812172Test

الإتاحة: https://doi.org/10.1371/journal.pone.0258486.s005Test

المؤلفون: Georg Kempf, Ignacio Munoz-Sanjuan, Alexandros Patsilinakos, Matteo Andreini, Stefania Colarusso, Vincenzo Summa, Jesus Maria Ontoria Ontoria, Federica Ferrigno, Paola Fezzardi, Steven J. Harper, Leticia Toledo Sherman, Stefan Steinbacher, Ilaria Biancofiore, Esther Torrente, Martin Augustin, Elisabetta Bianchi, Larry Park, Alberto Bresciani, Robert Pacifici, Celia Dominguez

المساهمون: Ontoria, J. M., Biancofiore, I., Fezzardi, P., Ferrigno, F., Torrente, E., Colarusso, S., Bianchi, E., Andreini, M., Patsilinakos, A., Kempf, G., Augustin, M., Steinbacher, S., Summa, V., Pacifici, R., Munoz-Sanjuan, I., Park, L., Bresciani, A., Dominguez, C., Sherman, L. T., Harper, S.

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Tetrahydroisoquinoline, Organic Chemistry, Huntington's disease, Peptide, respiratory system, digestive system, environment and public health, Biochemistry, KEAP1, Small molecule, Keap1 nrf2, NRF2, Protein–protein interaction, Negative regulator, protein-protein interaction, chemistry.chemical_compound, THIQ, Drug Discovery, Biophysics, medicine, tetrahydroisoquinoline, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697530dc3724a96d48064e27557ca038Test
https://doi.org/10.1021/acsmedchemlett.9b00594Test

المؤلفون: Rob Gill, Jim Rosinski, Viktoria Andreeva, Richard A. Blevins, Jian Chen, Anastasia Shneyderman, Larry Park, Jeff Aaronson, Vahri Beaumont, Kabenla Armah, Irina Murasheva, Giovanni Coppola, Thomas F. Vogt, Ignacio Munoz-Sanjuan

المصدر: Journal of Huntington's disease. 10(3)

مصطلحات موضوعية: World Wide Web, Cellular and Molecular Neuroscience, Data portal, Huntington Disease, Huntington's disease, Computer science, Research community, medicine, High definition, Humans, Neurology (clinical), medicine.disease, Intervention studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b47702138e6b88f10448f37db48312Test
https://pubmed.ncbi.nlm.nih.gov/34397420Test

المؤلفون: Jose Beltran, Teija Parkkari, Sanna Gustafsson, Neelam Shahani, Afshin Ghavami, Larry Park, Taneli Heikkinen, Mei Kwan, Deanna Marchionini, Srinivasa Subramaniam, Juha Kuosmanen, Uri Nimrod Ramírez-Jarquín, Timo Bragge, Ignacio Munoz-Sanjuan

المصدر: PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)

مصطلحات موضوعية: Male, Huntingtin, Mutant, Social Sciences, Striatum, medicine.disease_cause, Biochemistry, Diagnostic Radiology, Mice, Medical Conditions, Medicine and Health Sciences, Psychology, Mice, Knockout, Mutation, Huntingtin Protein, Multidisciplinary, Cell Death, Animal Behavior, TOR Serine-Threonine Kinases, Radiology and Imaging, Brain, Neurodegenerative Diseases, Animal Models, Polyglutamine tract, Magnetic Resonance Imaging, SUMOylation, Cell biology, Biomechanical Phenomena, Huntington Disease, Phenotype, Experimental Organism Systems, Neurology, Cell Processes, Genetic Diseases, Medicine, Female, Post-translational modification, Anatomy, Signal Transduction, Research Article, Dopamine and cAMP-Regulated Phosphoprotein 32, Imaging Techniques, Science, Autophagic Cell Death, Mouse Models, Biology, Research and Analysis Methods, Model Organisms, Huntington's disease, GTP-Binding Proteins, Diagnostic Medicine, medicine, Genetics, Animals, PI3K/AKT/mTOR pathway, Clinical Genetics, Behavior, Autophagy, Body Weight, Autosomal Dominant Diseases, Biology and Life Sciences, Proteins, Cell Biology, medicine.disease, Mice, Inbred C57BL, Neostriatum, Disease Models, Animal, nervous system, Animal Studies, Zoology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6878ef4acd983462325493f313aadebcTest
https://pubmed.ncbi.nlm.nih.gov/34648564Test

المؤلفون: Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao

المصدر: Nature Medicine. 25:1131-1142

مصطلحات موضوعية: 0301 basic medicine, Zinc finger, congenital, hereditary, and neonatal diseases and abnormalities, Mutant, General Medicine, Biology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, nervous system diseases, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Huntington's disease, Transcription (biology), 030220 oncology & carcinogenesis, mental disorders, medicine, Gene silencing, Allele, Gene, Transcription factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6Test
https://doi.org/10.1038/s41591-019-0478-3Test