التفاصيل البيبلوغرافية
| العنوان: |
Effects of pioglitazone on lipid and lipoprotein profiles in patients with type 2 diabetes and dyslipidaemia after treatment conversion from rosiglitazone while continuing stable statin therapy |
| المؤلفون: |
Berhanu, Paulos, Kipnes, Mark S, Khan, Mehmood A, Perez, Alfonso T, Kupfer, Stuart F, Spanheimer, Robert G, Demissie, Seleshi, Fleck, Penny R |
| المصدر: |
Diabetes and Vascular Disease Research ; volume 3, issue 1, page 39-44 ; ISSN 1479-1641 1752-8984 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2006 |
| مصطلحات موضوعية: |
Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| الوصف: |
4 The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking stable dosages of rosiglitazone and statins for > 90 days. At baseline, patients discontinued rosiglitazone and started pioglitazone 30 mg/day, but continued statins and other lipid-altering therapies. The primary end point was change from baseline in fasting triglyceride levels. At 17 weeks after treatment conversion, patients had significant reductions in triglycerides (-15.2%), total cholesterol (-9.0%), and low-density lipoprotein (LDL) particle concentration (-189 nmol/L), and increases in LDL cholesterol (+2.2%), high-density lipoprotein (HDL) cholesterol (+1.8%), and LDL particle diameter (+0.23 nm). In conclusion, after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin therapy, patients with type 2 diabetes had marked improvements in lipid profiles along with stable glycaemic control. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.3132/dvdr.2006.005 |
| الإتاحة: |
https://doi.org/10.3132/dvdr.2006.005Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.860B4B88 |
| قاعدة البيانات: |
BASE |
