دورية أكاديمية
Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman
| العنوان: | Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman |
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| المؤلفون: | Nalova Ikome, Hermia, Tamfu, Alfred, Abdou, Jean, Fouotsa, Hugues, Nangmo, Pamela, Castro, Fidèle, Lah, Weyepe, Tchinda, Alembert, Ceylan, Ozgur, Frederich, Michel, Nkengfack, Augustin |
| المصدر: | Applied Biochemistry and Biotechnology, 195 (10), 6113-6131 (2023-02-22) |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Zanthoxylum gilletii, Secondary metabolites, Antimicrobial activity, Antibiofilm, Anti-quorum sensing, Molecular Biology, Applied Microbiology and Biotechnology, Biochemistry, General Medicine, Bioengineering, Biotechnology, Human health sciences, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie |
| الوصف: | Microbial resistance is facilitated by biofilm formation and quorum-sensing mediated processes. In this work, the stem bark (ZM) and fruit extracts (ZMFT) of Zanthoxylum gilletii were subjected to column chromatography and afforded lupeol (1), 2,3-epoxy-6,7-methylenedioxyconiferyl alcohol (3), nitidine chloride (4), nitidine (7), sucrose (6) and sitosterolβ-D-glucopyranoside (2). The compounds were characterized using MS and NMR spectral data. The samples were evaluated for antimicrobial, antibiofilm and anti-quorum sensing activities. Highest antimicrobial activity was exhibited by compounds 3, 4 and 7 against Staphylococcus aureus (MIC 200 µg/mL), compounds 3 and 4 against Escherichia coli (MIC = 100 µg/mL) and compounds 4 and 7 against Candida albicans (MIC = 50 µg/mL). At MIC and sub-MIC concentrations, all samples inhibited biofilm formation by pathogens and violacein production in C. violaceum CV12472 except compound 6. Good disruption of QS-sensing in C. violaceum revealed by inhibition zone diameters were exhibited by compounds 3 (11.5 ± 0.5 mm), 4 (12.5 ± 1.5 mm), 5 (15.0 ± 0.8 mm), 7 (12.0 ± 1.5 mm) as well as the crude extracts from stem barks (16.5 ± 1.2 mm) and seeds (13.0 ± 1.4 mm). The profound inhibition of quorum sensing mediated processes in test pathogens by compounds 3, 4, 5 and 7 suggests the methylenedioxy-group that these compounds possess as the possible pharmacophore. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | https://link.springer.com/content/pdf/10.1007/s12010-023-04380-6.pdfTest; urn:issn:0273-2289; urn:issn:1559-0291 |
| DOI: | 10.1007/s12010-023-04380-6 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/313729Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.313729 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/s12010-023-04380-6 |
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