-
1
المؤلفون: Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3037-3042
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Humans, Potency, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, Chemistry, Hydantoins, Organic Chemistry, Haplorhini, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, Area Under Curve, Molecular Medicine, Tumor necrosis factor alpha, Half-Life, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ae78bb60384e5c554a062fa84b16eTest
https://doi.org/10.1016/j.bmcl.2017.05.062Test -
2
المؤلفون: Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3172-3176
مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Oral administration, Amide, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Amides, Rats, Enzyme Activation, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe3fdf02a5dba0580b311b55f7fe2Test
https://doi.org/10.1016/j.bmcl.2011.01.002Test -
3
المؤلفون: Liping Yang, Shelby Umland, Peter Orth, Daniel Lundell, Luke Firmansjah, Feltz Robert, Chaoyang Dai, Joseph A. Kozlowski, Wensheng Yu, Janeta Popovici-Muller, Seong Heon Kim, Vincent S. Madison, John J. Piwinski, De-Yi Yang, M. Arshad Siddiqui, Ling Tong, Xiaoda Niu, Brian J. Lavey, Guowei Zhou, Banderpalle B. Shankar, Razia Rizvi, Kristin E. Rosner, Neng-Yang Shih, Aneta Kosinski, Hong Bian, Dansu Li, Vinay Girijavallabhan, Lei Chen, Himanshu Shah, Zhuyan Guo, Jing Sun, Wong Michael K C
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7283-7287
مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Arthritis, Rheumatoid, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, biology, Acetylene, Organic Chemistry, Biological activity, Haplorhini, In vitro, Rats, ADAM Proteins, Cytokine, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Tumor necrosis factor alpha
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13e3eb17b7abab77da7bd68ad794d7Test
https://doi.org/10.1016/j.bmcl.2010.10.081Test -
4
المؤلفون: Bandarpalle B. Shankar, Ling Tong, Himanshu Shah, Wensheng Yu, Jing Sun, De-Yi Yang, Guowei Zhou, Lei Chen, Feltz Robert, Kristin E. Rosner, Xiaoda Niu, Neng-Yang Shih, Shelby Umland, Zhuyan Guo, John J. Piwinski, Seong Heon Kim, Dansu Li, Razia Rizvi, Peter Orth, Aneta Kosinski, Wong Michael K C, Joseph A. Kozlowski, Daniel Lundell, M. Arshad Siddiqui, Brian J. Lavey
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5286-5289
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Hydrolase, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, Active site, Biological activity, Rats, ADAM Proteins, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0544f42865077bfcb9c1747073ba2311Test
https://doi.org/10.1016/j.bmcl.2010.06.134Test -
5
المؤلفون: Jing Sun, Corey O. Strickland, John P. Caldwell, Kristin E. Rosner, Pauline C. Ting, Bandarpalle B. Shankar, Shiying Chen, David B. Belanger, Gerald W. Shipps, Vinay Girijavallabhan, Guowei Zhou, Brian J. Lavey, Dansu Li, Razia Rizvi, Peter Orth, Neng-Yang Shih, M. Arshad Siddiqui, Zhaoning Zhu, Wensheng Yu, Zhuyan Guo, Zhidan Liu, Maria David, John J. Piwinski, Daniel Lundell, Henry M. Vaccaro, Joe F. Lee, Jim Spitler, Vincent S. Madison, Xiaoda Niu, Chaoyang Dai, Mckittrick Brian A, Joseph A. Kozlowski, Janeta Popovici-Muller, Rob Mazzola
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4812-4815
مصطلحات موضوعية: Molecular model, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Computer Simulation, Protease Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, In vitro, Rats, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b8670bf1029b4ff13b82406eff8483Test
https://doi.org/10.1016/j.bmcl.2010.06.104Test -
6
المؤلفون: Gerald W. Shipps, Alan B. Cooper, Yongqi Deng, Michael B. Cable, Meredith A. Brown, Janeta Popovici-Muller, Jose S. Duca, Kristin E. Rosner, M. Arshad Siddiqui, Viyyoor M. Girijavallabhan, Tong Wang, Patrick J. Curran
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6331-6336
