Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells
| العنوان: | Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells |
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| المؤلفون: | Nathan H. Chen, Krystelle Davey, Cheryl-lynn Y. Ong, Jonathan O'sullivan, Alastair G. McEwan, Ines Ibranovic, Jennifer L. Edwards |
| المصدر: | J Infect Dis |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Iron, Metabolite, 030106 microbiology, Flavoprotein, Dehydrogenase, Cervix Uteri, Biology, medicine.disease_cause, Microbiology, Gonorrhea, Major Articles and Brief Reports, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Lactate dehydrogenase, medicine, Humans, Immunology and Allergy, L lactate, Microbial Viability, L-Lactate Dehydrogenase, Host (biology), Epithelial Cells, Gene Expression Regulation, Bacterial, Neisseria gonorrhoeae, In vitro, 030104 developmental biology, Infectious Diseases, chemistry, biology.protein, RNA, Viral, Female, Gene Deletion |
| الوصف: | L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4302016aa3869703411316e5da3b22Test https://doi.org/10.1093/infdis/jiz468Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0c4302016aa3869703411316e5da3b22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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