دورية أكاديمية
Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.
| العنوان: | Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. |
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| المساهمون: | JH Choi, MG Lee, J-Y Cho, J-E Lee, KH Kim, K Park, Kim, Kyung Hwan, Park, Kyung Soo, Lee, Min Goo |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Administration, Oral, Area Under Curve, Asian Continental Ancestry Group/genetics, Fluorobenzenes/administration & dosage, Fluorobenzenes/blood, Fluorobenzenes/pharmacokinetics, Gene Frequency, Genotype, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage, Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood, Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics, Korea, Lactones/administration & dosage, Lactones/blood, Lactones/pharmacokinetics, Organic Anion Transporters/genetics, Organic Anion Transporters/metabolism, Phenotype, Polymorphism, Genetic, Pyrimidines/administration & dosage, Pyrimidines/blood, Pyrimidines/pharmacokinetics, Rosuvastatin Calcium, Solute Carrier Organic Anion Transporter Family Member 1b1, Sulfonamides/administration & dosage, Sulfonamides/blood, Sulfonamides/pharmacokinetics |
| الوصف: | This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 251~257 |
| اللغة: | unknown |
| تدمد: | 0009-9236 1532-6535 |
| العلاقة: | CLINICAL PHARMACOLOGY & THERAPEUTICS; J00608; OAK-2008-00013; https://ir.ymlib.yonsei.ac.kr/handle/22282913/106133Test; http://www.nature.com/clpt/journal/v83/n2/full/6100267a.htmlTest; T200800010; CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol.83(2) : 251-257, 2008 |
| DOI: | 10.1038/sj.clpt.6100267 |
| الإتاحة: | https://doi.org/10.1038/sj.clpt.6100267Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/106133Test http://www.nature.com/clpt/journal/v83/n2/full/6100267a.htmlTest |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.6E181ABA |
| قاعدة البيانات: | BASE |
| تدمد: | 00099236 15326535 |
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| DOI: | 10.1038/sj.clpt.6100267 |