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Biochemistry, Small Molecule Libraries, Inhibitory Concentration 50, chemistry.chemical_compound, Drug Discovery, Enzyme Inhibitors, Molecular Biology, Polymerase, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, DNA-Directed RNA Polymerases, RNA-Dependent RNA Polymerase, Hepatitis C, Molecular Weight, Pyrimidines, biology.protein, Pyrazoles, RNA, Viral, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c960c41c52edef05255149b4761d235Test
https://doi.org/10.1016/j.bmcl.2009.09.087Test -
7
المؤلفون: D. Allen Annis, Jean Paul A. Orminati, G. R.A. Thaddupathy, Patrick J. Curran, Krishna Kalghatgi, Edward A. Wintner, Gerald W. Shipps, Huw M. Nash, William H. Lee, Kristin E. Rosner, Andrew N. Tyler, Carston R. Wagner, John Athanasopoulos, Lev Vilenchik, Jason S. Felsch
المصدر: International Journal of Mass Spectrometry. 238:77-83
مصطلحات موضوعية: biology, Ligand, Chemistry, Drug discovery, Antagonist, Biological activity, Condensed Matter Physics, Mass spectrometry, medicine.disease_cause, Small molecule, Combinatorial chemistry, Dihydrofolate reductase, biology.protein, medicine, Physical and Theoretical Chemistry, Instrumentation, Escherichia coli, Spectroscopy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ae966614540c07151bcb313c4614775aTest
https://doi.org/10.1016/j.ijms.2003.11.022Test -
8
المؤلفون: Kristin E. Rosner, Ernesto Menta, Anna L. Helgason, Miles P. Hacker, Martin J. Maresch, Silvano Spinelli, A. Paul Krapcho, Ambrogio Oliva
المصدر: Journal of Heterocyclic Chemistry. 30:1597-1606
مصطلحات موضوعية: chemistry.chemical_compound, Quinoxaline, chemistry, Hydrochloride, Stereochemistry, Organic Chemistry, Trifluoroacetic acid, Quinazoline, Ethylenediamine, Electrophilic aromatic substitution, Phthalazine, Quinone
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2dfa0091161bfe15e9dfe34073de5110Test
https://doi.org/10.1002/jhet.5570300624Test -
9
المؤلفون: Feltz Robert, Kristin E. Rosner, De-Yi Yang, Janeta Popovici-Muller, Daniel Lundell, M. Arshad Siddiqui, Peter Orth, John J. Piwinski, Bandarpalle B. Shankar, Shelby Umland, Guowei Zhou, Zhuyan Guo, Ling Tong, Vincent S. Madison, Razia Rizvi, Xiaoda Niu, Neng-Yang Shih, Chaoyang Dai, Joseph A. Kozlowski, Wong Michael K C, Seong Heon Kim, Dansu Li, Jing Sun, Vinay Girijavallabhan, Lei Chen, Brian J. Lavey, Wensheng Yu
المصدر: Bioorganicmedicinal chemistry letters. 20(6)
مصطلحات موضوعية: Models, Molecular, Denticity, Zinc binding, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Hydantoin, Zinc, ADAM17 Protein, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, X-Ray Diffraction, Drug Discovery, Structure–activity relationship, Moiety, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Ligand, Hydantoins, Organic Chemistry, Hydrogen Bonding, ADAM Proteins, Enzyme, chemistry, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f39d5f4051d8a87a9707d21fbe52849Test
https://pubmed.ncbi.nlm.nih.gov/20172725Test -
10
المؤلفون: Piwinski John J, Corey O. Strickland, Jing Sun, Patrick J. Curran, Vinay Girijavallabhan, Zhuyan Guo, Li Wang, Shih Neng-Yang, Liwu Hong, Yongqi Deng, Pauline C. Ting, Daniel Lundell, Guowei Zhou, Gerald W. Shipps, Chan Tin Yau, Wensheng Yu, Zhidan Liu, Joe F. Lee, M. Arshad Siddiqui, Janeta Popovici-Muller, Xiaoda Niu, Brian J. Lavey, Vincent Madison, Tong Wang, Chaoyang Dai, Joseph A. Kozlowski, Mckittrick Brian A, Kristin E. Rosner, David B. Belanger, Vaccaro Henry A, Dansu Li, Peter Orth
المصدر: Bioorganicmedicinal chemistry letters. 20(3)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Tartrate, Matrix metalloproteinase, ADAM17 Protein, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Hydrolase, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Protease Inhibitors, Molecular Biology, Tartrates, chemistry.chemical_classification, Binding Sites, biology, Tumor Necrosis Factor-alpha, Organic Chemistry, Active site, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Tartaric acid, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389e5b82ce82b8555a1543681cf0b86dTest
https://pubmed.ncbi.nlm.nih.gov/20022498Test